Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rodney M. Hewick"'
Publikováno v:
Advances in protein chemistry. 65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da1dfbfaeaee238dedd457cee1065036
https://pubmed.ncbi.nlm.nih.gov/12964374
https://pubmed.ncbi.nlm.nih.gov/12964374
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 17(6)
Myostatin, a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene (FLRG). He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27c2f4565f25b8ae453712b960c21d
https://pubmed.ncbi.nlm.nih.gov/12595574
https://pubmed.ncbi.nlm.nih.gov/12595574
Publisher Summary This chapter describes proteomics technology and discusses the technical problems associated with proteome analysis along with ways to overcome the respective problems. It includes a representative selection of examples of the appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2ab7c1364d5c2383d3c9151bfce615
https://doi.org/10.1016/s0065-3233(03)01024-6
https://doi.org/10.1016/s0065-3233(03)01024-6
Publikováno v:
Analytical chemistry. 74(19)
Quantitative mass spectrometry using stable isotope-labeled tagging reagents such as isotope-coded affinity tags has emerged as a powerful tool for identification and relative quantitation of proteins in current proteomic studies. Here we describe an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e07deb42da91f31f2ae3713b28c80bc
https://pubmed.ncbi.nlm.nih.gov/12380819
https://pubmed.ncbi.nlm.nih.gov/12380819
Autor:
Jennifer J. Hill, Adele A. Pearson, Rodney M. Hewick, Yongchang Qiu, Monique V. Davies, Neil M. Wolfman, Jack H. Wang
Publikováno v:
The Journal of biological chemistry. 277(43)
Myostatin, also known as growth and differentiation factor 8, is a member of the transforming growth factor β superfamily that negatively regulates skeletal muscle mass (1). Recent experiments have shown that myostatin activity is detected in serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93ef0f54c4ec57e6b23c8b65f443519
https://pubmed.ncbi.nlm.nih.gov/12194980
https://pubmed.ncbi.nlm.nih.gov/12194980
Autor:
Rodney M. Hewick, Jack H. Wang
Publikováno v:
Drug discovery today. 4(3)
The promise of genomics has dramatically altered the way drug discovery is now viewed. Overshadowed by the exuberance for genomics are the observations that most disease processes and treatments are manifest at the protein level and that there may no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8ed20198a9ae5e002bc53164570c60
https://pubmed.ncbi.nlm.nih.gov/10322265
https://pubmed.ncbi.nlm.nih.gov/10322265
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 14(6)
Bone morphogenetic proteins have been shown to increase matrix synthesis by articular chondrocytes in short-term cultures. Members of this family of proteins have also been shown to induce endochondral ossification in vivo. The present study was perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcc3fc5e30ecd8eabcc51876cfb7850
https://pubmed.ncbi.nlm.nih.gov/8982137
https://pubmed.ncbi.nlm.nih.gov/8982137
Autor:
Robin C. Taylor, Vicki Rosen, Rodney M. Hewick, Elizabeth A. Wang, Anthony J. Celeste, James A. Iannazzi, John M. Wozney
Characterization of the polypeptides present in bone-inductive protein extracts from bovine bone has led to the cloning of seven regulatory molecules, six of which are distantly related to transforming growth factor beta. The three human bone morphog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3470fda7bf90f2913def55f6449787a6
https://europepmc.org/articles/PMC55270/
https://europepmc.org/articles/PMC55270/
Autor:
K M Kerns, T Harada, Paul Cordes, Vicki Rosen, Elizabeth A. Wang, Josephine S. D'alessandro, Rodney M. Hewick, David I. Israel, P LaPan, M Bauduy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 87(6)
We have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ffb9595ba5c9af70ce108c563a863
https://pubmed.ncbi.nlm.nih.gov/2315314
https://pubmed.ncbi.nlm.nih.gov/2315314
Autor:
Charles B. Shoemaker, Allan Mufson, Kenneth Jacobs, Edward Fritsch, Takaji Miyake, Tomoe Shimizu, Jasbir Seehra, Rodney M. Hewick, Simon S. Jones, Randal J. Kaufman, Makoto Kawakita, Richard Rudersdorf, Suzanne D. Neill
Publikováno v:
Nature. 313:806-810
The glycoprotein hormone erythropoietin regulates the level of oxygen in the blood by modulating the number of circulating erythrocytes, and is produced in the kidney or liver of adult and the liver of fetal or neonatal mammals. Neither the precise c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd55f361428e8cdff3a361fda52459b1
https://doi.org/10.1038/313806a0
https://doi.org/10.1038/313806a0