Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Roderick A. F. MacLeod"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 32 (2023)
T-box genes encode transcription factors, which control developmental processes and promote cancer if deregulated. Recently, we described the lymphoid TBX-code, which collates T-box gene activities in normal lymphopoiesis, enabling identification of
Externí odkaz:
https://doaj.org/article/8f0318ec27e64a5eac62b311274f0a50
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1758 (2023)
BCL2, BCL6 and MYC are major oncogenes in B-cell lymphoma. Their aberrant activation frequently occurs via chromosomal translocations which juxtapose light or heavy chain immunoglobulin (IG) genes to BCL2 and MYC or fuse diverse partner genes with BC
Externí odkaz:
https://doaj.org/article/1cc3952e69e843bea82777582badeeab
Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma
Autor:
Stefan Nagel, Claudia Pommerenke, Hilmar Quentmeier, Corinna Meyer, Maren Kaufmann, Roderick A. F. MacLeod
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2038 (2022)
Cutaneous T-cell lymphoma (CTCL) is a severe lymphoid malignancy with a worse prognosis lacking curative treatment regimens. Several gene mutations and deregulated pathways, including NFkB signaling, have been implicated in its pathogenesis. Accordin
Externí odkaz:
https://doaj.org/article/27b1710692744292a7cc0ec82ae457a5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3192 (2022)
Homeobox genes encode transcription factors that control basic developmental decisions. Knowledge of their hematopoietic activities casts light on normal and malignant immune cell development. Recently, we constructed the so-called lymphoid TALE-code
Externí odkaz:
https://doaj.org/article/42d5d0cbbb2b406894b77563d0f28512
Autor:
Chao Ding, Su-Ning Chen, Roderick A. F. Macleod, Hans G. Drexler, Stefan Nagel, De-Pei Wu, Ai-Ning Sun, Hai-Ping Dai
Publikováno v:
Upsala Journal of Medical Sciences, Vol 123, Iss 1, Pp 19-27 (2018)
Background: Emerging evidence has revealed that miRNAs can function as oncogenes or tumor suppressor genes in leukemia. The ectopic expression of miR-130a has been reported in chronic leukemia, but our understanding of the biological implications of
Externí odkaz:
https://doaj.org/article/d9a61acf99c746f9aab67c61241a5722
NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate Megakaryocytic-Erythroid Cell Differentiation in AML
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11434 (2021)
NKL homeobox genes encode transcription factors that impact normal development and hematopoietic malignancies if deregulated. Recently, we established an NKL-code that describes the physiological expression pattern of eleven NKL homeobox genes in the
Externí odkaz:
https://doaj.org/article/4f2aa99bdbf6454eb228c565188ad745
Autor:
Stefan Ehrentraut, Stefan Nagel, Claudia Pommerenke, Wilhelm G. Dirks, Hilmar Quentmeier, Maren Kaufmann, Corinna Meyer, Margarete Zaborski, Robert Geffers, Hiroshi Fujiwara, Hans G. Drexler, Roderick A. F. MacLeod
Publikováno v:
Haematologica, Vol 102, Iss 9 (2017)
Externí odkaz:
https://doaj.org/article/16cc3a1ae074490ca864607c33efa9ef
Autor:
Lili Wu, Yang Xu, Qian Wang, Changgeng Ruan, Hans G. Drexler, Depei Wu, Roderick A. F. MacLeod, Suning Chen
Publikováno v:
Haematologica, Vol 100, Iss 6 (2015)
Externí odkaz:
https://doaj.org/article/307f0f2c8cd24b4bb1ccddd8a76fafc3
Autor:
Stefan Nagel, Stefan Ehrentraut, Jürgen Tomasch, Hilmar Quentmeier, Corinna Meyer, Maren Kaufmann, Hans G. Drexler, Roderick A. F. MacLeod
Publikováno v:
PLoS ONE, Vol 8, Iss 6 (2013)
Externí odkaz:
https://doaj.org/article/57e82939ac3943ceb3f468fe34a21762
Autor:
Lingzhi Yan, Nana Ping, Mingqing Zhu, Aining Sun, Yongquan Xue, Changgeng Ruan, Hans G. Drexler, Roderick A. F. MacLeod, Depei Wu, Suning Chen
Publikováno v:
Haematologica, Vol 97, Iss 11 (2012)
Among 4,780 consecutive adult acute lymphoblastic/myeloblastic leukemia patients, we identified 117 (2.4%) patients with mixed-phenotype acute leukemia fulfilling WHO 2008 criteria; these were classified as: Blymphoid+ myeloid (n=64), T-lymphoid+myel
Externí odkaz:
https://doaj.org/article/5a6409a5afdc4cae96754f22dfe2d86c