Lestaurtinib's antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer.

Autor: Rodman EPB, Emch MJ, Hou X, Bajaj A, Pearson NA, John AJ, Ortiz Y, Bass AD, Singh S, Baldassarre G, Kaufmann SH, Weroha SJ, Hawse JR

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 09. Date of Electronic Publication: 2024 Jun 09.

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer.

Autor: Aspros KGM; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Carter JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA., Hoskin TL; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Suman VJ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Subramaniam M; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Emch MJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Ye Z; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Sun Z; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Sinnwell JP; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Thompson KJ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Tang X; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Rodman EPB; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Wang X; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Nelson AW; Cancer Research UK Cambridge Research Institute, University of Cambridge, Cambridge, UK., Chernukhin I; Cancer Research UK Cambridge Research Institute, University of Cambridge, Cambridge, UK., Hamdan FH; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Bruinsma ES; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., Carroll JS; Cancer Research UK Cambridge Research Institute, University of Cambridge, Cambridge, UK., Fernandez-Zapico ME; Shulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, 55905, USA., Johnsen SA; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Kalari KR; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Urology, Mayo Clinic, Rochester, MN, 55905, USA., Leon-Ferre RA; Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA., Couch FJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA., Ingle JN; Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA., Goetz MP; Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA., Hawse JR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA. Hawse.John@mayo.edu.

Publikováno v: NPJ breast cancer [NPJ Breast Cancer] 2022 Feb 17; Vol. 8 (1), pp. 20. Date of Electronic Publication: 2022 Feb 17.