Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rodney Caughren Schnur"'
Autor:
Roberto Jorge Bitton, Edward G. Mimnaugh, Luke Whitesell, Len Neckers, Rodney Caughren Schnur, Jane B. Trepel, Phongmai Nguyen, James D. Moyer, Penny Miller, Christine Chavany
Publikováno v:
Journal of Biological Chemistry. 271:4974-4977
Treatment of SKBr3 cells with benzoquinone ansamycins, such as geldanamycin (GA), depletes p185erbB2, the receptor tyrosine kinase encoded by the erbB2 gene. In the same cells, a biologically active benzoquinone photoaffinity label specifically binds
Autor:
Rodney Caughren Schnur, M L Muzzi, J L Doty, B A Cooper, Randall James Gallaschun, M F Dee, E G Barbacci, James D. Moyer, Michael L. Corman, C I DiOrio
Publikováno v:
Journal of Medicinal Chemistry. 38:3806-3812
The erbB-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when overexpressed in breast, ovarian, and gastric cancers. Naturally occurring benzoquinoid ansamycin antib
Publikováno v:
Biochemical and Biophysical Research Communications. 201:1313-1319
Several benzoquinoid ansamycins, e.g.,herbimycin A and geldanamycin, have been widely used as inhibitors of tyrosine kinases. We recently reported that exposure to herbimycin A and several analogs depletes the erbB2 gene product p185 in human breast
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:529-535
An azido-125iodo-ansamycin (1) in the geldanamycin family was prepared in two steps in one reacton vessel from 17-amino-22-(4′-aminophenacyl)-17-demethoxygeldanamycin (3). The title compound was suitable for photoaffinity labeling proteins that int
Publikováno v:
The Journal of Organic Chemistry. 59:2581-2584
Ansamycin ring modifications in the geldanamycin oncogene inhibitor series were investigated. A carbamate to urea interchange was accomplished with net retention at the 7(S)-center of a geldanamycin analog. This chirally specific transformation was e
Publikováno v:
ChemInform. 22
N-(5-Fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxam ide (1) is a member of a series of amides found to substantially increase lifespan in mice bearing established micrometastatic 3LL Lewis lung carcinoma. Amide 1 is effective after either or
Publikováno v:
ChemInform. 23
Two novel tricyclic ring systems were designed as serine protease inhibitors and synthesized from oxindoles; the first series, 1,3-oxazino[6,5-b]indole-2,4-(3H,9H)-diones, were prepared from 2,3-dihydro-2-oxo-(1H)-indole-3-carboxamides and phosgene i
Autor:
Jay M. Bergeron, James A. Retsema, Laura J. L. Norcia, Shigeru F. Hayashi, John P. Dirlam, Rodney Caughren Schnur, Annette M. Silvia
Publikováno v:
ChemInform. 31
Two cyclic homopentapeptides, CP-101,680 and CP-163,234 [6a-(3',4'-dichlorophenylamino) analogs of viomycin and capreomycin, respectively], were identified as novel antibacterial agents for the treatment of animal disease, especially for livestock re
Publikováno v:
Journal of Heterocyclic Chemistry. 29:369-373
Two novel tricyclic ring systems were designed as serine protease inhibitors and synthesized from oxindoles; the first series, 1,3-oxazino[6,5-b]indole-2,4-(3H,9H)-diones, were prepared from 2,3-dihydro-2-oxo-(1H)-indole-3-carboxamides and phosgene i
Publikováno v:
Journal of Heterocyclic Chemistry. 27:963-966
Two novel tricyclic ring systems derived from 3-benzazepines were synthesized; the first, a 6,7,5-ring, 1H-imidazo[5,1-b][3]benzazepine-1,3(2H)-dione was obtained using an unusual Stiles reaction while the second, an analogous 6,7,6-ring, pyrimido[6,