Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Rocky Lai"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected but ineffectively restrict bacterial replication. The distribution of M. tuberculosis among different cell types in the lung changes with the onset o
Externí odkaz:
https://doaj.org/article/93672e28da67482983cb58fa90209049
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Breakthrough findings in the clinical and preclinical development of tuberculosis (TB) vaccines have galvanized the field and suggest, for the first time since the development of bacille Calmette-Guérin (BCG), that a novel and protective TB
Externí odkaz:
https://doaj.org/article/d45165aae2494116803121eb594e0bb8
Autor:
Sam Afkhami, Michael R. D’Agostino, Maryam Vaseghi-Shanjani, Madeleine Lepard, Jack X. Yang, Rocky Lai, Margaret Wa Yan Choi, Alexis Chacon, Anna Zganiacz, Kees L. M. C. Franken, Hildegund C. Ertl, Tom H. M. Ottenhoff, Mangalakumari Jeyanathan, Amy Gillgrass, Zhou Xing
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract Viral-vectored vaccines are highly amenable for respiratory mucosal delivery as a means of inducing much-needed mucosal immunity at the point of pathogen entry. Unfortunately, current monovalent viral-vectored tuberculosis (TB) vaccine candi
Externí odkaz:
https://doaj.org/article/d2dc7116602d419c9248036c6fe44964
Autor:
Rocky Lai, Diana N. Gong, Travis Williams, Abiola F. Ogunsola, Kelly Cavallo, Cecilia S. Lindestam Arlehamn, Sarah Acolatse, Gillian L. Beamer, Martin T. Ferris, Christopher M. Sassetti, Douglas A. Lauffenburger, Samuel M. Behar
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Heterogeneity in human immune responses is difficult to model in standard laboratory mice. To understand how host variation affects Bacillus Calmette Guerin–induced (BCG-induced) immunity against Mycobacterium tuberculosis, we studied 24 unique col
Externí odkaz:
https://doaj.org/article/fa4dabc704214397b7fdfba0992f39f3
Autor:
Clare M. Smith, Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Richard E. Baker, Samuel M. Behar, Christopher M. Sassetti
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Host genetics plays an important role in determining the outcome of Mycobacterium tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains differ in their susceptibility to M. tuberculosis and that the CC042/Ge
Externí odkaz:
https://doaj.org/article/d4cab79506754b9ea4ff592ecc872668
Publikováno v:
European Respiratory Review, Vol 24, Iss 136, Pp 356-360 (2015)
Despite the use of bacille Calmette–Guérin (BCG) for almost a century, pulmonary tuberculosis (TB) continues to be a serious global health concern. Therefore, there has been a pressing need for the development of new booster vaccines to enhance ex
Externí odkaz:
https://doaj.org/article/995181bb8b0a4e7e9c7d65ecd4c4d81d
Autor:
Daniela Damjanovic, Amandeep Khera, Sam Afkhami, Rocky Lai, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131175 (2015)
Tuberculosis (TB) remains a global pandemic despite the use of Bacillus Calmette-Guérin (BCG) vaccine, partly because BCG fails to effectively control adult pulmonary TB. The introduction of novel boost vaccines such as the human Adenovirus 5-vector
Externí odkaz:
https://doaj.org/article/feabd3d1566a4f9f9dfade1b1dda14aa
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
Mycobacterium tuberculosis (M.tb), the causative bacterium of pulmonary tuberculosis (TB), is a serious global health concern. Central to M.tb effective immune avoidance is its ability to modulate the early innate inflammatory response and prevent th
Externí odkaz:
https://doaj.org/article/dccf3cd2ec4e4042a70288d58476fc23
Autor:
Rocky Lai, Diana Gong, Travis Williams, Abiola F. Ogunsola, Kelly Cavallo, Cecilia S. Lindestam Arlehamn, Sarah Acolatse, Gillian L. Beamer, Martin T. Ferris, Christopher M. Sassetti, Douglas A. Lauffenburger, Samuel M. Behar
SummaryThe heterogeneity of immune responses observed in humans is difficult to model in standard inbred laboratory mice. To capture the diversity inherent in mice and better understand how host variation affects BCG-induced immunity againstMycobacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eceeec70330a3ea5268cc3ee74c2f89a
https://doi.org/10.1101/2022.09.19.508548
https://doi.org/10.1101/2022.09.19.508548
Autor:
Sam Afkhami, Yushi Yao, Michael R. D’Agostino, Anna Zganiacz, Zhou Xing, Mangalakumari Jeyanathan, Rocky Lai, Maryam Vaseghi-Shanjani, Amandeep Khera
Publikováno v:
The Journal of Immunology. 205:2750-2762
Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis (TB), is responsible for millions of infections and deaths annually. Decades of TB vaccine development have focused on adaptive T cell immunity, whereas the importance of innat