Zobrazeno 1 - 10
of 740
pro vyhledávání: '"Roddy S"'
Autor:
Kimberly Veliz, Feng Shen, Olga Shestova, Maksim Shestov, Alexander Shestov, Sara Sleiman, Tyler Hansen, Roddy S. O’Connor, Saar Gill
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200819- (2024)
Cell surface molecules transiently upregulated on activated T cells can play a counter-regulatory role by inhibiting T cell function. Deletion or blockade of such immune checkpoint receptors has been investigated to improve the function of engineered
Externí odkaz:
https://doaj.org/article/0b70b3ce58f74dc8b9252276d9958819
Autor:
Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endo
Externí odkaz:
https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
Autor:
Saba Ghassemi, Francisco J. Martinez-Becerra, Alyssa M. Master, Sarah A. Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos García-Cañaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D. Rabinowitz, Michael C. Milone, Carl H. June, Roddy S. O’Connor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 595-606 (2020)
Effective chimeric antigen receptor (CAR)-T cell therapy is dependent on optimal cell culture methods conducive to the activation and expansion of T cells ex vivo, as well as infection with CAR. Media formulations used in CAR-T cell manufacturing hav
Externí odkaz:
https://doaj.org/article/3c8878a6387c4c229e27c84bfdffb1ba
Autor:
Fathima A. Mohamed, Govindarajan Thangavelu, Stephanie Y. Rhee, Peter T. Sage, Roddy S. O’Connor, Jeffrey C. Rathmell, Bruce R. Blazar
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by the development of graft-versus-host disease (GVHD). In GVHD, rigorous pre-conditioning regimen resets the immune landscape and inflammatory mili
Externí odkaz:
https://doaj.org/article/bfe4afcb6fa14c9e8bf1e70dbb2ca343
Autor:
Joseph S. Durgin, Fraser Henderson, MacLean P. Nasrallah, Suyash Mohan, Sumei Wang, Simon F. Lacey, Jan Joseph Melenhorst, Arati S. Desai, John Y. K. Lee, Marcela V. Maus, Carl H. June, Steven Brem, Roddy S. O’Connor, Zev Binder, Donald M. O’Rourke
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Autologous chimeric antigen receptor (CAR) T cells targeted to epidermal growth factor receptor variant III (CAR T-EGFRvIII) have been developed and administered experimentally to treat patients with IDH1 wildtype recurrent glioblastoma (rGBM) (NCT02
Externí odkaz:
https://doaj.org/article/28e7edd3d6b7457386c94ed075c82476
Autor:
Erika L. Varner, Sophie Trefely, David Bartee, Eliana von Krusenstiern, Luke Izzo, Carmen Bekeova, Roddy S. O'Connor, Erin L. Seifert, Kathryn E. Wellen, Jordan L. Meier, Nathaniel W. Snyder
Publikováno v:
Open Biology, Vol 10, Iss 9 (2020)
Lysine lactoylation is a recently described protein post-translational modification (PTM). However, the biochemical pathways responsible for this acylation remain unclear. Two metabolite-dependent mechanisms have been proposed: enzymatic histone lysi
Externí odkaz:
https://doaj.org/article/adfcecc3a8e9419db3b33858cefd038c
Autor:
Juan C. Garcia-Canaveras, David Heo, Sophie Trefely, John Leferovich, Chong Xu, Benjamin I. Philipson, Saba Ghassemi, Michael C. Milone, Edmund K. Moon, Nathaniel W. Snyder, Carl H. June, Joshua D. Rabinowitz, Roddy S. O’Connor
Publikováno v:
Cells, Vol 10, Iss 9, p 2334 (2021)
The metabolic milieu of solid tumors provides a barrier to chimeric antigen receptor (CAR) T-cell therapies. Excessive lactate or hypoxia suppresses T-cell growth, through mechanisms including NADH buildup and the depletion of oxidized metabolites. N
Externí odkaz:
https://doaj.org/article/50d53015c0884756be813e46c6a7e1ed
Publikováno v:
Antibodies, Vol 10, Iss 3, p 25 (2021)
T cell therapies, including CAR T cells, have proven more effective in hematologic malignancies than solid tumors, where the local metabolic environment is distinctly immunosuppressive. In particular, the acidic and hypoxic features of the tumor micr
Externí odkaz:
https://doaj.org/article/30ff430ed4d14840b63580bf93ba0d65
Autor:
Veliz, Kimberly, Shen, Feng, Shestova, Olga, Shestov, Maksim, Shestov, Alexander, Sleiman, Sara, Hansen, Tyler, O’Connor, Roddy S., Gill, Saar
Publikováno v:
In Molecular Therapy: Oncology 20 June 2024 32(2)
Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy
Autor:
Tang, Yan, Liu, Wei, Kadu, Siddhant, Johnson, Omar, Hasanali, Zainul S., Kelly, Andre, Shestov, Alexander, Pajarillo, Raymone, Greenblatt, Eli, Holmes, Matthew, Wang, Li-Ping, Shih, Natalie, O’Connor, Roddy S., Ruella, Marco, Garfall, Alfred L., Allman, David, Vogl, Dan T., Cohen, Adam, June, Carl H., Sheppard, Neil C.
Publikováno v:
In Blood 11 January 2024 143(2):139-151