Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rodney C. Young"'
Publikováno v:
ChemInform. 22
Regioselective cleavages of the myo-inositol monoorthoformate (2) and a rearrangement of the acetal (5) are reported.
Publikováno v:
Carbohydrate Research. 234:117-130
Reduction of 2,4,6-tri-O-benzyl- dl -myo-inositol 1,3,5-orthoformate (1) with di-isobutylaluminium hydride gave 2,4,6-tri-O-benzyl-1,3-O-methylene- dl -myo-inositol (2), whereas reaction with trimethylaluminium gave 2,4,6-tri-O-benzyl-1,5-O-ethyliden
Autor:
Eggleston Ds, CP Downes, Martin Jones, C.H. Macphee, Kishore K. Rana, Rodney C. Young, John G. Ward
Publikováno v:
Journal of Medicinal Chemistry. 33:641-646
A new and convenient method for the preparation of the four stereoisomers of dihexadecanoyl phosphatidylinositol has been developed. An enantiomeric pair of acid-labile, pentaprotected myo-inositol building blocks was synthesized in high yield and co
Publikováno v:
Medical Science Symposia Series ISBN: 9789401048491
To select an antagonist as a tool for 5-HT4 receptor blockade we investigated the affinity of three compounds for 5-HT4 receptors and 5-HT3 receptors. SB 203186 ([1-piperidinyl] ethyl 1H-indole 3-carboxylate) was a more potent antagonist (pKB= 8.26)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d897a5c9a1a234d34d258a5fce0416
https://doi.org/10.1007/978-94-011-1920-7_15
https://doi.org/10.1007/978-94-011-1920-7_15
Autor:
John G. Ward, Rodney C. Young
Publikováno v:
ACS Symposium Series ISBN: 9780841220867
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a70a3f92a6f0e73a88f050e80dbce16
https://doi.org/10.1021/bk-1991-0463.ch016
https://doi.org/10.1021/bk-1991-0463.ch016
Publikováno v:
Journal of medicinal chemistry. 33(8)
The possibility of deriving a potent, cell-penetrating inhibitor of human erythrocyte PI 4-kinase, competitive with respect to ATP, has been investigated in a series of purine derivatives and analogues. The purine nucleus is not essential for binding
Publikováno v:
Tetrahedron Letters. 31:2633-2634
Regioselective cleavages of the myo-inositol monoorthoformate (2) and a rearrangement of the acetal (5) are reported.
Autor:
R. C. Mitchell, M. L. Roantree, C. R. Ganellin, Rodney C. Young, Graham J. Durant, H. D. Prain, M. J. Graham, John Colin Emmett
Publikováno v:
Journal of Medicinal Chemistry. 29:44-49
The activities of a series of H2 receptor histamine antagonists structurally related to cimetidine (1) have been compared to investigate the effect of replacing the cyanoguanidine moiety by other neutral, dipolar groups. Antagonist activity, as measu
Publikováno v:
Journal of Medicinal Chemistry. 30:1150-1156
A series of analogues of the H2 receptor histamine antagonist cimetidine have been synthesized in which the dipolar cyanoguanidine group has been replaced by a number of zwitterionic moieties. Although none of the compounds is more effective than cim
Publikováno v:
Tetrahedron Letters. 30:5353-5356
Short and convenient syntheses of PtdIns 4P and PtdIns analogues based on selective phosphorylation of (+)-2,3:5,6-di- O -isopropylidene- myo -inositol are presented.