Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Roded S"'
Autor:
Ron Sheinin, Koren Salomon, Eilam Yeini, Shai Dulberg, Ayelet Kaminitz, Ronit Satchi-Fainaro, Roded Sharan, Asaf Madi
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Cell-cell crosstalk involves simultaneous interactions of multiple receptors and ligands, followed by downstream signaling cascades working through receptors converging at dominant transcription factors, which then integrate and propagate mu
Externí odkaz:
https://doaj.org/article/475861597828497a890d2c699e017e4a
Akademický článek
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Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Autism spectrum disorder (ASD) is a highly heritable complex disease that affects 1% of the population, yet its underlying molecular mechanisms are largely unknown. Here we study the problem of predicting causal genes for ASD by combining genome-scal
Externí odkaz:
https://doaj.org/article/67ed22f0018a422cb108584b2f8445f3
Autor:
Orit Uziel, Lian Lipshtein, Zinab Sarsor, Einat Beery, Shaked Bogen, Meir Lahav, Alon Regev, Vitali Kliminski, Roded Sharan, Asia Gervits, Lorenzo Federico Signorini, Shai Shimony, Pia Raanani, Uri Rozovski
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1381 (2024)
We hypothesized that via extracellular vesicles (EVs), chronic lymphocytic leukemia (CLL) cells turn endothelial cells into CLL-supportive cells. To test this, we treated vein-derived (HUVECs) and artery-derived (HAOECs) endothelial cells with EVs is
Externí odkaz:
https://doaj.org/article/bf3dc91a0aee44c485dd06f2df73b75f
Autor:
Daniela Likonen, Maria Pinchasi, Einat Beery, Zinab Sarsor, Lorenzo Federico Signorini, Asia Gervits, Roded Sharan, Meir Lahav, Pia Raanani, Orit Uziel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract It is now well accepted that cancer cells change their microenvironment from normal to tumor-supportive state to provide sustained tumor growth, metastasis and drug resistance. These processes are partially carried out by exosomes, nano-size
Externí odkaz:
https://doaj.org/article/5e9691ff950149638a68082902a91aaf
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1011195 (2023)
Mutational processes and their exposures in particular genomes are key to our understanding of how these genomes are shaped. However, current analyses assume that these processes are uniformly active across the genome without accounting for potential
Externí odkaz:
https://doaj.org/article/5559e5019ac74465b4dfb1ba35e822c6
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Mutational signatures are key to understanding the processes that shape cancer genomes, yet their analysis requires relatively rich whole-genome or whole-exome mutation data. Recently, orders-of-magnitude sparser gene-panel-sequencing data h
Externí odkaz:
https://doaj.org/article/1eee8e0e684b4c5797b96c3ffaa77b66
Autor:
Asia Gervits, Roded Sharan
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
Large scale cancer genomics data provide crucial information about the disease and reveal points of intervention. However, systematic data have been collected in specific cell lines and their collection is laborious and costly. Hence, there is a need
Externí odkaz:
https://doaj.org/article/54a38da3889d4ee98030c30c33042fb5
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The natural ends of the linear eukaryotic chromosomes are protected by telomeres, which also play an important role in aging and cancer development. Telomere length varies between species, but it is strictly controlled in all organisms. The process o
Externí odkaz:
https://doaj.org/article/f3f802ade01444e4acee2371f6a13420
Autor:
Barak Gross, Roded Sharan
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The coronavirus pandemic has revolutionized our world, with vaccination proving to be a key tool in fighting the disease. However, a major threat to this line of attack are variants that can evade the vaccine. Thus, a fundamental problem of growing i
Externí odkaz:
https://doaj.org/article/5a18e1ec506846c9b0fc0020fbf82356