Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Rodger P. Mcever"'
Autor:
Yuji Kondo, Jason L. Larabee, Liang Gao, Huiping Shi, Bojing Shao, Christopher M. Hoover, J. Michael McDaniel, Yen-Chun Ho, Robert Silasi-Mansat, Stephanie A. Archer-Hartmann, Parastoo Azadi, R. Sathish Srinivasan, Alireza R. Rezaie, Alain Borczuk, Jeffrey C. Laurence, Florea Lupu, Jasimuddin Ahamed, Rodger P. McEver, James F. Papin, Zhongxin Yu, Lijun Xia
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a pandemic. Severe disease is associated with dysfunction of multiple organs, but some infected cells do not express ACE2, the canoni
Externí odkaz:
https://doaj.org/article/3801c57ff82e4a0eac422412dabc3d90
Publikováno v:
Blood Advances, Vol 2, Iss 7, Pp 731-744 (2018)
Abstract: Rolling neutrophils receive signals while engaging P- and E-selectin and chemokines on inflamed endothelium. Selectin signaling activates β2 integrins to slow rolling velocities. Chemokine signaling activates β2 integrins to cause arrest.
Externí odkaz:
https://doaj.org/article/3e0d92658f92444b97876ea6f581dc7d
Autor:
Zhenghui Liu, Tadayuki Yago, Nan Zhang, Sumith R. Panicker, Ying Wang, Longbiao Yao, Padmaja Mehta-D’souza, Lijun Xia, Cheng Zhu, Rodger P. McEver
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Neutrophil adhesion is tightly regulated to enforce protective immunity, but it is unclear how mechanochemical processes such as catch bonds and slip bonds modulate neutrophilsin vivo. Here the authors show that a point mutation in the adhesion molec
Externí odkaz:
https://doaj.org/article/c0e7f746127e4600a846c356bdd5181b
Autor:
Venu Lagishetty, Lijun Xia, Courtney W. Houchen, Justin L. Sonnenburg, Timothy M. Griffin, Liang Gao, David Casero, Negin Kazemian, Rodger P. McEver, J. Michael McDaniel, Bojing Shao, Sepideh Pakpour, Samuel McGee, Jonathan Braun, Chinthalapally V. Rao, Kirk Bergstrom, Christopher M. Hoover, Wesley F. Zandberg, Jonathan P. Jacobs, Albert Batushansky, Xindi Shan, Yuji Kondo, Benjamin Noyovitz, Deanna L. Gibson
Publikováno v:
Science (New York, N.Y.), vol 370, iss 6515
Science
Science
So much more to mucus Mammals accommodate a dense community of metabolically active microorganisms in their gut. This is not a passive relationship, and host and microbe have antagonistic as well as mutualistic responses to each other. Using a whole-
Publikováno v:
Blood Adv
Ezrin/radixin/moesin (ERM) proteins are adaptors that link the actin cytoskeleton to the cytoplasmic domains of membrane proteins. Leukocytes express mostly moesin with lower levels of ezrin but no radixin. When leukocytes are activated, ERMs are pos
Autor:
Kaitao Li, Rodger P. McEver, Veronika I. Zarnitsyna, Fangyuan Zhou, Hang Lu, Zhou Yuan, Fang Zhang, Cheng Zhu, Larissa Doudy
Publikováno v:
J Cell Sci
Selectins and integrins are key players in the adhesion and signaling cascade that recruits leukocytes to inflamed tissues. Selectin binding induces β2 integrin binding to slow leukocyte rolling. Here, a micropipette was used to characterize neutrop
Autor:
Lijun Xia, Yuji Kondo, Christopher Hoover, Wolfgang Bergmeier, Rodger P. McEver, Samuel McGee, Michael McDaniel, Sidney W. Whiteheart, Robert H. Lee, Bojing Shao
Publikováno v:
Blood. 137(20)
During early embryonic development in mammals, including humans and mice, megakaryocytes (Mks) first originate from primitive hematopoiesis in the yolk sac. These embryonic Mks (eMks) circulate in the vasculature with unclear function. Herein, we rep
Autor:
Yan Zhang, Ning Jiang, Veronika I Zarnitsyna, Arkadiusz G Klopocki, Rodger P McEver, Cheng Zhu
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57202 (2013)
Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury. P-selectin dimerizes on the surface of endothelial cells an
Externí odkaz:
https://doaj.org/article/4c94e86ded3e41579aee661030a7d079
Publikováno v:
Blood. 132:1426-1437
Inflammation is a major contributor to deep vein thrombosis (DVT). Flow restriction of the inferior vena cava (IVC) in mice induces DVT like that in humans. In this model, P-selectin–dependent adhesion of neutrophils and monocytes leads to release
Publikováno v:
Blood Advances. 2:731-744
Rolling neutrophils receive signals while engaging P- and E-selectin and chemokines on inflamed endothelium. Selectin signaling activates β2 integrins to slow rolling velocities. Chemokine signaling activates β2 integrins to cause arrest. Despite e