Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Roderic G. Eckenhoff"'
Autor:
Diana M. Plasencia, Liam H. Rodgers, Alexys R. Knighton, Roderic G. Eckenhoff, E. Railey White
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Despite their frequent use across many clinical settings, general anesthetics are medications with lethal side effects and no reversal agents. A fluorinated analogue of propofol has previously been shown to antagonize propofol anesthesia in
Externí odkaz:
https://doaj.org/article/6bd5df7f850b443c9ff50b18cf911029
Autor:
Aboubacar Wague, Thomas T Joseph, Kellie A Woll, Weiming Bu, Kiran A Vaidya, Natarajan V Bhanu, Benjamin A Garcia, Crina M Nimigean, Roderic G Eckenhoff, Paul M Riegelhaupt
Publikováno v:
eLife, Vol 9 (2020)
K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane to identify a V
Externí odkaz:
https://doaj.org/article/7e11d5322d4c418d8767b99777b16d8b
Autor:
Joseph G. Reiter, Bijan A. Niknam, David A. Wolk, Siddharth Jain, Mark D. Neuman, Roderic G. Eckenhoff, Jeffrey H. Silber, Alexander S. Hill, Sean Hashemi, Dylan S. Small, Paul R. Rosenbaum, Lee A. Fleisher
Publikováno v:
Ann Surg
OBJECTIVE: To determine if surgery and anesthesia in the elderly may promote Alzheimer’s Disease and Related Dementias (ADRD). BACKGROUND: There is a substantial conflicting literature concerning the hypothesis that surgery and anesthesia promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec0a4dbb128f29330734211866adf8c
https://pubmed.ncbi.nlm.nih.gov/33214467
https://pubmed.ncbi.nlm.nih.gov/33214467
Autor:
Andrew R. McKinstry-Wu, Andrzej Z. Wasilczuk, William P. Dailey, Roderic G. Eckenhoff, Max B. Kelz
Publikováno v:
The Journal of Neuroscience. 43:2338-2348
Photoaffinity ligands are best known as tools used to identify the specific binding sites of drugs to their molecular targets. However, photoaffinity ligands have the potential to further define critical neuroanatomic targets of drug action. In the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eeabb00f96dbaf20c8b591ada6b2f8c
https://doi.org/10.1523/jneurosci.1884-22.2023
https://doi.org/10.1523/jneurosci.1884-22.2023
Autor:
Hui Zha, Erika Matsunami, Nathan Blazon-Brown, Sophia Koutsogiannaki, Lifei Hou, Weiming Bu, Hasan Babazada, Kirsten C Odegard, Renyu Liu, Roderic G Eckenhoff, Koichi Yuki
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216163 (2019)
BackgroundPerioperative infections, particularly surgical site infections pose significant morbidity and mortality. Phagocytosis is a critical step for microbial eradication. We examined the effect of commonly used anesthetics on macrophage phagocyto
Externí odkaz:
https://doaj.org/article/34fe544a16154388aee9f070d1901ec1
Autor:
Sophia Koutsogiannaki, Weiming Bu, Wiriya Maisat, Mariel Manzor, Zhikuan Zhang, Umeharu Ohto, Roderic G. Eckenhoff, Koichi Yuki
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(8)
Sedatives/anesthetics are important medical tools to facilitate medical care and increase patients' comfort. Increasingly, there is recognition that sedatives/anesthetics can modulate immune functions. Toll-like receptors (TLRs) are major pattern rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8f92545bab0194b03c99cc033cf0d9
https://pubmed.ncbi.nlm.nih.gov/35899460
https://pubmed.ncbi.nlm.nih.gov/35899460
Autor:
Lioudmila Zoubak, Roderic G. Eckenhoff, Weiming Bu, Grace Brannigan, Alexei Yeliseev, Thomas T. Joseph, Renyu Liu, Wenzhen Lin
Publikováno v:
ACS Chemical Neuroscience
Ketamine is an anesthetic, analgesic, and antidepressant whose secondary metabolite (2R,6R)-hydroxynorketamine (HNK) has N-methyl-d-aspartate-receptor-independent antidepressant activity in a rodent model. In humans, naltrexone attenuates its antidep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2de4cdd2ff25108e6e0e12f1cb0c2ee
https://doi.org/10.1021/acschemneuro.0c00741
https://doi.org/10.1021/acschemneuro.0c00741
Autor:
Umeharu Ohto, Roderic G. Eckenhoff, Sophia Koutsogiannaki, Miho Shibamura-Fujiogi, Lifei Hou, Koichi Yuki, H. Ishida, Weiming Bu
Publikováno v:
FASEB J
Toll like receptors (TLRs) are critical receptors to respond to danger signals, and their functions are relevant in the perioperative period. We previously reported that volatile anesthetics directly bound to TLR2 and TLR4 and attenuated their functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1efac72f224576206b48728f8553c94
https://doi.org/10.1096/fj.202000791rr
https://doi.org/10.1096/fj.202000791rr
Publikováno v:
British Journal of Anaesthesia. 125:232-235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::687458c31f4083af71b8424d0cec66fa
https://doi.org/10.1016/j.bja.2020.06.010
https://doi.org/10.1016/j.bja.2020.06.010
Publikováno v:
Biochem Biophys Res Commun
Propofol is a clinically important intravenous anesthetic. We previously reported that it directly inhibited 5-lipoxygenase (5-LOX), a key enzyme for leukotriene biosynthesis. Because the hydroxyl group in propofol (propofol 1-hydroxyl) is critical f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a4beeda3e840d762d2aaed4311e2ae
https://doi.org/10.1016/j.bbrc.2020.03.037
https://doi.org/10.1016/j.bbrc.2020.03.037