Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease.

Autor: Coffey SR; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America., Bragg RM; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America., Minnig S; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America., Ament SA; Institute for Genome Sciences and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Institute for Systems Biology, Seattle, WA, United States of America., Cantle JP; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America., Glickenhaus A; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America., Shelnut D; Department of Mathematics, Western Washington University, Bellingham, WA, United States of America., Carrillo JM; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America., Shuttleworth DD; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America., Rodier JA; INSERM U1216, Grenoble Institute of Neuroscience, Grenoble, France. Université Grenoble Alpes, Grenoble, France., Noguchi K; Department of Mathematics, Western Washington University, Bellingham, WA, United States of America., Bennett CF; Ionis Pharmaceuticals, Carlsbad, CA, United States of America., Price ND; Institute for Genome Sciences and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States of America., Kordasiewicz HB; Ionis Pharmaceuticals, Carlsbad, CA, United States of America., Carroll JB; Behavioral Neuroscience Program, Psychology Department, Western Washington University, Bellingham, WA, United States of America.

Publikováno v: PloS one [PLoS One] 2017 Apr 28; Vol. 12 (4), pp. e0175968. Date of Electronic Publication: 2017 Apr 28 (Print Publication: 2017).