Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Rodney G. Wilkinson"'
1
Interactions between acetylcholinesterase and tetra-N-alkylammonium ions
Autor: Rodney G. Wilkinson, David J. Sellers, P. Watts
Publikováno v: Biochemical Pharmacology. 32:787-793
A study of the mechanism of interaction of acetylcholinesterase with some simple tetra-N-alkyammonium ions has been made. Kinetic schemes have been proposed which are consistent with the experimental results observed in the enzyme-tetra-N-alkylammoni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431e09692b8de33bc678aadb91d10f6b
https://doi.org/10.1016/0006-2952(83)90577-4
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5
A comparison of methods for measuring acetyl cholinesterase activity in blood samples inhibited by carbamates
Autor: Rodney G. Wilkinson, David J. Sellers, Mary C. French
Publikováno v: Biochemical pharmacology. 26(13)
An unambiguous method based on the measurement of the acetylcholinesterase activity resulting from complete decarbamoylation of the acetylcholinesterase in blood samples inhibited by a carbamate is described and compared with a spectrophotometric mod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4978f5c500173d97bc9806960f4c7f0
https://pubmed.ncbi.nlm.nih.gov/880272
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6
The interaction of 4-alkyl derivatives of 2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes with cyclic adenosine 3',5'-monophosphate phosphodiesterase, and with cyclic adenosine 3',5'-monophosphate binding proteins
Autor: D.B. Coult, Rodney G. Wilkinson
Publikováno v: Biochemical pharmacology. 26(9)
4-Alkyl-2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes are weak competitive inhibitors of the high- K m form of cyclic adenosine 3′,5′-monophosphate phosphodiesterase (PDE) and non-competitive inhibitors of the low- K m form enzyme. The possibilit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d100cee369effee509db734da187214
https://pubmed.ncbi.nlm.nih.gov/193519
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7
The interaction of carbamates with acetylcholinesterase
Autor: P. Watts, Rodney G. Wilkinson
Publikováno v: Biochemical pharmacology. 26(8)
It has been shown that the kinetic schemes proposed by earlier workers to describe the reactions of carbamates with acetylcholinesterase are incomplete. A reaction scheme has been developed and tested by the use of methyl- and dimethyl-carbamoylcholi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374db6bc52f8506f0022649a851fa0f1
https://pubmed.ncbi.nlm.nih.gov/558761
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9
Mechanistic studies in strongly basic media. Part VIII. Kinetic studies on the displacement of halide from benzyl halides by alkali-metal salts of 9-substituted fluorenes in t-butyl alcohol solution
Autor: Rodney G. Wilkinson, Donald Bethell, Colin S. Fairclough
Publikováno v: Journal of the Chemical Society, Perkin Transactions 2. :1090
The kinetics of the displacement of halide from benzyl fluoride, chloride, and bromide by alkali-metal 9-cyano-, 9-methoxycarbonyl-, and 9-phenylsulphonylfluorenides have been studied in t-butyl alcohol solution in which the salts have been shown to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2afaa74599cdc94e0ed69c9636ac6bc
https://doi.org/10.1039/p29750001090
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10
Differences in mechanisms of nucleophilic substitution at phosphorus in S-alkyl alkylphosphonothioates and S-alkyl phosphorothioates
Autor: Peter Watts, Gilbert J. Lewis, Rodney G. Wilkinson, Thomas D. Inch
Publikováno v: Journal of the Chemical Society, Chemical Communications. :500
Whereas most phosphono-derivatives are hydrolysed more rapidly by hydroxide than the corresponding phosphoro-derivatives, the reverse situation holds for S-alkyl phosphonothioates and S-alkyl phosphorothioates; this reversal of the more usual pattern
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef3377c4e8764864941649262e1ddc14
https://doi.org/10.1039/c39750000500
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