Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Rod, Chalk"'
Autor:
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0293548 (2024)
RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. FCER1G is a component of Fc recept
Externí odkaz:
https://doaj.org/article/a694cd69ff044329bed258122700d8e8
Autor:
Gabriela Dias Noske, Yun Song, Rafaela Sachetto Fernandes, Rod Chalk, Haitem Elmassoudi, Lizbé Koekemoer, C. David Owen, Tarick J. El-Baba, Carol V. Robinson, The COVID Moonshot Consortium, Glaucius Oliva, Andre Schutzer Godoy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The Main protease of SARS-CoV-2 is key for viral replication, but its maturation process is still not completely understood. Here, the authors not only reveal unique details from the first step of maturation, but also demonstrate how different classe
Externí odkaz:
https://doaj.org/article/42ae45687cae484c842b30be8eac947b
Autor:
Rod Chalk, William E. P. Greenland, Tiago Moreira, Jesse Coker, Shubhashish M. M. Mukhopadhyay, Eleanor Williams, Charlotte Manning, Tina Bohstedt, Rama McCrorie, Alejandra Fernandez-Cid, Nicola A. Burgess-Brown
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Mapping multiple glycan species to the same peptide and location from shared retention time of glycopeptides with MS and HPLC, Chalk, Greenland et al. construct a detailed mass-retention time database for Spike protein glycopeptides. This allows any
Externí odkaz:
https://doaj.org/article/c526a34029cf4619809766a292866602
Autor:
D. Sean Froese, Jolanta Kopec, Elzbieta Rembeza, Gustavo Arruda Bezerra, Anselm Erich Oberholzer, Terttu Suormala, Seraina Lutz, Rod Chalk, Oktawia Borkowska, Matthias R. Baumgartner, Wyatt W. Yue
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The human enzyme MTHFR links the folate and methionine cycles, which are essential for the biosynthesis of nucleotides and proteins. Here, the authors present the crystal structure and biochemical analysis of human MTHFR, providing molecular insights
Externí odkaz:
https://doaj.org/article/81b79808dd01406c825d1806af1a047c
Autor:
Andre Schutzer Godoy, Aline Minalli Nakamura, Alice Douangamath, Yun Song, Gabriela Dias Noske, Victor Oliveira Gawriljuk, Rafaela Sachetto Fernandes, Humberto D. Muniz Pereira, Ketllyn Irene Zagato Oliveira, Daren Fearon, Alexandre Dias, Tobias Krojer, Michael Fairhead, Alisa Powell, Louise Dunnet, Jose Brandao-Neto, Rachael Skyner, Rod Chalk, Frank von Delft, Dávid Bajusz, Miklós Bege, Anikó Borbás, György Miklós Keserű, Glaucius Oliva
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The NSP15 endoribonuclease enzyme, known as NendoU, is highly conserved and plays a critical role in the ability of the virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa19458d20abf8b20e94d12cf6d7b5e8
https://doi.org/10.1101/2022.09.26.509485
https://doi.org/10.1101/2022.09.26.509485
Autor:
Gabriela Noske, Yun Song, Rafaela Fernandes, Rod Chalk, Haitem Elmassoudi, Lizbé Koekemoer, C David Owen, Glaucius Oliva, Andre Godoy
Mpro is the main protease of SARS-CoV-2. Its dimeric form is responsible for cleavage of the viral polyprotein at 11 sites, including its own N- and C-termini. Mpro self-cleavage is called maturation, and it is crucial for enzyme dimerization and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f31888799e7996c3908b1e5c7e54906
https://doi.org/10.21203/rs.3.rs-1918005/v1
https://doi.org/10.21203/rs.3.rs-1918005/v1
Fasting hyperglucagonemia is a key feature of type 2 diabetes (T2D), which leads to increased hepatic glucose production and exacerbates hyperglycemia. Preclinical studies have shown that low concentrations of sulfonylureas can partially restore appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a5eb2ae114ebd8d52ec9da20c90a10
https://ora.ox.ac.uk/objects/uuid:6dd21c9f-5192-4d50-8f10-9a081f910f6b
https://ora.ox.ac.uk/objects/uuid:6dd21c9f-5192-4d50-8f10-9a081f910f6b
The intracellular environment hosts a large number of cancer- and other disease-relevant human proteins. Targeting these with internalized antibodies would allow therapeutic modulation of hitherto undruggable pathways, such as those mediated by prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da600cf5aa319159e0ef01eb08b7e66
https://ora.ox.ac.uk/objects/uuid:f3c9a70f-2fd9-4b50-bd9f-c7b84afefd81
https://ora.ox.ac.uk/objects/uuid:f3c9a70f-2fd9-4b50-bd9f-c7b84afefd81
Autor:
William E. P. Greenland, Nicola A. Burgess-Brown, Tina Bohstedt, Eleanor Williams, Rod Chalk, Charlotte Manning, Rama McCrorie, Tiago Moreira, Alejandra Fernández-Cid, Jesse Coker, S.M.M. Mukhopadhyay
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
We describe an analytical method for the identification, mapping and relative quantitation of glycopeptides from SARS-CoV-2 Spike protein. The method may be executed using a LC-TOF mass spectrometer, requires no specialized knowledge of glycan analys
Autor:
Sarah Able, Martin R. Gill, Ole Tietz, Abirami Lakshminarayanan, Afaf H. El-Sagheer, Rachel Anderson, Tom Brown, Katherine A. Vallis, Michael G. Walker, Rod Chalk, Jim A. Thomas
Theranostic radionuclides that emit Auger electrons (AE) can generate highly localised DNA damage and the accompanying gamma ray emission can be used for single-photon emission computed tomography (SPECT) imaging. Mismatched DNA base pairs (mismatche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908a328f8e177ad675faf6c7ce6943a6
https://ora.ox.ac.uk/objects/uuid:d6feda20-7ffe-42bc-b3bf-4587ff07cdb0
https://ora.ox.ac.uk/objects/uuid:d6feda20-7ffe-42bc-b3bf-4587ff07cdb0