Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Rodger A. Liddle"'
Autor:
Sandip M. Swain, Rodger A. Liddle
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this process is an inherent property of all cells
Externí odkaz:
https://doaj.org/article/9366e91fc0434b138a1356afad200300
Autor:
Rodger A. Liddle
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Visceral pain associated with irritable bowel syndrome afflicts 15% of the US population. Although treatments are limited, guanylyl cyclase C (GUCY2C) agonists alleviate pain and constipation. Until now, it was assumed that the activation of GUCY2C a
Externí odkaz:
https://doaj.org/article/3824a2f8d8444b5d87284c8fd2fde29c
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure. W
Externí odkaz:
https://doaj.org/article/059755caf1ba4f22bbb7543e75eea4c1
Autor:
Rodger A. Liddle
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 739-747 (2019)
Enteroendocrine cells (EECs) are sensory cells of the gastrointestinal tract. Most EECs reside in the mucosal lining of the stomach or intestine and sense food in the gut lumen. Food signals stimulate the release of hormones into the paracellular spa
Externí odkaz:
https://doaj.org/article/9844efa5eec448fd9434be2ae9ba2d1c
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Manipulation of the pancreas during surgery can induce acute pancreatitis due to zymogen activation. Here the authors show that the mechanoreceptor Piezo1 is activated by pressure and its activation leads to calcium dependent pancreatic injury wherea
Externí odkaz:
https://doaj.org/article/10e1a87d36af415ca7fb7de77dc16ef2
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 1, Pp 75-86 (2015)
Background & Aims: In the pancreas, activation of primary sensory nerves through the transient receptor potential vanilloid-1 (TRPV1) ion channel contributes to the early stages of development of pancreatitis. Little is known about the mechanism by w
Externí odkaz:
https://doaj.org/article/9112013b52c6468599965b6903b23e82
Autor:
Rodger A. Liddle, MD
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 1, Pp 6-7 (2017)
Externí odkaz:
https://doaj.org/article/cf39ae3951ec40eb80b193a18c6cfdff
Autor:
Bryan L. Balmadrid, Catherine M. Thomas, Cynthia J. Coffman, Rodger A. Liddle, Deborah A. Fisher
Publikováno v:
Journal of Cancer Epidemiology, Vol 2012 (2012)
Background. Gastrointestinal (GI) neuroendocrine tumor (NET) incidence has been increasing; however, GI NET within the national Veterans Affairs (VA) health system has not been described. Methods. We used the VA Central Cancer Registry to identify th
Externí odkaz:
https://doaj.org/article/2b6f6f688fa3436884a786451f11ed2f
Publikováno v:
eLife, Vol 8 (2019)
Enteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that sense and transduce nutrient information. Consumption of dietary fat contributes to metabolic disorders, but EEC adaptations to high fat feeding were unknown
Externí odkaz:
https://doaj.org/article/77c100c778dd4570a0002b83b2ede619
Autor:
Ahmad Farooq, Liliana Hernandez, Sandip M. Swain, Rafiq A. Shahid, Joelle M.-J. Romac, Steven R. Vigna, Rodger A. Liddle
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Proper mitochondrial function and adequate cellular ATP are necessary for normal pancreatic protein synthesis and sorting, maintenance of intracellular organelles and enzyme secretion. Inorganic phosphate is required for generating ATP and its limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca875f32dc2a88563072e4942703afb0
https://doi.org/10.1152/ajpgi.00022.2022
https://doi.org/10.1152/ajpgi.00022.2022