Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Rodney K Tweten"'
Autor:
Andrea L Herrera, Christopher Van Hove, Mary Hanson, James B Dale, Rodney K Tweten, Victor C Huber, Diego Diel, Michael S Chaussee
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235139 (2020)
Viral infections complicated by a bacterial infection are typically referred to as coinfections or superinfections. Streptococcus pyogenes, the group A streptococcus (GAS), is not the most common bacteria associated with influenza A virus (IAV) super
Externí odkaz:
https://doaj.org/article/2c418d96b3b144f8aca7dc263a00005a
Autor:
Hunter L. Abrahamsen, Tristan C. Sanford, Casie E. Collamore, Bronte A. Johnstone, Michael J. Coyne, Leonor García-Bayona, Michelle P. Christie, Jordan C. Evans, Allison J. Farrand, Katia Flores, Craig J. Morton, Michael W. Parker, Laurie E. Comstock, Rodney K. Tweten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-forming toxins produced by Gram-positive bacteria, which are used to attack eukaryotic cells. Here, we functionally characterize a family of 2-component CDC-like (CDCL)
Externí odkaz:
https://doaj.org/article/fa81631103bf486aa966a456bbef1768
Autor:
Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby H P Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda A K Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone
Publikováno v:
PLoS Biology, Vol 13, Iss 2, p e1002049 (2015)
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transiti
Externí odkaz:
https://doaj.org/article/61da81d52f214c008c291f4ba889cd9a
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004353 (2014)
Streptococcus pneumoniae produces the pore-forming toxin pneumolysin (PLY), which is a member of the cholesterol-dependent cytolysin (CDC) family of toxins. The CDCs recognize and bind the 3β-hydroxyl group of cholesterol at the cell surface, which
Externí odkaz:
https://doaj.org/article/dc1d387c1f1742e193d7c8316e5850e4
Autor:
Richard M Harvey, Catherine E Hughes, Adrienne W Paton, Claudia Trappetti, Rodney K Tweten, James C Paton
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103625 (2014)
Streptococcus pneumoniae is the world's leading cause of pneumonia, bacteremia, meningitis and otitis media. A major pneumococcal virulence factor is the cholesterol-dependent cytolysin, which has the defining property of forming pores in cholesterol
Externí odkaz:
https://doaj.org/article/1010bafb2feb419e9f9610a763644e5b
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002787 (2012)
The cholesterol-dependent cytolysins (CDCs) constitute a family of pore-forming toxins that contribute to the pathogenesis of a large number of Gram-positive bacterial pathogens.The most highly conserved region in the primary structure of the CDCs is
Externí odkaz:
https://doaj.org/article/15a9ce5b57074db096bc795d98ab6d1f
Autor:
Stephen Vadia, Eusondia Arnett, Anne-Cécile Haghighat, Elisabeth M Wilson-Kubalek, Rodney K Tweten, Stephanie Seveau
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002356 (2011)
Intracellular pathogens have evolved diverse strategies to invade and survive within host cells. Among the most studied facultative intracellular pathogens, Listeria monocytogenes is known to express two invasins-InlA and InlB-that induce bacterial i
Externí odkaz:
https://doaj.org/article/310b350d4cfd4f7c9606eae8cd4a4437
Autor:
Jordan C. Evans, Valentina Laclare McEneany, Michael J. Coyne, Elizabeth P. Caldwell, Madeline L. Sheahan, Salena S. Von, Emily M. Coyne, Rodney K. Tweten, Laurie E. Comstock
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The bacterium Phocaeicola vulgatus is commonly found in the human gut. Here, the authors show that the microorganism produces an antibacterial toxin that targets the LPS core glycan of closely related species and induces a response that partially pro
Externí odkaz:
https://doaj.org/article/69744958344440f3b702e995fc9d50c8
Autor:
Bronte A. Johnstone, Riya Joseph, Michelle P. Christie, Craig J. Morton, Conall McGuiness, James C. Walsh, Till Böcking, Rodney K. Tweten, Michael W. Parker
Publikováno v:
IUBMB Life. 74:1169-1179
The cholesterol-dependent cytolysins (CDCs) are a major family of bacterial pore-forming proteins secreted as virulence factors by Gram-positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol
Autor:
Abhay R. Satoskar, Stephen Vadia, Rodney K. Tweten, Stephanie Seveau, Sanjay Varikuti, Christopher Phelps, Prosper N. Boyaka, Purnima Dubey, Zayed Attia
Publikováno v:
Vaccine
Listeria monocytogenes is a facultative intracellular pathogen responsible for the life-threatening disease listeriosis. The pore-forming toxin listeriolysin O (LLO) is a critical virulence factor that plays a major role in the L. monocytogenes intra