Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Rodney K. Murphey"'
Publikováno v:
The Journal of Neuroscience. 34:5416-5430
Netrin and its receptor, Frazzled, dictate the strength of synaptic connections in the giant fiber system (GFS) ofDrosophila melanogasterby regulating gap junction localization in the presynaptic terminal. InNetrinmutant animals, the synaptic couplin
Publikováno v:
Neural Development
During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR proteins (co
Publikováno v:
The Journal of Neuroscience. 28:8615-8623
The signaling mechanisms that allow the conversion of a growth cone into a mature and stable synapse are yet to be completely understood. Ubiquitination plays key regulatory roles in synaptic development and may be involved in this process. Previous
Autor:
Marcus J. Allen, Rodney K. Murphey
Publikováno v:
European Journal of Neuroscience. 26:439-445
The largest central synapse in adult Drosophila is a mixed electro-chemical synapse whose gap junctions require the product of the shaking-B (shak-B) gene. Shak-B2 mutant flies lack gap junctions at this synapse, which is between the giant fibre (GF)
Autor:
P. Caruccio, Kevin G. Moffat, Xiaoliang Shan, Rodney K. Murphey, Stephan J. Froggett, Marcus J. Allen
Publikováno v:
The Journal of Neuroscience. 19:9374-9384
Glued1(Gl1) mutants produce a truncated protein that acts as a poison subunit and disables the cytoplasmic retrograde motor dynein. Heterozygous mutants have axonal defects in the adult eye and the nervous system. Here we show that selective expressi
Autor:
Kathleen A. Killian, Rodney K. Murphey
Publikováno v:
Journal of Neurobiology. 37:700-714
We investigated the role of retrograde signals in the regulation of short-term synaptic depression and facilitation by characterizing the form of plasticity expressed at novel synapses on four giant interneurons in the cricket cercal sensory system.
Publikováno v:
The Journal of Neuroscience. 18:8955-8964
On repetitive stimulation, the strength of a reflex controlling leg position inDrosophiladecreased, and this response decrement conformed to the parametric features of habituation. To study the presynaptic function of CaMKII in this nonassociative fo
Publikováno v:
Journal of Neurobiology. 33:711-723
A dominant negative mutation, Glued1, that codes for a component of the dynactin complex, disrupted the axonal anatomy of leg sensory neurons in Drosophila. To examine neuron structure in mutant animals, a P[Gal4] enhancer trap targeted expression of
Publikováno v:
Development. 122:2955-2963
Mutations in an 8 kDa (8 ×103Mr) cytoplasmic dynein light chain disrupt sensory axon trajectories in the imaginal nervous system of Drosophila. Weak alleles are behaviorally mutant, female-sterile and exhibit bristle thinning and bristle loss. Null
Autor:
Rodney K. Murphey, G. Kämper
Publikováno v:
Comparative Biochemistry and Physiology Part A: Physiology. 109:23-32
Growth and refinement of nervous system function occurs during postembryonic development in both invertebrates and vertebrates. Here we focus on one example, the cereal sensory system of orthopteran insects. Comparative studies on the different cerea