Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Roderick J. Tan"'
Publikováno v:
Physiological Reports, Vol 12, Iss 5, Pp n/a-n/a (2024)
Abstract The role of NRF2 in kidney biology has received considerable interest over the past decade. NRF2 transcriptionally controls genes responsible for cellular protection against oxidative and electrophilic stress and has anti‐inflammatory func
Externí odkaz:
https://doaj.org/article/9236624e902b499bbcd18c0c7b6c2726
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4987 (2024)
Investigating the role of podocytes in proteinuric disease is imperative to address the increasing global burden of chronic kidney disease (CKD). Studies strongly implicate increased levels of monocyte chemoattractant protein-1 (MCP-1/CCL2) in protei
Externí odkaz:
https://doaj.org/article/ed7527a16a704d5f8392f40357fc2aa8
Autor:
Corry D. Bondi, Brittney M. Rush, Hannah L. Hartman, Jiaxuan Wang, Mohammad M. Al-Bataineh, Rebecca P. Hughey, Roderick J. Tan
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1810 (2022)
Acute kidney injury (AKI) is a rapid decline in renal function and can occur after ischemia/reperfusion injury (IRI) to the tubular epithelia. The nuclear factor erythroid-2-related factor 2 (NRF2) pathway protects against AKI and AKI-to-chronic kidn
Externí odkaz:
https://doaj.org/article/4cb02811a4ee47ee935911835864e619
Autor:
Katherine E. Shipman, Catherine J. Baty, Kimberly R. Long, Youssef Rbaibi, Isabella A. Cowan, Mona Gerges, Allison L. Marciszyn, Ossama B. Kashlan, Roderick J. Tan, Aurélie Edwards, Ora A. Weisz
Publikováno v:
Journal of the American Society of Nephrology. 34:619-640
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a69e770726ecbe1adceb2b8f0cdb8f01
https://doi.org/10.1681/asn.0000000000000084
https://doi.org/10.1681/asn.0000000000000084
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 10914 (2021)
Acute kidney injury due to renal ischemia-reperfusion injury (IRI) may lead to chronic or end stage kidney disease. A greater understanding of the cellular mechanisms underlying IRI are required to develop therapeutic options aimed at limiting or rev
Externí odkaz:
https://doaj.org/article/aa44700a1cc94cbaae1d3026b7042ad3
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 960 (2020)
Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation. MMP-7 i
Externí odkaz:
https://doaj.org/article/2598381de7dc43168bfa2f1652b425b2
Autor:
Kritika Ramani, Roderick J. Tan, Dong Zhou, Bianca M. Coleman, Chetan V. Jawale, Youhua Liu, Partha S. Biswas
Publikováno v:
Mediators of Inflammation, Vol 2018 (2018)
Chronic inflammation has an important role in the development and progression of most fibrotic diseases, for which no effective treatments exist. Tubulointerstitial fibrosis (TF) is characterized by irreversible deposition of fibrous tissue in chroni
Externí odkaz:
https://doaj.org/article/58de8874a66a46b7af5815fb31f5cff1
Autor:
Roderick J. Tan
Publikováno v:
Kidney International. 101:18-20
The effect of spaceflight on kidney function requires additional study. The nuclear factor erythroid 2-related factor 2 knockout mouse became the first genetically engineered strain sent into orbit and to return to earth alive. In this issue, Suzuki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99137f5be6ea7aeda4a215c896c77d7
https://doi.org/10.1016/j.kint.2021.11.002
https://doi.org/10.1016/j.kint.2021.11.002
Autor:
Sean D. Stocker, Corry D. Bondi, Sarah A. Small, Donna B. Stolz, Thomas W. Kensler, Soma Jobbagy, Sheldon I. Bastacky, Dionysios V. Chartoumpekis, Kacie M. Barry, Roderick J. Tan, Jason Ong, Brittney M. Rush
Publikováno v:
Kidney International. 99:102-116
The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway upregulates key cellular defenses. Clinical trials are utilizing pharmacologic Nrf2 inducers such as bardoxolone methyl to treat chronic kidney disease, but Nrf2 activation has been linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9af679940310be2dfa0c606293ede2
https://doi.org/10.1016/j.kint.2020.07.036
https://doi.org/10.1016/j.kint.2020.07.036
Publikováno v:
Kidney Int
Acute kidney injury (AKI) is a risk factor for the development of chronic kidney disease (CKD). One mechanism for this phenomenon is renal microvascular rarefaction and subsequent chronic impairment in perfusion. However, diagnostic tools to monitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde84df0f6f2ef932e6e8c2fc4582682
https://doi.org/10.1016/j.kint.2020.02.011
https://doi.org/10.1016/j.kint.2020.02.011