A phase 1/2 study of thiotepa-based immunochemotherapy in relapsed/refractory primary CNS lymphoma: the TIER trial

Autor: Kim Linton, Sridhar Chaganti, Kate Cwynarski, Josh Wright, Dominic Culligan, Roderick J. Johnson, Stefanie Thust, Ayesha S. Ali, Louise Hopkins, Aimee Jackson, Jeffery Smith, Andrew Davies, Andrés J.M. Ferreri, Shireen Kassam, Christopher P. Fox, Catherine Thomas, Ian Chau, David J. Lewis, Graham P. Collins, Nicolas Martinez-Calle, Dorothee P. Auer, Graham McIlroy

Publikováno v: Fox, C P, Ali, A S, McIlroy, G, Thust, S, Martinez-Calle, N, Jackson, A E, Hopkins, L M, Thomas, C M, Kassam, S, Wright, J, Chaganti, S, Smith, J, Chau, I, Culligan, D, Linton, K M, Collins, G P, Ferreri, A J M, Lewis, D, Davies, A J, Johnson, R, Auer, D P & Cwynarski, K 2021, ' A phase 1/2 study of thiotepa-based immunochemotherapy in relapsed/refractory primary CNS lymphoma : the TIER trial ', Blood Advances, vol. 5, no. 20, pp. 4073-4082 . https://doi.org/10.1182/bloodadvances.2021004779

Relapsed or refractory primary central nervous system lymphoma (rrPCNSL) confers a poor prognosis with no accepted standard of care. Very few prospective studies have been conducted in this patient group. This study was a multicenter phase 1/2 study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c35e4fab9d3adf204d37ff5cda856
https://doi.org/10.1182/bloodadvances.2021004779

Thalidomide maintenance following high-dose therapy in multiple myeloma: a UK myeloma forum phase 2 study

Autor: Roderick J. Johnson, John A. Snowden, Andy C. Rawstron, Kim Cocks, Graham Jackson, Sylvia Feyler

Publikováno v: British Journal of Haematology. 139:429-433

Summary Thalidomide maintenance has unresolved issues regarding dosage and toxicity. We evaluated this in five dose cohorts in 100 patients. At a median follow-up of 32·3 months, 23 patients had stopped thalidomide for disease progression, 54 for si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b96ed69830994ff5ec4b43b34d066d01
https://doi.org/10.1111/j.1365-2141.2007.06817.x

Analysis of CD34+ cell subsets in stem cell harvests can more reliably predict rapidity and durability of engraftment than total CD34+ cell dose, but steady state levels do not correlate with bone marrow reserve

Autor: Anne English, Guy Pratt, G. M. Smith, Roderick J. Johnson, Andrew Jack, Andy C. Rawstron, Gareth J. Morgan

Publikováno v: British Journal of Haematology. 114:937-943

In peripheral blood stem cell transplantation (PBSCT), the number of CD34+ cells transplanted has been shown to correlate well with both rapidity and durability of engraftment. However, it is clear that engraftment does not necessarily correlate with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c9f21577812916689dad174397a52f
https://doi.org/10.1046/j.1365-2141.2001.03027.x

Circulating Primitive Stem Cells in Paroxysmal Nocturnal Hemoglobinuria (PNH) Are Predominantly Normal in Phenotype But Granulocyte Colony-Stimulating Factor Treatment Mobilizes Mainly PNH Stem Cells

Autor: Steve Richards, Roderick J. Johnson, Gareth J. Morgan, Peter Hillmen, Sheila J.M. O’Connor, Andy C. Rawstron, Derek Norfolk

Publikováno v: Blood. 91:4504-4508

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia resulting from a somatic mutation in a hemopoietic stem cell. In most cases of hemolytic PNH, the majority of the marrow cells are derived from the PNH clone. Recent evidence h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49065cad54d56495bb2402a859026c92
https://doi.org/10.1182/blood.v91.12.4504

Circulating plasma cells in multiple myeloma: characterization and correlation with disease stage

Autor: Richard A. Jones, Faith E. Davies, Andy C. Rawstron, Roger G. Owen, Roderick J. Johnson, G. M. Smith, Stephen J. Richards, J. A. Child, Andrew Jack, Paul Evans, Gareth J. Morgan

Publikováno v: British Journal of Haematology. 97:46-55

The aim of this study was to develop a flow cytometric test to quantitate low levels of circulating myeloma plasma cells, and to determine the relationship of these cells with disease stage. Cells were characterized using five-parameter flow cytometr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51454289616ebc0117158fde8ade7562
https://doi.org/10.1046/j.1365-2141.1997.72653.x