Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Rodney Rothstein"'
Autor:
Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-3 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/43f2f351f5f845a58e903c76ecfc62de
Autor:
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova
Publikováno v:
Microbial Cell, Vol 6, Iss 1, Pp 1-64 (2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily
Externí odkaz:
https://doaj.org/article/9deb4e4edc524ec78e599b9f614eaef3
Autor:
Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK kinases downstream of KRAS have had limited success in clinical trials. Understandin
Externí odkaz:
https://doaj.org/article/98f6a24767ca469eb06b9f4fac8d24c6
Autor:
Benoit Palancade, Rodney Rothstein
Publikováno v:
Cells, Vol 10, Iss 6, p 1433 (2021)
RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity. Strikingly, different enzymatic activities classically involved in genome m
Externí odkaz:
https://doaj.org/article/3de7486fa0ef41499d5c1b9402fe30d8
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1681-1692.e4 (2018)
Summary: The yeast Mre11-Rad50-Xrs2 (MRX) complex has structural, signaling, and catalytic functions in the response to DNA damage. Xrs2, the eukaryotic-specific component of the complex, is required for nuclear import of Mre11 and Rad50 and to recru
Externí odkaz:
https://doaj.org/article/a2b34a34e09f4a1789a867669df12a7b
Autor:
Paula M van Mourik, Jannie de Jong, Danielle Agpalo, Clémence Claussin, Rodney Rothstein, Michael Chang
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151314 (2016)
In cells lacking telomerase, telomeres shorten progressively during each cell division due to incomplete end-replication. When the telomeres become very short, cells enter a state that blocks cell division, termed senescence. A subset of these cells
Externí odkaz:
https://doaj.org/article/124efe403dc84ca787d5ea96bb891cde
Autor:
Rebecca C Burgess, Marek Sebesta, Alexandra Sisakova, Victoria P Marini, Michael Lisby, Jiri Damborsky, Hannah Klein, Rodney Rothstein, Lumir Krejci
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82630 (2013)
Rad54 is an ATP-driven translocase involved in the genome maintenance pathway of homologous recombination (HR). Although its activity has been implicated in several steps of HR, its exact role(s) at each step are still not fully understood. We have i
Externí odkaz:
https://doaj.org/article/64188a082a04436cb02cf3915790e109
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003237 (2013)
DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid as the preferential repair template is critical for genome integrity, but the mechanisms that guarantee this choice are unkno
Externí odkaz:
https://doaj.org/article/7d122e731fbc4d86a06d761d751d0e64
Autor:
Heiko Poschke, Martina Dees, Michael Chang, Sandeep Amberkar, Lars Kaderali, Rodney Rothstein, Brian Luke
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002960 (2012)
Using a genome-wide screening approach, we have established the genetic requirements for proper telomere structure in Saccharomyces cerevisiae. We uncovered 112 genes, many of which have not previously been implicated in telomere function, that are r
Externí odkaz:
https://doaj.org/article/0d1fb59b9be34b4e82f6c78c99c274ed
Publikováno v:
PLoS Genetics, Vol 3, Iss 12, p e228 (2007)
To investigate the DNA damage response, we undertook a genome-wide study in Saccharomyces cerevisiae and identified 86 gene deletions that lead to increased levels of spontaneous Rad52 foci in proliferating diploid cells. More than half of the genes
Externí odkaz:
https://doaj.org/article/b78df888efe44212a47bdcfa43191e99