Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Rocio Sancho"'
Autor:
Teodora Manea, Jessica Kristine Nelson, Cristina Maria Garrone, Karin Hansson, Ian Evans, Axel Behrens, Rocio Sancho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Understanding the factors and mechanisms involved in beta-cell development will guide therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) is the key transcription factor that marks endocrine progenit
Externí odkaz:
https://doaj.org/article/659513cc4feb44a297984081dccc3d55
Autor:
James Williams, Chloe Hurling, Sabrina Munir, Peter Harley, Carolina Barcellos Machado, Ana-Maria Cujba, Mario Alvarez-Fallas, Davide Danovi, Ivo Lieberam, Rocio Sancho, Philip Beales, Fiona M. Watt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Bardet-Biedl syndrome (BBS) is a ciliopathy with pleiotropic effects on multiple tissues, including the kidney. Here we have compared renal differentiation of iPS cells from healthy and BBS donors. High content image analysis of WT1-expressing kidney
Externí odkaz:
https://doaj.org/article/d171a7913adc46668842c8c82971940f
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101656- (2022)
Summary: Human induced pluripotent stem cells (hiPSCs) and organoids are important for modeling human development and disease in vitro. In this study, we describe a protocol to differentiate hiPSC toward pancreatic progenitor (PP) organoids and beta-
Externí odkaz:
https://doaj.org/article/6e78da5a9a6242bfaa92ef7748d07f91
Autor:
Joe M. Segal, Deniz Kent, Daniel J. Wesche, Soon Seng Ng, Maria Serra, Bénédicte Oulès, Gozde Kar, Guy Emerton, Samuel J. I. Blackford, Spyros Darmanis, Rosa Miquel, Tu Vinh Luong, Ryo Yamamoto, Andrew Bonham, Wayel Jassem, Nigel Heaton, Alessandra Vigilante, Aileen King, Rocio Sancho, Sarah Teichmann, Stephen R. Quake, Hiromitsu Nakauchi, S. Tamir Rashid
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of c
Externí odkaz:
https://doaj.org/article/6bbc0c0ed8f149fd9701e5f07676f1d3
Autor:
Rute M.M. Ferreira, Rocio Sancho, Hendrik A. Messal, Emma Nye, Bradley Spencer-Dene, Richard K. Stone, Gordon Stamp, Ian Rosewell, Alberto Quaglia, Axel Behrens
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 966-978 (2017)
Summary: The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophy
Externí odkaz:
https://doaj.org/article/6fdd133864f14223b3c2f5abfdfe6119
Publikováno v:
PLoS Biology, Vol 11, Iss 6, p e1001586 (2013)
FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct s
Externí odkaz:
https://doaj.org/article/f5fb39c356274714acdaf7ed508dfa86
Publikováno v:
Cell Stem Cell. 30:345-347
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a3dda4839aefbf144f9dbc408c3178
https://doi.org/10.1016/j.stem.2023.03.002
https://doi.org/10.1016/j.stem.2023.03.002
Autor:
Ana-Maria Cujba, Mario E. Alvarez-Fallas, Sergio Pedraza-Arevalo, Anna Laddach, Maggie H. Shepherd, Andrew T. Hattersley, Fiona M. Watt, Rocio Sancho
Publikováno v:
Cell Reports. 38:110425
The HNF1α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3967fde113ae79b7a3dd4012102cb7
https://doi.org/10.1016/j.celrep.2022.110425
https://doi.org/10.1016/j.celrep.2022.110425
Autor:
Mario Enrique Alvarez Fallas, Sergio Pedraza-Arevalo, Teodora Manea, Rocio Sancho, Ana-Maria Cujba, Christopher Lambert, Rosario Morrugares
Publikováno v:
Molecular and Cellular Endocrinology
Though embryonic pancreas progenitors are well characterised, the existence of stem/progenitor cells in the postnatal mammalian pancreas has been long debated, mainly due to contradicting results on regeneration after injury or disease in mice. Despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a6642a3e5b6da6e6f08948056e51c9
https://pubmed.ncbi.nlm.nih.gov/34543699
https://pubmed.ncbi.nlm.nih.gov/34543699
Autor:
Rocio Sancho, Axel Behrens, Harry Heimberg, Ella-Louise Hubber, Chloe L. Rackham, Christopher Gribben, Hendrik A. Messal, Christopher Lambert, Peter M. Jones, Ian Evans
Publikováno v:
Cell stem cell. 28(11)
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35452e916541f713a16b7c4d28d23deb
https://pubmed.ncbi.nlm.nih.gov/34739830
https://pubmed.ncbi.nlm.nih.gov/34739830