Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Rodney A Stewart"'
Autor:
Madison F Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Annabel Lee, Alyssa B Long, Mattie J Casey, Abhishek Poddar, Isaac B Nelson, Corvin D Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M Kwan, Stefan Schulz, Rodney A Stewart, John J G Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R Myers
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002685 (2024)
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and physically
Externí odkaz:
https://doaj.org/article/dd4df563bde8484e9cf388d6a8c3f333
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195291 (2018)
3D printing is an emergent manufacturing technology recently being applied in the medical field for the development of custom bone prostheses and scaffolds. However, successful industry transformation to this new design and manufacturing approach req
Externí odkaz:
https://doaj.org/article/c3c4a2d8548948cd8ffe309eb51522e5
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167278 (2016)
The neural crest (NC) is a stem cell-like embryonic population that is essential for generating and patterning the vertebrate body, including the craniofacial skeleton and peripheral nervous system. Defects in NC development underlie many birth defec
Externí odkaz:
https://doaj.org/article/7184762ac5bb4cf18827856464c525b4
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004946 (2015)
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, including the craniofacial skeleton. Extensive filopodial protrusions in NC cells are thought to sense chemo-attractive/repulsive signals that provide
Externí odkaz:
https://doaj.org/article/85552832a5dc480990cc0b2df93777ab
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88151 (2014)
Ionizing radiation (IR)-induced DNA double-strand breaks trigger an extensive cellular signaling response that involves the coordination of hundreds of proteins to regulate DNA repair, cell cycle arrest and apoptotic pathways. The cellular outcome of
Externí odkaz:
https://doaj.org/article/17c16749382a4e79a379492a5e15c0a4
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003533 (2013)
Heterozygous germline mutations and deletions in PHOX2B, a key regulator of autonomic neuron development, predispose to neuroblastoma, a tumor of the peripheral sympathetic nervous system. To gain insight into the oncogenic mechanisms engaged by thes
Externí odkaz:
https://doaj.org/article/455d346e2d2b449b98bf32b2a6571a5d
Autor:
Shelly Sorrells, Seth Carbonneau, Erik Harrington, Aye T Chen, Bridgid Hast, Brett Milash, Ujwal Pyati, Michael B Major, Yi Zhou, Leonard I Zon, Rodney A Stewart, A Thomas Look, Cicely Jette
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002922 (2012)
DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful eli
Externí odkaz:
https://doaj.org/article/1b9c52b106054d52a603a166423650ef
Autor:
Danielle A Murphy, Begoña Diaz, Paul A Bromann, Jeff H Tsai, Yasuhiko Kawakami, Jochen Maurer, Rodney A Stewart, Juan Carlos Izpisúa-Belmonte, Sara A Courtneidge
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22499 (2011)
In the adult organism, cell migration is required for physiological processes such as angiogenesis and immune surveillance, as well as pathological events such as tumor metastasis. The adaptor protein and Src substrate Tks5 is necessary for cancer ce
Externí odkaz:
https://doaj.org/article/c1bec8cc888f4a888f13b67766d53af7
Autor:
Ivo Daniel, Newsha K. Ajami, Andrea Castelletti, Dragan Savic, Rodney A. Stewart, Andrea Cominola
Publikováno v:
npj Clean Water, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Climate change and urbanization challenge utilities’ pursuit of water security worldwide. While water utilities are directly impacted by climate change, their operations also contribute to greenhouse gas emissions. Digital technologies hav
Externí odkaz:
https://doaj.org/article/9d0dcaac5cb14457acb1b0b24b76c86e
Autor:
Mattie J. Casey, Alexandra M. Call, Annika V. Thorpe, Cicely A. Jette, Michael E. Engel, Rodney A. Stewart
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105737- (2023)
Summary: Lsd1/Kdm1a functions both as a histone demethylase enzyme and as a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression. The relative contributions of Lsd1’s demethylase and scaffolding
Externí odkaz:
https://doaj.org/article/e4086ce0d1e44269a796aa91edc20947