Effects of varying gene targeting parameters on processing of recombination intermediates by ERCC1–XPF

Autor: Jennifer J. Rahn, Rodney S. Nairn, Megan P. Lowery, Gerald M. Adair, Brian Rowley, Luis Della Coletta, Tiffany Limanni

Publikováno v: DNA Repair. 10:188-198

The ERCC1-XPF structure-specific endonuclease is necessary for correct processing of homologous recombination intermediates requiring the removal of end-blocking nonhomologies. We previously showed that targeting the endogenous CHO APRT locus with pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa955935a7c36192e0e55aca34abf0f
https://doi.org/10.1016/j.dnarep.2010.10.011

Genetic and environmental melanoma models in fish

Autor: David L. Mitchell, E. Elizabeth Patton, Rodney S. Nairn

Publikováno v: Pigment Cell & Melanoma Research; Vol 23
Pigment Cell & Melanoma Research
Patton, E E, Mitchell, D L & Nairn, R S 2010, ' Genetic and environmental melanoma models in fish ', Pigment Cell and Melanoma Research, vol. 23, no. 3, pp. 314-337 . https://doi.org/10.1111/j.1755-148X.2010.00693.x

P>Experimental animal models are extremely valuable for the study of human diseases, especially those with underlying genetic components. The exploitation of various animal models, from fruitflies to mice, has led to major advances in our understandi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01de163d2ade20663d17e665690ce76

Targeted gene conversion induced by triplex-directed psoralen interstrand crosslinks in mammalian cells

Autor: Yaobin Liu, Rodney S. Nairn, Karen M. Vasquez

Publikováno v: Nucleic Acids Research

Correction of a defective gene is a promising approach for both basic research and clinical gene therapy. However, the absence of site-specific targeting and the low efficiency of homologous recombination in human cells present barriers to successful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359eefb018c93d34ec5b28fe7b9fe914
https://doi.org/10.1093/nar/gkp678

Characterization of CHO XPF mutant UV41: Influence of XPF heterozygosity on double-strand break-induced intrachromosomal recombination

Autor: Gerald M. Adair, Leisa L. Talbert, Angela Bolt, David Trono, Megan G. Lowery, Rodney S. Nairn, Luis Della Coletta

Publikováno v: DNA Repair. 7:1319-1329

The UV hypersensitive CHO cell mutant UV41 is the archetypal XPF mammalian cell mutant, and was essential for cloning the human nucleotide excision repair (NER) gene XPF by DNA transfection and rescue. The ERCC1 and XPF genes encode proteins that for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efacb304b53d2d9526ee3cc80487c82
https://doi.org/10.1016/j.dnarep.2008.04.012

Regulation of CDKN2A/B and Retinoblastoma genes in Xiphophorus melanoma

Autor: Rachel Fraijo, Andrew P. Butler, Rebecca Beard, Luis Della Coletta, Steven Kazianis, Rodney S. Nairn, David Trono

Publikováno v: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 145:145-155

Xiphophorus interspecies hybrids provide several well-characterized genetic models of melanoma susceptibility. The Xiphophorus CDKN2A/B gene, homologous to mammalian CDKN2A/B cyclin-dependent kinase inhibitors (p16 and p15), is a candidate tumor susc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cbe1ab412e73359b946a086d7de6f7
https://doi.org/10.1016/j.cbpc.2006.07.013