Zobrazeno 1 - 10
of 834
pro vyhledávání: '"Roderick T, Bronson"'
Autor:
Gloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q. Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P. Duncan, Zachary R. Sechrist, Diana Agostini-Vulaj, Xenia L. Schafer, Hayley Chang, Zachary R. Smith, Thomas N. O’Connor, Sarah Whelan, Laura M. Selfors, Jett Crowdis, G. Kenneth Gray, Roderick T. Bronson, Dirk Brenner, Alessandro Rufini, Robert T. Dirksen, Aram F. Hezel, Aaron R. Huber, Joshua Munger, Benjamin F. Cravatt, Vasilis Vasiliou, Calvin L. Cole, Gina M. DeNicola, Isaac S. Harris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many dise
Externí odkaz:
https://doaj.org/article/8f2b42686a084979a860c07d826515fd
Autor:
Weimin Guo, Edwin F. Ortega, Dayong Wu, Lijun Li, Roderick T. Bronson, Sarah K. Boehm, Simin Nikbin Meydani
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
ObjectiveEpidemiological studies suggest that consumption of fruits and vegetables (FV) is negatively associated with the incidence of certain cancers and mortality. However, a causal relationship has not been demonstrated. Thus, we investigated the
Externí odkaz:
https://doaj.org/article/a7fdbe95f27b4a98875deae5f7c139c3
Autor:
Aina He, Songhai Tian, Oded Kopper, Daniel J Horan, Peng Chen, Roderick T Bronson, Ren Sheng, Hao Wu, Lufei Sui, Kun Zhou, Liang Tao, Quan Wu, Yujing Huang, Zan Shen, Sen Han, Xueqing Chen, Hong Chen, Xi He, Alexander G Robling, Rongsheng Jin, Hans Clevers, Dongxi Xiang, Zhe Li, Min Dong
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002353 (2023)
Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting Wnt signaling pathways reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by th
Externí odkaz:
https://doaj.org/article/c1f3079f1d4342a0a3d6ba9ffe231f87
Autor:
Rupesh S. Patel, Rodrigo Romero, Emma V. Watson, Anthony C. Liang, Megan Burger, Peter M. K. Westcott, Kim L. Mercer, Roderick T. Bronson, Eric C. Wooten, Arjun Bhutkar, Tyler Jacks, Stephen J. Elledge
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
GATA-binding protein 4 (GATA4) is reported to control cell proliferation in cancers. Here the authors show that GATA4’s pro-inflammatory secretome promotes the recruitment of immune cells such as CD8 + T cells to suppress tumour initiation and grow
Externí odkaz:
https://doaj.org/article/0f7b65b8712445b997f900c25649c681
Autor:
Cameron R. Taylor, William H. Clark, Ellen G. Clarrissimeaux, Seong Ho Yeon, Matthew J. Carty, Stuart R. Lipsitz, Roderick T. Bronson, Thomas J. Roberts, Hugh M. Herr
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Human movement is accomplished through muscle contraction, yet there does not exist a portable system capable of monitoring muscle length changes in real time. To address this limitation, we previously introduced magnetomicrometry, a minimally-invasi
Externí odkaz:
https://doaj.org/article/95395378d46a4ed0aa1a422aa0ef178a
Autor:
Jason J. Zoeller, Aleksandr Vagodny, Veerle W. Daniels, Krishan Taneja, Benjamin Y. Tan, Yoko S. DeRose, Maihi Fujita, Alana L. Welm, Anthony Letai, Joel D. Leverson, Vincent Blot, Roderick T. Bronson, Deborah A. Dillon, Joan S. Brugge
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)
Abstract Background Targeted therapies for triple-negative breast cancer (TNBC) are limited; however, the epidermal growth factor receptor (EGFR) represents a potential target, as the majority of TNBC express EGFR. The purpose of these studies was to
Externí odkaz:
https://doaj.org/article/7961025b271046ca91a4d856080ab647
Autor:
Shilpa Prabhakar, Pike See Cheah, Xuan Zhang, Max Zinter, Maria Gianatasio, Eloise Hudry, Roderick T. Bronson, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Casey A. Maguire, Miguel Sena-Esteves, Bakhos A. Tannous, Xandra O. Breakefield
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 18-26 (2019)
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome caused by mutations in TSC1 or TSC2, encoding hamartin and tuberin, respectively. These proteins act as a complex that inhibits mammalian target of rapamycin (mTOR)-mediated cell growth
Externí odkaz:
https://doaj.org/article/5011cb5ccfc6461d9959126df3595260
Autor:
Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Roderick T. Bronson, Matthew G. Vander Heiden
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods In order to study the effect o
Externí odkaz:
https://doaj.org/article/3c3135e5d5674410bb51cf7b8aa97abe
Autor:
Naiara Santana-Codina, Anjali A. Roeth, Yi Zhang, Annan Yang, Oksana Mashadova, John M. Asara, Xiaoxu Wang, Roderick T. Bronson, Costas A. Lyssiotis, Haoqiang Ying, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pent
Externí odkaz:
https://doaj.org/article/54e4abc4188c4609baed834f3f363f66
Autor:
Hyun Jung Jun, Vicky A. Appleman, Hua-Jun Wu, Christopher M. Rose, Javier J. Pineda, Alan T. Yeo, Bethany Delcuze, Charlotte Lee, Aron Gyuris, Haihao Zhu, Steve Woolfenden, Agnieszka Bronisz, Ichiro Nakano, Ennio A. Chiocca, Roderick T. Bronson, Keith L. Ligon, Jann N. Sarkaria, Steve P. Gygi, Franziska Michor, Timothy J. Mitchison, Al Charest
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Amplification of PDGFRα is a common alteration in glioblastoma. In this study, the authors develop a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFR and discover Stathmin1 as an important PDGF
Externí odkaz:
https://doaj.org/article/e36e588f60e24fb6aa72e07d8947fc7d