Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Roderick A. Barke"'
Autor:
Alice Chanakira, Devika Kir, Roderick A Barke, Steve M Santilli, Sundaram Ramakrishnan, Sabita Roy
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138587 (2015)
Intimal hyperplasia (IH) is a clinical concern leading to failure of up to 50% of vein grafts and 10% of arterial grafts after 10 years with no known current treatment. Recent studies have shown that hypoxia differentially regulates proliferation of
Externí odkaz:
https://doaj.org/article/59d31040f3394efdaf37b56b28791b60
Autor:
Jingjing Meng, Haidong Yu, Jing Ma, Jinghua Wang, Santanu Banerjee, Rick Charboneau, Roderick A Barke, Sabita Roy
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54040 (2013)
Opiates are among the most prescribed drugs for pain management. However, morphine use or abuse results in significant gut bacterial translocation and predisposes patients to serious infections with gut origin. The mechanism underlying this defect is
Externí odkaz:
https://doaj.org/article/56f75733eb584cd790e2410f436f5063
Publikováno v:
Nutrition and Gene Expression ISBN: 9781351075114
Nutrition and Gene Expression
Nutrition and Gene Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c2282170dada709b30dc2d861bd5915
https://doi.org/10.1201/9781351075114-14
https://doi.org/10.1201/9781351075114-14
Autor:
Steven M. Santilli, Alice Chanakira, Roderick A. Barke, Sabita Roy, Richard Charboneau, Raini Dutta
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 302:H1173-H1184
Despite intensive research studies, theories have yet to focus on the contribution of hypoxia to patency differences observed clinically between arterial vs. venous grafts. This study investigates the differential hypoxic response of smooth muscle ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5a99b6c46810a06733e5ca6cc391da
https://doi.org/10.1152/ajpheart.00411.2011
https://doi.org/10.1152/ajpheart.00411.2011
Publikováno v:
Archivum Immunologiae et Therapiae Experimentalis. 56:299-309
The first line of defense against invading bacteria is provided by the innate immune system. Morphine and other opiates can immediately disrupt the body's first line of defense against harmful external bacteria. Opiate, for example morphine, abuse de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ae0f1d0ad4432c19e358b957e78276
https://doi.org/10.1007/s00005-008-0035-0
https://doi.org/10.1007/s00005-008-0035-0
Autor:
Jinghua Wang, Jana Ninkovic, Roderick A. Barke, Richard Charboneau, Sabita Roy, Anitha Krishnan, Jennifer Kelschenbach
Publikováno v:
The Journal of Immunology. 180:3670-3679
There are very few studies that examine the effects that morphine withdrawal has on immune functioning, and of these even fewer describe the mechanisms by which withdrawal brings about these changes. Our previous work demonstrated that morphine withd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc24679ba53e454973c958cc5f01820
https://doi.org/10.4049/jimmunol.180.6.3670
https://doi.org/10.4049/jimmunol.180.6.3670
Publikováno v:
Journal of Biological Chemistry. 282:7164-7171
Chronic morphine inhibits interleukin-2 (IL-2) at both the transcriptional and protein synthesis levels. The molecular mechanisms by which morphine decreases IL-2 are not fully understood. The production of IL-2 is tightly regulated by several transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27b775d37c89a7829fee42135cf7ef0
https://doi.org/10.1074/jbc.m604367200
https://doi.org/10.1074/jbc.m604367200
Autor:
Devika Kir, Steve Santilli, Sabita Roy, Sundaram Ramakrishnan, Alice Chanakira, Roderick A. Barke
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0138587 (2015)
PLoS ONE, Vol 10, Iss 9, p e0138587 (2015)
Objective Intimal hyperplasia (IH) is a clinical concern leading to failure of up to 50% of vein grafts and 10% of arterial grafts after 10 years with no known current treatment. Recent studies have shown that hypoxia differentially regulates prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eea645f50ee379863531209b806ea9b
https://pubmed.ncbi.nlm.nih.gov/26381529
https://pubmed.ncbi.nlm.nih.gov/26381529
Publikováno v:
The Journal of Immunology. 175:6361-6367
Impaired host defense mechanisms after major operative procedures and trauma are recognized as important factors in the development of infectious complication. Trauma is associated with impaired cellular immunity and CD4+ T cell Th2 differentiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb147b6abaf5ef5882073ae4efd5bba9
https://doi.org/10.4049/jimmunol.175.10.6361
https://doi.org/10.4049/jimmunol.175.10.6361
Publikováno v:
The Journal of Immunology. 175:2655-2665
The consequences that drug withdrawal has on immune functioning has only recently been appreciated; however, given the wide variety of use and abuse of opiate analgesics, understanding the decrements to immune function that withdrawal from these drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926f785709e0903576b393a6d45af6bd
https://doi.org/10.4049/jimmunol.175.4.2655
https://doi.org/10.4049/jimmunol.175.4.2655