Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Rodney D, Britt"'
Autor:
Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu, Rodney D. Britt
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve airway inflammation,
Externí odkaz:
https://doaj.org/article/d2df94ebcca34c6e80606f05eb9717af
Autor:
Priyanka Banerjee, Premanand Balraj, Nilesh Sudhakar Ambhore, Sarah A. Wicher, Rodney D. Britt, Christina M. Pabelick, Y. S. Prakash, Venkatachalem Sathish
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Airway smooth muscle (ASM) is known for its role in asthma exacerbations characterized by acute bronchoconstriction and remodeling. The molecular mechanisms underlying multiple gene interactions regulating gene expression in asthma remain el
Externí odkaz:
https://doaj.org/article/8b34563885034ee5adaba98fb6aef59d
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Type 2-high severe asthma is described as a distinct endotype with Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. While the inflammatory milieu is similar to mild asthma, patients
Externí odkaz:
https://doaj.org/article/58ce66a881434b29844e4ebaaada7c70
Autor:
Rodney D. Britt, Ned Porter, Mitchell H. Grayson, Kymberly M. Gowdy, Megan Ballinger, Kara Wada, Hye-Young Kim, Mireia Guerau-de-Arellano
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:47-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073b47617592c33336e9d4ac1824bbc0
https://doi.org/10.1016/j.jaci.2022.09.025
https://doi.org/10.1016/j.jaci.2022.09.025
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1335 (2021)
Corticosteroid insensitivity is a key characteristic of patients with severe asthma and COPD. These individuals experience greater pulmonary oxidative stress and inflammation, which contribute to diminished lung function and frequent exacerbations de
Externí odkaz:
https://doaj.org/article/7b93598c66df4a75b9b3b55c5544e4cc
Publikováno v:
Trends in Immunology. 43:792-799
While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and ast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe10c0d1f6ed7ce4fca1a6ed2a2cd57
https://doi.org/10.1016/j.it.2022.08.003
https://doi.org/10.1016/j.it.2022.08.003
Autor:
Shahid Sheikh, Rodney D. Britt, Nancy A. Ryan‐Wenger, Aiman Q. Khan, Brandon W. Lewis, Courtney Gushue, Hazel Ozuna, Devi Jaganathan, Karen McCoy, Benjamin T. Kopp
Publikováno v:
Pediatric pulmonology.
Cystic fibrosis (CF) is a multisystem disease with progressive deterioration. Recently, CF transmembrane conductance regulator (CFTR) modulator therapies were introduced that repair underlying protein defects. Objective of this study was to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89498d1e3429de33948318024cd921b1
https://pubmed.ncbi.nlm.nih.gov/36444736
https://pubmed.ncbi.nlm.nih.gov/36444736
Autor:
Rodney D. Britt, Y. S. Prakash, Venkatachalem Sathish, Christina M. Pabelick, S.A. Wicher, Priyanka Banerjee, Nilesh Sudhakar Ambhore, Premanand Balraj
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Airway smooth muscle (ASM) is known for its role in asthma exacerbations characterized by acute bronchoconstriction and remodeling. The molecular mechanisms underlying multiple gene interactions regulating gene expression in asthma remain elusive. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079b78bccf52bae227e6e76f87801cc4
https://doaj.org/article/8b34563885034ee5adaba98fb6aef59d
https://doaj.org/article/8b34563885034ee5adaba98fb6aef59d
Autor:
Stephanie A. Amici, Brandon W Lewis, Joshua A. Englert, Aiman Khan, Mireia Guerau-de-Arellano, Kymberly M Gowdy, Rodney D. Britt, Emily M. Shalosky, Joshua Walum, Michell H Grayson, Hye-Young H. Kim, Ned A. Porter
Publikováno v:
J Immunol
Severe asthma is characterized by steroid insensitivity and poor symptom control and is responsible for most asthma-related hospital costs. Therapeutic options remain limited, in part due to limited understanding of mechanisms driving severe asthma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a9bf862b714439e4fc4d8201fda0b4
https://europepmc.org/articles/PMC9055570/
https://europepmc.org/articles/PMC9055570/
Publikováno v:
International Journal of Molecular Sciences. 24:6347
Asthma in elderly populations is an increasing health problem that is accompanied by diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs, corticosteroids are commonly used to reduce lung inflammation, improve lung f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1b28fbb84690290d448f9085a5be0d
https://doi.org/10.3390/ijms24076347
https://doi.org/10.3390/ijms24076347