Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rocio Rebollido-Rios"'
Autor:
Andrea Escolar-Peña, María Isabel Delgado-Dolset, Carmela Pablo-Torres, Carlos Tarin, Leticia Mera-Berriatua, María del Pilar Cuesta Apausa, Heleia González Cuervo, Rinku Sharma, Alvin T. Kho, Kelan G. Tantisira, Michael J. McGeachie, Rocio Rebollido-Rios, Domingo Barber, Teresa Carrillo, Elena Izquierdo, María M. Escribese
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9425 (2024)
The mechanisms underlying severe allergic asthma are complex and unknown, meaning it is a challenge to provide the most appropriate treatment. This study aimed to identify novel biomarkers for stratifying allergic asthmatic patients according to seve
Externí odkaz:
https://doaj.org/article/e36d386bf41845c6b7591bde898e3e41
Autor:
Floyd Hassenrück, Maria Farina-Morillas, Lars Neumann, Francesco Landini, Stuart James Blakemore, Mina Rabipour, Juan Raul Alvarez-Idaboy, Christian P. Pallasch, Michael Hallek, Rocio Rebollido-Rios, Günter Krause
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Targeting the PI3K isoform p110δ against B cell malignancies is at the mainstay of PI3K inhibitor (PI3Ki) development. Therefore, we generated isogenic cell lines, which express wild type or mutant p110δ, for assessing the potency, isoform
Externí odkaz:
https://doaj.org/article/69f0d2808dd345ce9c545e0a14f5e38c
Autor:
Alexander F. vom Stein, Rocio Rebollido-Rios, Anna Lukas, Maximilian Koch, Anton von Lom, Sebastian Reinartz, Daniel Bachurski, France Rose, Katarzyna Bozek, Ali T. Abdallah, Viktoria Kohlhas, Julia Saggau, Rebekka Zölzer, Yue Zhao, Christiane Bruns, Paul J. Bröckelmann, Philipp Lohneis, Reinhard Büttner, Björn Häupl, Thomas Oellerich, Phuong-Hien Nguyen, Michael Hallek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The survival of chronic lymphocytic leukemia cells strongly depends on the presence of a supportive microenvironment. Here, the authors show that LYN kinase is essential for the reprogramming of stromal cells towards a leukemia-supportive phenotype t
Externí odkaz:
https://doaj.org/article/5884daf4f87c4769b8607b371a457bb5
Autor:
Arthur T. Porfetye, Patricia Stege, Rocio Rebollido-Rios, Daniel Hoffmann, Thomas Schrader, Ingrid R. Vetter
Publikováno v:
Molecules, Vol 29, Iss 8, p 1764 (2024)
To understand the biological relevance and mode of action of artificial protein ligands, crystal structures with their protein targets are essential. Here, we describe and investigate all known crystal structures that contain a so-called “molecular
Externí odkaz:
https://doaj.org/article/64b2d97b96ff4a429781cd50dd2874b9
Autor:
Thaís Dolzany de Oliveira, Alexander vom Stein, Rocio Rebollido-Rios, Liudmila Lobastova, Marcus Lettau, Ottmar Janssen, Prerana Wagle, Phuong-Hien Nguyen, Michael Hallek, Hinrich P. Hansen
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
IntroductionIn chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and extracellular vesicles (EVs). The protein tyrosine kinase Lyn is aberrantly expressed in t
Externí odkaz:
https://doaj.org/article/3236639ca318479aadab9276f50874a5
Autor:
Sabine Schürmann, Georg Steffes, Dominique Manikowski, Philipp Kastl, Ursula Malkus, Shyam Bandari, Stefanie Ohlig, Corinna Ortmann, Rocio Rebollido-Rios, Mandy Otto, Harald Nüsse, Daniel Hoffmann, Christian Klämbt, Milos Galic, Jürgen Klingauf, Kay Grobe
Publikováno v:
eLife, Vol 7 (2018)
Cell fate determination during development often requires morphogen transport from producing to distant responding cells. Hedgehog (Hh) morphogens present a challenge to this concept, as all Hhs are synthesized as terminally lipidated molecules that
Externí odkaz:
https://doaj.org/article/6a0f74376f5b4faab692c9a25021d50d
Autor:
Rocio Rebollido-Rios, Shyam Bandari, Christoph Wilms, Stanislav Jakuschev, Andrea Vortkamp, Kay Grobe, Daniel Hoffmann
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003707 (2014)
Sonic Hedgehog (Shh) is a representative of the evolutionary closely related class of Hedgehog proteins that have essential signaling functions in animal development. The N-terminal domain (ShhN) is also assigned to the group of LAS proteins (LAS = L
Externí odkaz:
https://doaj.org/article/502fc271de80432498502d7e87632d15
Autor:
Elena Izquierdo, Daniela Vorholt, Stuart Blakemore, Benedict Sackey, Janica L. Nolte, Verena Barbarino, Jan Schmitz, Nadine Nickel, Daniel Bachurski, Liudmila Lobastova, Milos Nikolic, Michael Michalik, Reinhild Brinker, Olaf Merkel, Marek Franitza, Theodoros Georgomanolis, René Neuhaus, Maximilian Koch, Niklas Nasada, Gero Knittel, Björn Chapuy, Nicole Ludwig, Eckart Meese, Lukas Frenzel, Hans Christian Reinhardt, Martin Peifer, Rocio Rebollido-Rios, Heiko Bruns, Marcus Krüger, Michael Hallek, Christian P. Pallasch
Publikováno v:
Blood. 139:3617-3629
Genetic alterations in the DNA damage response (DDR) pathway are a frequent mechanism of resistance to chemoimmunotherapy (CIT) in B-cell malignancies. We have previously shown that the synergy of CIT relies on secretory crosstalk elicited by chemoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867f322a77685263f8de9140fd2b9f05
https://doi.org/10.1182/blood.2021014007
https://doi.org/10.1182/blood.2021014007
Autor:
Wei-Cheng Tung, Njara Rakotomanomana, Bryan Rizzo, Joe A. Vinson, Yusef Dabbagh, Paul W. Needs, Olivier Dangles, Paul A. Kroon, Mark Romanczyk, Suraj Saraswat, Rocio Rebollido-Rios, Edelsys Codorniu-Hernández, Karen Weikel
Publikováno v:
Archives of Biochemistry and Biophysics
Archives of Biochemistry and Biophysics, Elsevier, 2020, 694, pp.108589. ⟨10.1016/j.abb.2020.108589⟩
Archives of Biochemistry and Biophysics, Elsevier, 2020, 694, pp.108589. ⟨10.1016/j.abb.2020.108589⟩
International audience; There is ample evidence in the epidemiological literature that polyphenols, the major non-vitamin antioxidants in plant foods and beverages, have a beneficial effect on heart disease. Until recently other mechanisms which poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab41e4f9a48583459db9592e3be71ad8
https://hal.inrae.fr/hal-03087949
https://hal.inrae.fr/hal-03087949
Autor:
Michael Michalik, Janica L. Nolte, Christian P. Pallasch, Michael Hallek, Milos Nikolic, Lukas P. Frenzel, Benedict Sackey, Jan Schmitz, Verena Barbarino, Martin Peifer, Marcus Krüger, Heiko Bruns, René Neuhaus, Maximilian Koch, Stuart Blakemore, Olaf Merkel, Hans Christian Reinhardt, Daniela Vorholt, Ludmila Lobastova, Reinhild Brinker, Nadine Nickel, Elena Izquierdo, Daniel Bachurski, Rocio Rebollido-Rios, Gero Knittel
SummaryChemoimmunotherapy (CIT) is the standard of care in B-cell malignancies. It is relying on synergistic effects of alkylating chemotherapy and monoclonal antibodies via secretory crosstalk with effector macrophages. Here, we observed that loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c29d8c2d9393a1efd344273e8797fe9
https://doi.org/10.1101/2020.06.11.145268
https://doi.org/10.1101/2020.06.11.145268