The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

Autor: Tamara M Sirey, Kenny Roberts, Wilfried Haerty, Oscar Bedoya-Reina, Sebastian Rogatti-Granados, Jennifer Y Tan, Nick Li, Lisa C Heather, Roderick N Carter, Sarah Cooper, Andrew J Finch, Jimi Wills, Nicholas M Morton, Ana Claudia Marques, Chris P Ponting

Publikováno v: eLife, Vol 8 (2019)

To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and mitochondrial genomes. How an effective stoichiometry of this many constituent s

Externí odkaz: https://doaj.org/article/7203b3e44ab34c76a17f006cfd21d380

β-cell-specific glucocorticoid reactivation attenuates inflammatory β-cell destruction.

Autor: XiaoXia eLiu, Sophie eTurban, Roderick N Carter, Shakil eAhmad, Lynne eRamage, Scott P Webster, Brian R Walker, Jonathan eSeckl, Nicholas Michael Morton

Publikováno v: Frontiers in Endocrinology, Vol 5 (2014)

Progression and severity of Type 1 diabetes is dependent upon inflammatory induction of nitric oxide production and consequent pancreatic β-cell damage. Glucocorticoids are highly effective anti-inflammatory agents but have been precluded in type 1

Externí odkaz: https://doaj.org/article/f37813837557492185d79e100a8e017a

Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy

Autor: Rafal Czapiewski, Dzmitry G. Batrakou, Jose I. de las Heras, Roderick N. Carter, Aishwarya Sivakumar, Magdalena Sliwinska, Charles R. Dixon, Shaun Webb, Giovanna Lattanzi, Nicholas M. Morton, Eric C. Schirmer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Little is known how spatial genome organization is directed in fat; however, key proadipogenic genes reposition from the nuclear envelope (NE) to the interior during adipogenesis. Here the authors show that deletion of NE protein Tmem120a in adipocyt

Externí odkaz: https://doaj.org/article/5efba97324ba4758897fa78e06687621

A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis

Autor: Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Sara Wernig-Zorc, John P. Thomson, Roderick N. Carter, Marcus J. Lyall, Paul D. Walker, Alpesh Thakker, Richard R. Meehan, Gareth G. Lavery, Nicholas M. Morton, Christian Ludwig, Daniel A. Tennant, David C. Hay, Amanda J. Drake

Publikováno v: iScience, Vol 24, Iss 1, Pp 101931- (2021)

Summary: Nonalcoholic fatty liver disease (NAFLD) is currently the most prevalent form of liver disease worldwide. This term encompasses a spectrum of pathologies, from benign hepatic steatosis to non-alcoholic steatohepatitis, which have, to date, b

Externí odkaz: https://doaj.org/article/231ee5e1aa334f8c91d6ea963c63a1fc

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

Autor: David Story, Karen Burr, Roderick N. Carter, Arpan R Mehta, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Colin Smith, Jenna M. Gregory, Giles E. Hardingham, Nicholas M. Morton, Don J. Mahad, Owen Dando, Karina McDade, Jyoti Nanda

Publikováno v: Mehta, A R, Gregory, J M, Dando, O, Carter, R N, Burr, K, Nanda, J, Story, D, Mcdade, K, Smith, C, Morton, N M, Mahad, D J, Hardingham, G E, Chandran, S & Selvaraj, B T 2021, ' Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis ', Acta Neuropathologica . https://doi.org/10.1007/s00401-020-02252-5
Acta Neuropathologica

Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbc73ad975fbf9d387a95cbaa104da6
https://doi.org/10.1007/s00401-020-02252-5