Výsledky vyhledávání - "Rod Brian Jimenez"

Fully Automated Peptide Mapping Protocol for Multi-Attribute Method by Liquid Chromatography–Tandem Mass Spectroscopy with a High-Throughput Robotic Liquid Handling System

Autor: Ben Niu, Methal Albarghouthi, Chen Qian, Xiaoyu Chen, Jihong Wang, Rod Brian Jimenez

The multi-attribute method (MAM) based on liquid chromatography–tandem mass spectroscopy is emerging as a powerful tool to directly monitor multiple product quality attributes simultaneously. Preparation of samples for MAM, however, is labor intens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa232c9d0ec490a551aaa6c0f697fbba
https://doi.org/10.1101/2020.01.10.902338

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A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies

Autor: Arnita Barnes, Herren Wu, Hui Feng, Shu Zhang, Raghothama Chaerkady, Gargi Roy, Jie Zhu, Thomas D. Martin, Diane Hatton, Michael A. Bowen, Lina Li, Rod Brian Jimenez, Megan Rice, Marcello Marelli, Jihong Wang

Publikováno v: mAbs

The conserved glycosylation site Asn297 of a monoclonal antibody (mAb) can be decorated with a variety of sugars that can alter mAb pharmacokinetics and recruitment of effector proteins. Antibodies lacking the core fucose at Asn297 (afucosylated mAbs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6789460f1fa27218fc536523c94a86b
http://europepmc.org/articles/PMC5916560

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A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins

Autor: Mingyan Cao, Jihong Wang, Weichen Xu, Rod Brian Jimenez, Nitin Agarwal, Haibin Luo, Rachel Mowery, Xiangyang Wang, Irina Ramos

Publikováno v: mAbs

During manufacturing and storage process, therapeutic proteins are subject to various post-translational modifications (PTMs), such as isomerization, deamidation, oxidation, disulfide bond modifications and glycosylation. Certain PTMs may affect bioa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06164de2ae2559d8e66b85efe4918409
https://doi.org/10.1080/19420862.2017.1364326

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Fully automated peptide mapping multi-attribute method by liquid chromatography–mass spectrometry with robotic liquid handling system

Autor: Rod Brian Jimenez, Ben Niu, Methal Albarghouthi, Chen Qian, Jihong Wang

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 198:113988

The multi-attribute method (MAM) based on liquid chromatography (LC)-tandem mass spectrometry is emerging as a powerful tool to directly monitor multiple product quality attributes simultaneously. To better implement MAM, either for product character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60df30465c3c3052b8bb2c3da7d54fa6
https://doi.org/10.1016/j.jpba.2021.113988

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