Zobrazeno 1 - 10
of 1 776
pro vyhledávání: '"Rockett, Ka"'
Autor:
Band, G, Leffler, EM, Jallow, M, Sisay-Joof, F, Ndila, CM, Macharia, AW, Hubbart, C, Jeffreys, AE, Rowlands, K, Nguyen, T, Gonçalves, S, Ariani, CV, Stalker, J, Pearson, RD, Amato, R, Drury, E, Sirugo, G, d'Alessandro, U, Bojang, KA, Marsh, K, Peshu, N, Saelens, JW, Diakité, M, Taylor, SM, Conway, DJ, Rockett, KA, Kwiatkowski, DP, Williams, TN
Publikováno v:
Nature. 602:106-111
Host genetic factors can confer resistance against malaria1, raising the question of whether this has led to evolutionary adaptation of parasite populations. Here we searched for association between candidate host and parasite genetic variants in 3,3
Autor:
Gilchrist, JJ, Kariuki, SN, Watson, JA, Band, G, Uyoga, S, Ndila, CM, Mturi, N, Mwarumba, S, Mohammed, S, Mosobo, M, Alasoo, K, Rockett, KA, Mentzer, AJ, Kwiatkowski, DP, Hill, AVS, Maitland, K, Scott, JAG, Williams, TN
Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12a6766bb51b546c99f298525a25403
http://hdl.handle.net/10044/1/98502
http://hdl.handle.net/10044/1/98502
Autor:
Opi DH; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Ndila CM; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Uyoga S; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Macharia AW; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Fennell C; Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Ochola LB; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Nyutu G; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Siddondo BR; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Ojal J; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Shebe M; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Awuondo KO; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Mturi N; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Peshu N; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Tsofa B; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya., Band G; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Maitland K; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.; Institute for Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, United Kingdom., Kwiatkowski DP; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Rockett KA; Wellcome Centre for Human Genetics, Oxford, United Kingdom., Williams TN; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.; Institute for Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, United Kingdom., Rowe JA; Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Publikováno v:
PLoS genetics [PLoS Genet] 2023 Sep 14; Vol. 19 (9), pp. e1010910. Date of Electronic Publication: 2023 Sep 14 (Print Publication: 2023).
Autor:
Uyoga, S, Watson, JA, Wanjiku, P, Rop, JC, Makale, J, Macharia, AW, Kariuki, SN, Nyutu, GM, Shebe, M, Mosobo, M, Mturi, N, Rockett, KA, Woodrow, CJ, Dondorp, AM, Maitland, K, White, NJ, Williams, TN
Publikováno v:
Nature communications, 13(1):3307. Nature Publishing Group
Severe falciparum malaria is a major cause of preventable child mortality in sub-Saharan Africa. The sequestration of parasitized erythrocytes in the microvasculature of vital organs is a central pathophysiological feature. The plasma concentration o
Autor:
Ndila, CM, Nyirongo, V, Macharia, AW, Jeffreys, AE, Rowlands, K, Hubbart, C, Busby, GBJ, Band, G, Harding, RM, Rockett, KA, Williams, TN, MalariaGEN Consortium
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
Background: The -α 3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any co
Autor:
Ndila, CM, Nyirongo, V, Macharia, AW, Jeffreys, AE, Rowlands, K, Hubbart, C, Busby, GBJ, Band, G, Harding, RM, Rockett, KA, Williams, TN
Background: The -α3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::9e048044c2dbc549c88a877f1b18b9bb
http://hdl.handle.net/10044/1/104846
http://hdl.handle.net/10044/1/104846
Autor:
Gilchrist JJ; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Auckland K; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Parks T; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Department of Infectious Diseases, Imperial College London, London, United Kingdom., Mentzer AJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Goldblatt L; Balliol College, Oxford, United Kingdom., Naranbhai V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Band G; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Rockett KA; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Toure OB; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Konate S; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Sissoko S; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Djimdé AA; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Thera MA; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Doumbo OK; Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Sow S; Center for Vaccine Development, Bamako, Mali., Floyd S; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom., Pönnighaus JM; Malawi Epidemiology and Intervention Research Unit (formerly Karonga Prevention Study), Chilumba, Malawi., Warndorff DK; Malawi Epidemiology and Intervention Research Unit (formerly Karonga Prevention Study), Chilumba, Malawi., Crampin AC; Malawi Epidemiology and Intervention Research Unit (formerly Karonga Prevention Study), Chilumba, Malawi., Fine PEM; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom., Fairfax BP; MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Hill AVS; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Jenner Institute, University of Oxford, Oxford, United Kingdom.
Publikováno v:
PLoS pathogens [PLoS Pathog] 2022 Sep 19; Vol. 18 (9), pp. e1010312. Date of Electronic Publication: 2022 Sep 19 (Print Publication: 2022).
Autor:
Gilchrist JJ; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Kariuki SN; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Watson JA; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Band G; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Uyoga S; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Ndila CM; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Mturi N; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Mwarumba S; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Mohammed S; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Mosobo M; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya., Alasoo K; Institute of Computer Science, University of Tartu, Tartu, Estonia., Rockett KA; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Mentzer AJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Kwiatkowski DP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Wellcome Sanger Institute, Cambridge, United Kingdom., Hill AVS; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; The Jenner Institute, University of Oxford, Oxford, United Kingdom., Maitland K; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.; Division of Medicine, Imperial College, London, United Kingdom., Scott JAG; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom., Williams TN; KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.; Institute for Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, United Kingdom.
Publikováno v:
ELife [Elife] 2022 Jul 22; Vol. 11. Date of Electronic Publication: 2022 Jul 22.
Autor:
Olaniyan, SA, Amodu, OK, Bakare, AA, Troye-Blomberg, M, Omotade, OO, Rockett, KA, Consortium, Malariagen
Publikováno v:
Acta Tropica. 161:62-67
Tumour necrosis factor (TNF) – α has been shown to play an important role in the pathogenesis of falciparum malaria. Two TNF promoter polymorphisms, TNF-308 and TNF-238 have been associated with differential activity and production of TNF. In orde
Autor:
Band G; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. gavin.band@well.ox.ac.uk.; Wellcome Sanger Institute, Hinxton, Cambridge, UK. gavin.band@well.ox.ac.uk.; Big Data Institute, Li Ka Shing Centre for Health and Information Discovery, University of Oxford, Oxford, UK. gavin.band@well.ox.ac.uk., Leffler EM; Wellcome Sanger Institute, Hinxton, Cambridge, UK.; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA., Jallow M; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.; Edward Francis Small Teaching Hospital (formerly Royal Victoria Teaching Hospital), Banjul, The Gambia., Sisay-Joof F; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Ndila CM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Macharia AW; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Hubbart C; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Jeffreys AE; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Rowlands K; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nguyen T; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Gonçalves S; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Ariani CV; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Stalker J; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Pearson RD; Wellcome Sanger Institute, Hinxton, Cambridge, UK.; Big Data Institute, Li Ka Shing Centre for Health and Information Discovery, University of Oxford, Oxford, UK., Amato R; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Drury E; Wellcome Sanger Institute, Hinxton, Cambridge, UK., Sirugo G; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.; Division of Translational Medicine and Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA., d'Alessandro U; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Bojang KA; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia., Marsh K; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Peshu N; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Saelens JW; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Diakité M; Malaria Research and Training Center, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali., Taylor SM; Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Duke Global Health Institute, Duke University, Durham, NC, USA., Conway DJ; Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Williams TN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Institute for Global Health Innovation, Department of Surgery and Cancer, Imperial College London, London, UK., Rockett KA; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. kirk.rockett@well.ox.ac.uk.; Wellcome Sanger Institute, Hinxton, Cambridge, UK. kirk.rockett@well.ox.ac.uk., Kwiatkowski DP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. dominic@sanger.ac.uk.; Wellcome Sanger Institute, Hinxton, Cambridge, UK. dominic@sanger.ac.uk.; Big Data Institute, Li Ka Shing Centre for Health and Information Discovery, University of Oxford, Oxford, UK. dominic@sanger.ac.uk.
Publikováno v:
Nature [Nature] 2022 Feb; Vol. 602 (7895), pp. 106-111. Date of Electronic Publication: 2021 Dec 09.