Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rocio I.R. Macías"'
Publikováno v:
Annals of Hepatology, Vol 4, Iss 2, Pp 70-76 (2005)
Since the excretion of potentially toxic cholephilic organic anions (COAs) produced by the fetus, such as bile acids and biliary pigments, cannot be performed by the fetal liver alone, the placenta and the maternal liver must play a key role collabor
Externí odkaz:
https://doaj.org/article/3c00e8cfb350498a81a7ecca34930997
Autor:
Sara Ortiz-Rivero, Ana Peleteiro-Vigil, Lorena Abete, Elisa Lozano, Helen S. Hammer, Silvia Di Giacomo, Mar Abad, Loreto Boix, Alejandro Forner, Maria Reig, Rocio I.R. Macias, Oliver Pötz, Jose J.G. Marin, Oscar Briz
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116038- (2024)
Cholangiocarcinomas (CCAs) are cancers originated in the biliary tree, which are characterized by their high mortality and marked chemoresistance, partly due to the activity of ATP-binding cassette (ABC) export pumps, whose inhibition has been propos
Externí odkaz:
https://doaj.org/article/b4843168fecc49a9b5509ab1be898085
Autor:
Corentin Louis, Tanguy Ferlier, Raffaële Leroux, Raphaël Pineau, Matthis Desoteux, Panagiotis Papoutsoglou, Delphine Leclerc, Gaëlle Angenard, Javier Vaquero, Rocio I.R. Macias, Julien Edeline, Cédric Coulouarn
Publikováno v:
JHEP Reports, Vol 5, Iss 12, Pp 100900- (2023)
Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide with an increasing incidence and limited therapeutic options. Therefore, there is an urgent need to open the field to new concepts for identifying clinically relev
Externí odkaz:
https://doaj.org/article/d65272770452400784fb8235c71e509e
Autor:
Paula Sanchon-Sanchez, Oscar Briz, Rocio I.R. Macias, Mar Abad, Anabel Sanchez-Martin, Jose J.G. Marin, Elisa Lozano
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115658- (2023)
Background: Cholangiocarcinoma (CCA) is a highly lethal cancer originated in the biliary tree. Available treatments for CCA are scarcely effective, partly due to mechanisms of chemoresistance, such as aberrant activation of Wnt/β-catenin pathway and
Externí odkaz:
https://doaj.org/article/e797006f33624a438f7af18324ca912f
Autor:
Monika Lewinska, PhD, Alvaro Santos-Laso, PhD, Enara Arretxe, PhD, Cristina Alonso, PhD, Ekaterina Zhuravleva, PhD, Raul Jimenez-Agüero, MD, PhD, Emma Eizaguirre, MD, PhD, María Jesús Pareja, MD, PhD, Manuel Romero-Gómez, MD, PhD, Marco Arrese Jimenez, MD, PhD, Malte P. Suppli, MD, PhD, Filip K. Knop, MD, PhD, Stine Karlsen Oversoe, MD, PhD, Gerda Elisabeth Villadsen, MD, PhD, Thomas Decaens, MD, PhD, Flair Jose Carrilho, MD, PhD, Claudia PMS de Oliveira, MD, PhD, Bruno Sangro, MD, PhD, Rocio I.R. Macias, MD, PhD, Jesus M. Banales, PhD, Jesper B. Andersen, PhD
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103661- (2021)
Background: Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of metabolic dysfunctions that can progress to hepatocellular carcinoma (NAFLD-HCC). This development can occur in a non-cirrhotic li
Externí odkaz:
https://doaj.org/article/a98663c5714b4b39a2da1a493b1539b3
Autor:
Ainhoa Lapitz, Ander Arbelaiz, Colm J. O’Rourke, Jose L. Lavin, Adelaida La Casta, Cesar Ibarra, Juan P. Jimeno, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Marcin Krawczyk, Maria J. Perugorria, Raul Jimenez-Aguero, Alberto Sanchez-Campos, Ioana Riaño, Esperanza Gónzalez, Frank Lammert, Marco Marzioni, Rocio I.R. Macias, Jose J. G. Marin, Tom H. Karlsen, Luis Bujanda, Juan M. Falcón-Pérez, Jesper B. Andersen, Ana M. Aransay, Pedro M. Rodrigues, Jesus M. Banales
Publikováno v:
Cells, Vol 9, Iss 3, p 721 (2020)
Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and ac
Externí odkaz:
https://doaj.org/article/3b3b763b3a064cf0b5e939942071ce9a
Autor:
Jose J.G. Marin, Rocio I.R. Macias, Candela Cives-Losada, Ana Peleteiro-Vigil, Elisa Herraez, Elisa Lozano
Publikováno v:
Cells, Vol 9, Iss 2, p 498 (2020)
The dismal prognosis of patients with advanced cholangiocarcinoma (CCA) is due, in part, to the extreme resistance of this type of liver cancer to available chemotherapeutic agents. Among the complex mechanisms accounting for CCA chemoresistance are
Externí odkaz:
https://doaj.org/article/5939db0de36e49708baab083bd1bef2c
Publikováno v:
Journal of Functional Foods, Vol 5, Iss 3, Pp 1170-1179 (2013)
The present study investigated the antioxidant and cytoprotective effects of purified ethanolic extracts of Cytisus multiflorus, Lamium album L. and Thymus citriodorus plants. These extracts showed high antioxidant activity in DPPH and reducing power
Externí odkaz:
https://doaj.org/article/2a37667ddaa1458398a73999755311c8
Autor:
Susana Cuesta de Juan, Maria J. Monte, Rocio I.R. Macias, Valérie Wauthier, Pedro Buc Calderon, Jose J.G. Marin
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1362-1370 (2007)
Ontogenic changes in the rat bile acid (BA) pool, measured enzymatically and by GC-MS, and expression of enzymes (5α-reductase, 5β-reductase, and cytochrome P450 enzymes Cyp7a1, Cyp8b1, Cyp27 and Cyp3a11), transporters [bile salt export pump, sodiu
Externí odkaz:
https://doaj.org/article/f97c76c1a801447eb8b70a682d6e5643
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 9, Pp 1792-1798 (1998)
Rat liver uptake and bile output of the cytostatic complex cis-diammineplatinum(II)-chlorocholylglycinate (Bamet-R2) were studied. Up to 100 μm, Bamet-R2 uptake by rat hepatocytes in primary culture followed saturation kinetics (Vmax = 0.65 ± 0.12
Externí odkaz:
https://doaj.org/article/67c6a9a3ef844e41a8886d1e1a5786f4