Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rocky J. Barney"'
Autor:
Rocky J. Barney, Ashley M Kilcollins, Andrew J. Wiemer, Jin Li, M. Lei Geng, David F. Wiemer, Chia-Hung Christine Hsiao, Rebekah R. Shippy
Publikováno v:
ChemBioChem. 17:52-55
Cell-cleavable protecting groups often enhance cellular delivery of species that are charged at physiological pH. Although several phosphonate protecting groups have achieved clinical success, it remains difficult to use these prodrugs in live cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0910bd6fa05f91a346b60f12face8c3e
https://doi.org/10.1002/cbic.201500484
https://doi.org/10.1002/cbic.201500484
Autor:
Chia-Hung Christine Hsiao, Xiaochen Lin, Andrew J. Wiemer, Rocky J. Barney, Olga Vinogradova, Jin Li, David F. Wiemer, Rebekah R. Shippy
Publikováno v:
Chemistry & Biology. 21:945-954
SummaryPhosphoantigen-sensitive Vγ9Vδ2 T cells are important responders to infections and malignancy. However, the mechanisms by which phosphoantigens stimulate Vγ9Vδ2 T cells are unclear. Here, we synthesized phosphoantigen prodrugs and used the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c8820b3dc50b46b1069ca61ba2d522
https://doi.org/10.1016/j.chembiol.2014.06.006
https://doi.org/10.1016/j.chembiol.2014.06.006
Autor:
Chia-Hung Christine Hsiao, David F. Wiemer, Olga Vinogradova, Andrew J. Wiemer, Rebekah R. Shippy, Xiaochen Lin, Jin Li, Rocky J. Barney
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 190:751-753
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e10ff2d3a9b1fbc55832f110fc64e35a
https://doi.org/10.1080/10426507.2014.974099
https://doi.org/10.1080/10426507.2014.974099
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:7212-7220
Geminal bisphosphonates display varied biological activity depending on the nature of the substituents on the central carbon atom. For example, the nitrogenous bisphosphonates zoledronate and risedronate inhibit the enzyme farnesyl diphosphate syntha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0e84510dab30396ee79474d2271400
https://doi.org/10.1016/j.bmc.2010.08.036
https://doi.org/10.1016/j.bmc.2010.08.036
Autor:
Olga Vinogradova, Chia-Hung Christine Hsiao, Rebekah R. Shippy, Andrew J. Wiemer, Xiaochen Lin, David F. Wiemer, Rocky J. Barney, Jin Li
Publikováno v:
ChemInform. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f041a953d917bbdaf2d2c72f58e75bc
https://doi.org/10.1002/chin.201539270
https://doi.org/10.1002/chin.201539270
Publikováno v:
Tetrahedron Letters. 53:6682-6684
Several trialkyl and two triaryl phosphites have been tested for their reactivity in the zinc iodide mediated conversion of benzyl alcohol to the corresponding phosphonates. Most react smoothly to afford the desired phosphonate diesters, including hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9cca523fd123f9bd42d64fb0f93766
https://doi.org/10.1016/j.tetlet.2012.09.114
https://doi.org/10.1016/j.tetlet.2012.09.114
Publikováno v:
ChemInform. 44
The spectrum of phosphite substrates used also includes hindered and optically active ones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24a35b9b918e31c837ed75f4b980be8
https://doi.org/10.1002/chin.201314202
https://doi.org/10.1002/chin.201314202
Publikováno v:
ChemInform. 42
Benzyl phosphonate esters often serve as reagents in Horner−Wadsworth−Emmons reactions. In most cases, they can be prepared from benzylic alcohols via formation of the corresponding halide followed by an Arbuzov reaction. To identify a more direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63445662ca0417791a04455c8ae8b633
https://doi.org/10.1002/chin.201130193
https://doi.org/10.1002/chin.201130193
Benzyl phosphonate esters often serve as reagents in Horner-Wadsworth-Emmons reactions. In most cases, they can be prepared from benzylic alcohols via formation of the corresponding halide followed by an Arbuzov reaction. To identify a more direct sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbdd67277f21ba72f4dbca47f49e54b
https://europepmc.org/articles/PMC3204863/
https://europepmc.org/articles/PMC3204863/
Autor:
Larry W. Shull, David F. Wiemer, Rocky J. Barney, Andrew J. Wiemer, Raymond J. Hohl, Kimberly M. Lamb, Brian M. Wasko, Jose S. Yu
Publikováno v:
Bioorganicmedicinal chemistry. 16(7)
Nitrogenous bisphosphonate inhibitors of farnesyl disphosphate synthase have been used clinically for treatment of bone disease. Because many of their effects may be mediated by depletion of geranylgeranyl diphosphate, our group has sought compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217bb4c0a9010dfb4f76fd38f0977dbb
https://pubmed.ncbi.nlm.nih.gov/18308574
https://pubmed.ncbi.nlm.nih.gov/18308574