Výsledky vyhledávání - "Roderick R McInnes"

Akademický článek

Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.

Autor: Alexa N Bramall, Michael J Szego, Laura R Pacione, Inik Chang, Eduardo Diez, Pedro D'Orleans-Juste, Duncan J Stewart, William W Hauswirth, Masashi Yanagisawa, Roderick R McInnes

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e58023 (2013)

Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR survival, we generated Edn2(-/-) mice carrying homozygous Pde6b(r

Externí odkaz: https://doaj.org/article/954d490c84c645a9acda37790434c359

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Akademický článek

Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors.

Autor: Man Tang, Evgueni Ivakine, Vivek Mahadevan, Michael W Salter, Roderick R McInnes

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51433 (2012)

Kainate receptors (KARs) are a class of ionotropic glutamate receptors that are expressed throughout the central nervous system. The function and subcellular localization of KARs are tightly regulated by accessory proteins. We have previously identif

Externí odkaz: https://doaj.org/article/ec21614981b44242a90f75645b11e2a7

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Akademický článek

A transgenic mouse line expressing cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors.

Autor: Philip E B Nickerson, Kara Ronellenfitch, Jason McEwan, Howard Kim, Roderick R McInnes, Robert L Chow

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e27145 (2011)

Approaches for manipulating cell type-specific gene expression during development depend on the identification of novel genetic tools. Here, we report the generation of a transgenic mouse line that utilizes Vsx2 upstream sequences to direct Cre recom

Externí odkaz: https://doaj.org/article/203cd1b9c32b4ae7a757c34ab321e484

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Akademický článek

Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

Autor: David Ng, Graham M Pitcher, Rachel K Szilard, Andréa Sertié, Marijana Kanisek, Steven J Clapcote, Tatiana Lipina, Lorraine V Kalia, Daisy Joo, Colin McKerlie, Miguel Cortez, John C Roder, Michael W Salter, Roderick R McInnes

Publikováno v: PLoS Biology, Vol 7, Iss 2, p e41 (2009)

The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, U

Externí odkaz: https://doaj.org/article/3b93d0508888458dabaff426a1a4130a

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The Deep Genome Project

Publikováno v: Genome biology (Online) 21 (2020): 18–24. doi:10.1186/s13059-020-1931-9
info:cnr-pdr/source/autori:Lloyd, K. C. Kent; Adams, David J.; Baynam, Gareth; Beaudet, Arthur L.; Bosch, Fatima; Boycott, Kym M.; Braun, Robert E.; Caulfield, Mark; Cohn, Ronald; Dickinson, Mary E.; Dobbie, Michael S.; Flenniken, Ann M.; Flicek, Paul; Galande, Sanjeev; Gao, Xiang; Grobler, Anne; Heaney, Jason D.; Herault, Yann; De Angelis, Martin Hrabe; Lupski, James R.; Lyonnet, Stanislas; Mallon, Ann-Marie; Mammano, Fabio; MacRae, Calum A.; McInnes, Roderick; McKerlie, Colin; Meehan, Terrence F.; Murray, Stephen A.; Nutter, Lauryl M. J.; Obata, Yuichi; Parkinson, Helen; Pepper, Michael S.; Sedlacek, Radislav; Seong, Je Kyung; Shiroishi, Toshihiko; Smedley, Damian; Tocchini-Valentini, Glauco; Valle, David; Wang, Chi-Kuang Leo; Wells, Sara; White, Jacqueline; Wurst, Wolfgang; Xu, Ying; Brown, Steve D. M./titolo:The Deep Genome Project/doi:10.1186%2Fs13059-020-1931-9/rivista:Genome biology (Online)/anno:2020/pagina_da:18/pagina_a:24/intervallo_pagine:18–24/volume:21
Genome biology, vol 21, iss 1
Genome Biology
Genome Biology, BioMed Central, 2020, 21 (1), ⟨10.1186/s13059-020-1931-9⟩
Genome biology 21(1), 18 (2020). doi:10.1186/s13059-020-1931-9
Genome Biol. 21:18 (2020)
Genome Biology, Vol 21, Iss 1, Pp 1-6 (2020)

In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, pathobiology. Enabled by technolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54646b089831921f21b0f18dc9fa7cf8
http://www.cnr.it/prodotto/i/426621

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Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition

Autor: Roderick R. McInnes, Xiaoqing Yuan, Michael W. Salter, Calvin Fang, Ramesh Chittajallu, Megan S. Wyeth, Daniel Abebe, Geoffrey A. Vargish, Vivek Mahadevan, Steven Hunt, April Johnston, Kenneth A. Pelkey, Chris J. McBain, André Fisahn

Publikováno v: Cell Reports, Vol 20, Iss 9, Pp 2156-2168 (2017)

Summary Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is GluK subunit/Neto isoform specific, such regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10e3ed51ca9d2dafa8a7207f750b8c0
https://doi.org/10.1016/j.celrep.2017.08.017

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Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons

Autor: Vivek Mahadevan, Michelle Y. Huang, Roderick R. McInnes, Andrew Puchalski, Eric Delpire, Evgueni A. Ivakine, Caiwei M. Li, Pavel Uvarov, Jonah Chevrier, Brooke A. Acton, Melanie A. Woodin, Matti S. Airaksinen, Jessica C. Pressey

Publikováno v: Cell reports
Cell Reports, Vol 7, Iss 6, Pp 1762-1770 (2014)

SUMMARY KCC2 is the neuron-specific K+-Cl− cotransporter required for maintaining low intracellular Cl−, which is essential for fast inhibitory synaptic transmission in the mature CNS. Despite the requirement of KCC2 for inhibitory synaptic trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2676547bd3fa469796da0980927b35

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Neto Auxiliary Protein Interactions Regulate Kainate and NMDA Receptor Subunit Localization at Mossy Fiber–CA3 Pyramidal Cell Synapses

Autor: Kenneth A. Pelkey, Roderick R. McInnes, Chris J. McBain, Megan S. Wyeth, Michael W. Salter, Ronald S. Petralia

Publikováno v: The Journal of Neuroscience. 34:622-628

Neto1 and Neto2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function. In the hippocampus, Neto1 enhances the amplitude and prolongs the kinetics of KAR-mediated currents at mossy fiber (MF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebde2a25f2425dc2766c0b70a6d6bbf
https://doi.org/10.1523/jneurosci.3098-13.2014

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Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

Autor: Dinesh Rakheja, Amir Rattner, Inik Chang, Stephen Joza, Alexa N. Bramall, Martin Post, Amy Greenstein Baynash, Roderick R. McInnes, Duncan J. Stewart, Masashi Yanagisawa, Colin McKerlie

Publikováno v: Journal of Clinical Investigation. 123:2643-2653

To explore the physiological functions of endothelin-2 (ET-2), we generated gene-targeted mouse models. Global Et2 knockout mice exhibited severe growth retardation and juvenile lethality. Despite normal milk intake, they suffered from internal starv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa0bc5b050043b2f9af448827920263
https://doi.org/10.1172/jci66735

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Neto2 is a KCC2 interacting protein required for neuronal Cl − regulation in hippocampal neurons

Autor: Jake Ormond, Eric Delpire, Man Tang, Evgueni A. Ivakine, Roderick R. McInnes, Brooke A. Acton, Jessica C. Pressey, Michael W. Salter, Vivek Mahadevan, Melanie A. Woodin, David Ng, Michelle Y. Huang

Publikováno v: Proceedings of the National Academy of Sciences. 110:3561-3566

KCC2 is a neuron-specific K + –Cl − cotransporter that is essential for Cl − homeostasis and fast inhibitory synaptic transmission in the mature CNS. Despite the critical role of KCC2 in neurons, the mechanisms regulating its function are not u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfa15723f3ee3ddecc77b07398d61a4
https://doi.org/10.1073/pnas.1212907110

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