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pro vyhledávání: '"Rodney Claude"'
Autor:
Jie Jiang, Sankalp Srivastava, Sheng Liu, Gretchen Seim, Rodney Claude, Minghua Zhong, Sha Cao, Utpal Davé, Reuben Kapur, Amber L. Mosley, Chi Zhang, Jun Wan, Jing Fan, Ji Zhang
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106425- (2023)
Summary: Intracellular α-ketoglutarate is an indispensable substrate for the Jumonji family of histone demethylases (JHDMs) mediating most of the histone demethylation reactions. Since α-ketoglutarate is an intermediate of the tricarboxylic acid cy
Externí odkaz:
https://doaj.org/article/e5002eac7ce4453eb8015dfa668b7a61
Autor:
Ji Zhang, Rodney Claude, Sankalp Srivastava, Sandeep Batra, Minghua Zhong, Utpal Dave, Ronald C. Wek
Publikováno v:
Molecular Cancer Research. 21:A012-A012
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, affecting the lymphoid cells of both B and T lineages. Most ALL cells are auxotrophic for asparagine, a nonessential amino acid for protein synthesis, due to the low expression o