Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rocio Palma"'
Autor:
Claudia Milena Roa Flórez, Laura María Espinosa Giraldo, Ivonne Rocio Palma Motta, María Alejandra Castillo Delgado, Luis Alberto López Pérez, Julieta Bermúdez Alarcón, Jaime Rodrigo Rivera Barrero
Publikováno v:
Revista Cubana de Estomatología, Vol 61, Iss 0, Pp e4884-e4884 (2024)
Introduction: Apical surgeries are routinely performed in Endodontic postgraduate courses at institutions of higher education. Although the success rate and intraoperative prognostic factors of these interventions have been determined in previous stu
Externí odkaz:
https://doaj.org/article/48b60bdf7be3408b8d1f5c9db0a473e5
Autor:
Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Karen Bresciano, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Terence Hall, Jason Hill, Eoin Kelleher, Sampada Khanapurkar, Darin Kizer, Steffi Koerner, Jeff Link, Yanbin Liu, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Khanh Nguyen, Robert Nicewonger, Rocio Palma, Jeff Szwaya, Manish Tandon, Uma Uppalapati, David Vensel, Laurie P. Volak, Erika Volckova, Neil Westlund, Hui Wu, Rui-Yang Yang, Thomas C. K. Chan
Publikováno v:
Journal of Medicinal Chemistry. 55:5291-5310
This paper describes the implementation of a biochemical and biophysical screening strategy to identify and optimize small molecule Akt1 inhibitors that act through a mechanism distinct from that observed for kinase domain ATP-competitive inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035e1cfbf07fe3d046c0f43f58f30c37
https://doi.org/10.1021/jm300276x
https://doi.org/10.1021/jm300276x
Autor:
Sudharshan, Eathiraj, Rocio, Palma, Marscha, Hirschi, Erika, Volckova, Enkeleda, Nakuci, Jennifer, Castro, Chang-Rung, Chen, Thomas C K, Chan, Dennis S, France, Mark A, Ashwell
Publikováno v:
The Journal of biological chemistry. 286(23)
Protein kinase inhibitors with enhanced selectivity can be designed by optimizing binding interactions with less conserved inactive conformations because such inhibitors will be less likely to compete with ATP for binding and therefore may be less im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4080ba3e8ecb351624ad074f72bb215
https://pubmed.ncbi.nlm.nih.gov/21454610
https://pubmed.ncbi.nlm.nih.gov/21454610
Autor:
Sudharshan Eathiraj, Rocio Palma, Erika Volckova, Marscha Hirschi, Dennis S. France, Mark A. Ashwell, Thomas C.K. Chan
A number of human malignancies exhibit sustained stimulation, mutation, or gene amplification of the receptor tyrosine kinase human mesenchymal-epithelial transition factor (c-Met). ARQ 197 is a clinically advanced, selective, orally bioavailable, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebe6ae26d24afa5e13966dcf3f7a145
https://europepmc.org/articles/PMC3121448/
https://europepmc.org/articles/PMC3121448/
Autor:
Rocio Palma
Publikováno v:
International Journal of Quantum Chemistry. 48:117-125
In this paper, we describe the heat-capacity changes under heating as a process defined by phonon–vibrational exciton interactions. Following Davidov, we describe an α-helix as three noninteracting linear molecular crystals. Further development is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4f155de2ef186116cb91a2c74824f5f
https://doi.org/10.1002/qua.560480714
https://doi.org/10.1002/qua.560480714
Autor:
Rocio Palma
Publikováno v:
International Journal of Quantum Chemistry. 44:167-177
The aim of this paper was to establish a distribution function for the number of vibrational excitons in a given state N(r,k) for describing the energy-transfer process along α-helical proteins under normal physiological conditions. In the backgroun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad8b11899bfa60cdea3108b112fa4bd4
https://doi.org/10.1002/qua.560440716
https://doi.org/10.1002/qua.560440716
Autor:
Rocio Palma, Alan Beresford, Mary-Margaret O’Donnell, Donglai Yang, Alex Porte, David Vensel, Manish Tandon, Mark A. Ashwell
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(7)
New arylpiperazines related to buspirone, gepirone and NAN-190 were designed and screened in silico for their 5-HT 1A affinity and potential sites of metabolism by human cytochrome P450 (CYP3A4). Modifications to these structures were assessed in sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709d32641721cb8dfb0ddd3530d2cf88
https://pubmed.ncbi.nlm.nih.gov/15026055
https://pubmed.ncbi.nlm.nih.gov/15026055
Publikováno v:
ACS Symposium Series ISBN: 9780841236813
Glycosyl Hydrolases for Biomass Conversion
Glycosyl Hydrolases for Biomass Conversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb928b39f0fb1a3dd2ac8bccd6b8c6af
https://doi.org/10.1021/bk-2001-0769.ch007
https://doi.org/10.1021/bk-2001-0769.ch007
Autor:
Paul M. G. Curmi, Rocio Palma
Publikováno v:
Protein science : a publication of the Protein Society. 8(4)
Thermal stability of mutant proteins has been investigated using temperature dependent molecular dynamics (MD) simulations in vacuo. The numerical modeling was aimed at mimicking protein expansion upon heating. After the conditions for an expanding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a52d374e36be38fa92ac2b68a3380d
https://pubmed.ncbi.nlm.nih.gov/10211838
https://pubmed.ncbi.nlm.nih.gov/10211838
Autor:
Syed M. Ali, Chris Brassard, Audra Dalton, Darin Kizer, Jean-Marc Lapierre, Yanbin Liu, Magdi Moussa, Rocio Palma, Manish Tandon, David Vensel, Erika Volckova, Jianqiang Wang, Neil Westlund, Hui Wu, Rui-Yang Yang, Craig Bates, Mayank Bhavsar, Cathy Bull, Sudharshan Eathiraj, Robert Nicewonger, Ron Savage, Carol Waghorne, Jennifer Castro, Enkeleda Nakuci, Chang-Rung Chen, Dennis S. France, Thomas C.K. Chan, Mark A. Ashwell
Publikováno v:
Cancer Research. 72:3905-3905
Utilization of hydrophobic motifs present in auto-inhibited protein kinases has resulted in the identification of a series of 5,6-dihydrobenzo [h]quinazolin-2-amines with activity as fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3f2f570d6e9677ed33340d22c18292f
https://doi.org/10.1158/1538-7445.am2012-3905
https://doi.org/10.1158/1538-7445.am2012-3905