Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Rocio Sotillo"'
Autor:
Anchel de Jaime-Soguero, Janina Hattemer, Anja Bufe, Alexander Haas, Jeroen van den Berg, Vincent van Batenburg, Biswajit Das, Barbara di Marco, Stefania Androulaki, Nicolas Böhly, Jonathan J. M. Landry, Brigitte Schoell, Viviane S. Rosa, Laura Villacorta, Yagmur Baskan, Marleen Trapp, Vladimir Benes, Andrei Chabes, Marta Shahbazi, Anna Jauch, Ulrike Engel, Annarita Patrizi, Rocio Sotillo, Alexander van Oudenaarden, Josephine Bageritz, Julieta Alfonso, Holger Bastians, Sergio P. Acebrón
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Human development relies on the correct replication, maintenance and segregation of our genetic blueprints. How these processes are monitored across embryonic lineages, and why genomic mosaicism varies during development remain unknown. Usin
Externí odkaz:
https://doaj.org/article/02e8142c717c4f43bd91131e0cf9b945
Autor:
Alicia Alonso de la Vega, Nuri Alpay Temiz, Rafail Tasakis, Kalman Somogyi, Lorena Salgueiro, Eleni Zimmer, Maria Ramos, Alberto Diaz-Jimenez, Sara Chocarro, Mirian Fernández-Vaquero, Bojana Stefanovska, Eli Reuveni, Uri Ben-David, Albrecht Stenzinger, Tanja Poth, Mathias Heikenwälder, Nina Papavasiliou, Reuben S. Harris, Rocio Sotillo
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background RNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The cytosine deaminase APOBEC3B is implicated in tumor evolution through DNA mutation, but whet
Externí odkaz:
https://doaj.org/article/4370126016334153b5ad7b9bf80e0892
Autor:
Fan Pan, Sara Chocarro, Maria Ramos, Yuanyuan Chen, Alicia Alonso de la Vega, Kalman Somogyi, Rocio Sotillo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-17 (2023)
Abstract Tumor progression and evolution are frequently associated with chromosomal instability (CIN). Tumor cells often express high levels of the mitotic checkpoint protein MAD2, leading to mitotic arrest and cell death. However, some tumor cells a
Externí odkaz:
https://doaj.org/article/2a0c754eb2cc466ba280dc86cbb669e4
Autor:
Sridhar Kandala, Maria Ramos, Lena Voith von Voithenberg, Alberto Diaz-Jimenez, Sara Chocarro, Johanna Keding, Benedikt Brors, Charles D. Imbusch, Rocio Sotillo
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113266- (2023)
Summary: Chromosome instability (CIN) contributes to resistance to therapies and tumor evolution. Although natural killer (NK) cells can eliminate cells with complex karyotypes, high-CIN human tumors have an immunosuppressive phenotype. To understand
Externí odkaz:
https://doaj.org/article/478d76bd7d014ba4b60441bc8b5a3250
Autor:
Benjamin Raach, Nils Bundgaard, Marika J Haase, Jörn Starruß, Rocio Sotillo, Megan L Stanifer, Frederik Graw
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011356 (2023)
Human airway epithelium (HAE) represents the primary site of viral infection for SARS-CoV-2. Comprising different cell populations, a lot of research has been aimed at deciphering the major cell types and infection dynamics that determine disease pro
Externí odkaz:
https://doaj.org/article/04322daf9f3e44da9eeaa393bf6b4489
Autor:
Yuanyuan Chen, Reka Toth, Sara Chocarro, Dieter Weichenhan, Joschka Hey, Pavlo Lutsik, Stefan Sawall, Georgios T. Stathopoulos, Christoph Plass, Rocio Sotillo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Lung adenocarcinoma is a highly plastic tumour type. Here, the authors use single cell RNA sequencing to show that Club cells use regeneration mechanisms to develop tumours after an epigenetic switch towards an AT2-like phenotype shown by methylome a
Externí odkaz:
https://doaj.org/article/fe7cc9cdef0b40928506daf480b6be46
Publikováno v:
Immunity, Inflammation and Disease, Vol 8, Iss 2, Pp 181-187 (2020)
Abstract Introduction Alveolar macrophages (AMs) are critical in the development of lung adenocarcinoma driven by epidermal growth factor receptor (EGFR) mutations. Whether interstitial macrophages (IMs) are also involved in lung tumorigenesis is sti
Externí odkaz:
https://doaj.org/article/6684ba3d20a04ce1b7ffcf87ea57ecb5
Autor:
Lorena Salgueiro, Christopher Buccitelli, Konstantina Rowald, Kalman Somogyi, Sridhar Kandala, Jan O Korbel, Rocio Sotillo
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using
Externí odkaz:
https://doaj.org/article/225029ac68f7435d9344bd21f7538671
Publikováno v:
Cancers, Vol 13, Iss 23, p 6027 (2021)
Aneuploidy, an imbalance number of chromosomes, is frequently observed in lung cancer and inversely correlates with patient survival. Paradoxically, an aneuploid karyotype has detrimental consequences on cellular fitness, and it has been proposed tha
Externí odkaz:
https://doaj.org/article/0ee6f6bff3974e55a8f668dec510a176
Autor:
Magda Spella, Ioannis Lilis, Mario AA Pepe, Yuanyuan Chen, Maria Armaka, Anne-Sophie Lamort, Dimitra E Zazara, Fani Roumelioti, Malamati Vreka, Nikolaos I Kanellakis, Darcy E Wagner, Anastasios D Giannou, Vasileios Armenis, Kristina AM Arendt, Laura V Klotz, Dimitrios Toumpanakis, Vassiliki Karavana, Spyros G Zakynthinos, Ioanna Giopanou, Antonia Marazioti, Vassilis Aidinis, Rocio Sotillo, Georgios T Stathopoulos
Publikováno v:
eLife, Vol 8 (2019)
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epit
Externí odkaz:
https://doaj.org/article/9421923638cf48a683acda8f764cb505