Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Rod Balhorn"'
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 1115-1116 (2024)
Externí odkaz:
https://doaj.org/article/765e184f2f96482ab106b64201efbf73
Publikováno v:
ACS Central Science, Vol 5, Iss 1, Pp 122-144 (2018)
Externí odkaz:
https://doaj.org/article/51df0b18cdec4cb3a0d228c75679a275
Autor:
Reem R Al Olaby, Laurence Cocquerel, Adam Zemla, Laure Saas, Jean Dubuisson, Jost Vielmetter, Joseph Marcotrigiano, Abdul Ghafoor Khan, Felipe Vences Catalan, Alexander L Perryman, Joel S Freundlich, Stefano Forli, Shoshana Levy, Rod Balhorn, Hassan M Azzazy
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111333 (2014)
Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for better drugs that are effective in treating a br
Externí odkaz:
https://doaj.org/article/8b68f68916394776b203292170c32fca
Publikováno v:
ACS Central Science, Vol 5, Iss 1, Pp 122-144 (2018)
ACS Central Science
ACS Central Science
Non-Hodgkin lymphoma is one of the most common types of cancer. Relapsed and refractory diseases are still common and remain significant challenges as the majority of these patients eventually succumb to the disease. Herein, we report a translatable
Autor:
J. Christopher States, Helen G. Tempest, Rod Balhorn, Rafael Oliva, Stephen A. Krawetz, Jovita Mezquita-Pla, Kenneth C. Kleene, Peter L. Davies
Publikováno v:
Systems Biology in Reproductive Medicine. 64:399-402
This issue of Systems Biology in Reproductive Medicine (SBiRM) is dedicated in honor of Dr. Gordon H. Dixon’s (25 March 1930 – 24 July 2016) many contributions to our understanding of how nuclear c...
Publikováno v:
Journal of drug targeting. 28(10)
Selective high-affinity ligands (SHALs) belong to a novel class of small-molecule cancer therapeutics that function as targeted prodrugs. SH7139, the most advanced of the SHAL drugs designed to bind to a unique β-subunit structural epitope located o
Autor:
Monique Cosman Balhorn, Rod Balhorn
Publikováno v:
Oncotarget
SH7139, the first of a series of selective high affinity ligand (SHAL) oncology drug candidates designed to target and bind to the HLA-DR proteins overexpressed by B-cell lymphomas, has demonstrated exceptional efficacy in the treatment of Burkitt ly
Autor:
Rod Balhorn, Monique Cosman Balhorn, Klaus Steger, Martin Bergmann, Stefanie Neuhauser, Hans-Christian Schuppe
Publikováno v:
Systems biology in reproductive medicine. 64(6)
The expression of protamines and the binding of these small arginine-rich proteins to DNA complete the process of spermatid chromatin reorganization and the global inactivation of the male's haploid genome that occurs during the final stages of sperm
Autor:
Klaus Steger, Rod Balhorn
Publikováno v:
Anatomia, histologia, embryologia. 47(4)
Protamines are nuclear proteins which are specifically expressed in haploid male germ cells. Their replacement of histones and binding to DNA is followed by chromatin hypercondensation that protects DNA from negative influences by environmental facto
Publikováno v:
Protein & Peptide Letters. 18:802-810
Single molecule studies of protamine-DNA interactions have characterized the kinetics of protamine binding to DNA and the morphology of the toroidal subunits that comprise sperm chromatin. The results provided by these studies are reviewed, the advan