Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Rod Bremner"'
Autor:
Arthur Aubry, Joel D. Pearson, Jason Charish, Tao Yu, Jeremy M. Sivak, Dimitris P. Xirodimas, Hervé Avet-Loiseau, Jill Corre, Philippe P. Monnier, Rod Bremner
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113711- (2024)
Externí odkaz:
https://doaj.org/article/e123ac04ad4e41e196e403a93c6013ec
Autor:
Arthur Aubry, Joel D. Pearson, Jason Charish, Tao Yu, Jeremy M. Sivak, Dimitris P. Xirodimas, Hervé Avet-Loiseau, Jill Corre, Philippe P. Monnier, Rod Bremner
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112925- (2023)
Summary: The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers. Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of non-CRL targets is unknown. Here, CRISPR screens map
Externí odkaz:
https://doaj.org/article/98133b06f2024ab69e0484aa57d6b411
Autor:
Layla Pires, Brian C. Wilson, Rod Bremner, Amanda Lang, Jeremie Larouche, Ryan McDonald, Joel D. Pearson, Daniel Trcka, Jeff Wrana, James Wu, Cari M. Whyne
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The lack of therapeutic options to fight Covid-19 has contributed to the current global pandemic. Despite the emergence of effective vaccines, development of broad-spectrum antiviral treatment remains a significant challenge, in which antimi
Externí odkaz:
https://doaj.org/article/7e404c800941409a9e0dacbf3796c276
Autor:
Yimeng Fan, Wenyue Chen, Ran Wei, Wei Qiang, Joel D. Pearson, Tao Yu, Rod Bremner, Danian Chen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The Pax6-α-Cre mouse line used in retinal studies actually contains four transgene insertion within gene clusters of olfactory and vomeronasal receptors, leading to expression in not just retinal, but also olfactory and vomeronasal sensory neurons.
Externí odkaz:
https://doaj.org/article/f321428e28b24f4799fff4221b78fcda
Autor:
Joel D. Pearson, Daniel Trcka, Suying Lu, Sharon J. Hyduk, Mark Jen, Marie-Ming Aynaud, J. Javier Hernández, Philippos Peidis, Miriam Barrios-Rodiles, Kin Chan, Jim Woodgett, Tony Mazzulli, Liliana Attisano, Laurence Pelletier, Myron I. Cybulsky, Jeffrey L. Wrana, Rod Bremner
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background Sensitive, rapid, and accessible diagnostics continue to be critical to track the COVID-19 pandemic caused by the SARS-CoV-2 virus. RT-qPCR is the gold standard test, and comparison of methodologies and reagents, utilizing patient
Externí odkaz:
https://doaj.org/article/550187229e544508bd7d16774946297a
Autor:
Marie-Ming Aynaud, J. Javier Hernandez, Seda Barutcu, Ulrich Braunschweig, Kin Chan, Joel D. Pearson, Daniel Trcka, Suzanna L. Prosser, Jaeyoun Kim, Miriam Barrios-Rodiles, Mark Jen, Siyuan Song, Jess Shen, Christine Bruce, Bryn Hazlett, Susan Poutanen, Liliana Attisano, Rod Bremner, Benjamin J. Blencowe, Tony Mazzulli, Hong Han, Laurence Pelletier, Jeffrey L. Wrana
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Wide-spread outbreaks of pathogens require high intensity testing to manage. Here, the authors present C19-SPAR-Seq, a scalable and automated platform to analyse tens of thousands of SARS-CoV-2 patient samples in a single run.
Externí odkaz:
https://doaj.org/article/ac044901fa7a4d629bfedd519a0399c2
Autor:
Evan Amalfitano, Margot Karlikow, Masoud Norouzi, Katariina Jaenes, Seray Cicek, Fahim Masum, Peivand Sadat Mousavi, Yuxiu Guo, Laura Tang, Andrew Sydor, Duo Ma, Joel D. Pearson, Daniel Trcka, Mathieu Pinette, Aruna Ambagala, Shawn Babiuk, Bradley Pickering, Jeff Wrana, Rod Bremner, Tony Mazzulli, David Sinton, John H. Brumell, Alexander A. Green, Keith Pardee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Getting synthetic biology circuit-based sensors into field applications is still a challenge. Here the authors combine a circuit sensor with a glucose meter for small analyte and nucleic acid detection.
Externí odkaz:
https://doaj.org/article/3cb9f77bab4e4f33b765a22e58579292
Autor:
Suying Lu, David Duplat, Paula Benitez-Bolivar, Cielo León, Stephany D. Villota, Eliana Veloz-Villavicencio, Valentina Arévalo, Katariina Jaenes, Yuxiu Guo, Seray Cicek, Lucas Robinson, Philippos Peidis, Joel D. Pearson, Jim Woodgett, Tony Mazzulli, Patricio Ponce, Silvia Restrepo, John M. González, Adriana Bernal, Marcela Guevara-Suarez, Keith Pardee, Varsovia E. Cevallos, Camila González, Rod Bremner
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Continued waves, new variants, and limited vaccine deployment mean that SARS-CoV-2 tests remain vital to constrain the coronavirus disease 2019 (COVID-19) pandemic. Affordable, point-of-care (PoC) tests allow rapid screening in non-medical settings.
Externí odkaz:
https://doaj.org/article/50e2b825f9a343fbbebdb699a1eed727
Autor:
Joel D. Pearson, Rod Bremner
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100870- (2021)
Summary: Ectopic/overexpression systems are important for studying protein function, but care must be taken to avoid artifacts due to excessively high levels of overexpression. To study the function of YAP/TAZ in YAP/TAZ-deficient (YAPoff) cancers, w
Externí odkaz:
https://doaj.org/article/fc659cccd8f54ee18784b7852f7d2ffc
Autor:
Joel D. Pearson, Rod Bremner
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 5 (2021)
The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro-
Externí odkaz:
https://doaj.org/article/2b3a41e9246742a988601396ee93d929