Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Roderich D. Süssmuth"'
Autor:
Maria Maares, Alessia Haupt, Christoph Schüßler, Marcel Kulike-Koczula, Julian Hackler, Claudia Keil, Isabelle Mohr, Lutz Schomburg, Roderich D. Süssmuth, Hans Zischka, Uta Merle, Hajo Haase
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/41fdd47f95824117afb8022bfb2e4bef
Autor:
Maria Maares, Alessia Haupt, Christoph Schüßler, Marcel Kulike-Koczula, Julian Hackler, Claudia Keil, Isabelle Mohr, Lutz Schomburg, Roderich D. Süssmuth, Hans Zischka, Uta Merle, Hajo Haase
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Labile copper(II) ions (Cu2+) in serum are considered to be readily available for cellular uptake and to constitute the biologically active Cu2+ species in the blood. It might also be suitable to reflect copper dyshomeostasis during diseases
Externí odkaz:
https://doaj.org/article/d7c0fb97d3734d86addb7fa041f0febc
Autor:
Guiyang Yao, Simone Kosol, Marius T. Wenz, Elisabeth Irran, Bettina G. Keller, Oliver Trapp, Roderich D. Süssmuth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The occurrence of isomers of the bicyclic octapeptide α-amanitin, which presents a macrolactam with a tryptathionine cross-link forming a handle, has been reported under the term of atropoisomers. Here, the authors synthesize its analogs and analyse
Externí odkaz:
https://doaj.org/article/ffa6050476a7482bbc3dca488bc7c362
Autor:
Tam Dang, Bernhard Loll, Sebastian Müller, Ranko Skobalj, Julia Ebeling, Timur Bulatov, Sebastian Gensel, Josefine Göbel, Markus C. Wahl, Elke Genersch, Andi Mainz, Roderich D. Süssmuth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The authors show that the N-acetyltransferase PamZ acts as a self-resistance factor disabling the antibacterial paenilamicin that is produced by the honey bee larvae pathogen Paenibacillus larvae.
Externí odkaz:
https://doaj.org/article/efd0e34fbaa048d5bbc9b3660ecfcfae
Autor:
Ignazio Avella, Maik Damm, Inês Freitas, Wolfgang Wüster, Nahla Lucchini, Óscar Zuazo, Roderich D. Süssmuth, Fernando Martínez-Freiría
Publikováno v:
Toxins, Vol 15, Iss 6, p 371 (2023)
European vipers (genus Vipera) are medically important snakes displaying considerable venom variation, occurring at different levels in this group. The presence of intraspecific venom variation, however, remains understudied in several Vipera species
Externí odkaz:
https://doaj.org/article/333ae0a7ab8540b7ae21a8b9d4fc744f
Autor:
Oleksandr Yushchuk, Iryna Ostash, Eva Mösker, Iryna Vlasiuk, Maksym Deneka, Christian Rückert, Tobias Busche, Victor Fedorenko, Jörn Kalinowski, Roderich D. Süssmuth, Bohdan Ostash
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Actinobacteria are among the most prolific sources of medically and agriculturally important compounds, derived from their biosynthetic gene clusters (BGCs) for specialized (secondary) pathways of metabolism. Genomics witnesses that the majo
Externí odkaz:
https://doaj.org/article/057a7057442146c8ad1690394f59b75a
Autor:
Constanze Knebel, Roderich D. Süssmuth, Helen S. Hammer, Albert Braeuning, Philip Marx-Stoelting
Publikováno v:
Cells, Vol 11, Iss 20, p 3293 (2022)
Triazole fungicides such as propiconazole (Pi) or tebuconazole (Te) show hepatotoxicity in vivo, e.g., hypertrophy and vacuolization of liver cells following interaction with nuclear receptors such as PXR (pregnane-X-receptor) and CAR (constitutive a
Externí odkaz:
https://doaj.org/article/d949b29fe11a42e0ba78bcdc32af96ef
Publikováno v:
Applied Microbiology and Biotechnology. 107(5-6):1687-1696
Abstract The enzymatic machinery involved in the biosynthesis of lantibiotic is an untapped source of proteases with different specificities. Lanthipeptide biosynthesis requires proteolysis of specific target sequences by known proteases, which are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c5f8baec9ea3c650631c562c08ceb2
https://ciencia.ucp.pt/en/publications/e1e3307b-5c6d-42ef-be1e-973b3dac1cbb
https://ciencia.ucp.pt/en/publications/e1e3307b-5c6d-42ef-be1e-973b3dac1cbb
Autor:
Elizabeth Michalczyk, Kay Hommernick, Iraj Behroz, Marcel Kulike, Zuzanna Pakosz-Stępień, Lukasz Mazurek, Maria Seidel, Maria Kunert, Karine Santos, Holger von Moeller, Bernhard Loll, John B. Weston, Andi Mainz, Jonathan G. Heddle, Roderich D. Süssmuth, Dmitry Ghilarov
Publikováno v:
Nature Catalysis. 6:52-67
The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However, its mode of action is poorly understood. We determined a 2.6 Å resolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f6167c88a9b76782c22e90ef4bd332
https://doi.org/10.1038/s41929-022-00904-1
https://doi.org/10.1038/s41929-022-00904-1
Autor:
Simone Kosol, Lida Rostock, Jonas Barsig, Theresa Tabarelli, Kay Hommernick, Marcel Kulike, Tobias Eulberg, Maria Seidel, Iraj Behroz, Leonardo Kleebauer, Stefan Grätz, Andi Mainz, Roderich D. Süssmuth
Publikováno v:
Chemical Science. 14:5069-5078
Exploiting the transcription regulatory activity of the AlbA resistance protein enables the design of improved albicidin analogs that can overcome the resistance mechanism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0597cf08a6ceda40d4445a948c049ab4
https://doi.org/10.1039/d3sc00955f
https://doi.org/10.1039/d3sc00955f