Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration

Autor: Min Zhao, Irmela Mantel, Emmanuelle Gelize, Xinxin Li, Xiaoyue Xie, Alejandro Arboleda, Marie Seminel, Rinath Levy-Boukris, Marilyn Dernigoghossian, Andrea Prunotto, Charlotte Andrieu-Soler, Carlo Rivolta, Jérémie Canonica, Marie-Christine Naud, Sebastian Lechner, Nicolette Farman, Irene Bravo-Osuna, Rocio Herrero-Vanrell, Frederic Jaisser, Francine Behar-Cohen

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisa

Externí odkaz: https://doaj.org/article/38bef37aaba649d6a6734776e59801e9

Gelatin Nanoparticles-HPMC Hybrid System for Effective Ocular Topical Administration of Antihypertensive Agents

Autor: Sergio Esteban-Pérez, Vanessa Andrés-Guerrero, José Javier López-Cano, Irene Molina-Martínez, Rocio Herrero-Vanrell, Irene Bravo-Osuna

Publikováno v: Pharmaceutics, Vol 12, Iss 4, p 306 (2020)

The increment in ocular drug bioavailability after topical administration is one of the main challenges in pharmaceutical technology. For several years, different strategies based on nanotechnology, hydrogels or implants have been evaluated. Nowadays

Externí odkaz: https://doaj.org/article/94f806ed95194f159cda70eb8272ef04

Development of injectable thermoresponsive Cs‐g‐PNIPAAm hydrogel for intrascleral drug delivery of sunitinib malate for the posterior segment ocular disease, age‐related macular degeneration

Autor: Shilpkala Gade, Eneko Larraneta, Ryan F. Donnelly, Rocio Herrero Vanrell, Carmen Alvarez‐Lorenzo, Raghu Raj Singh Thakur

Publikováno v: Acta Ophthalmologica. 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fa8afdfb0379b010299199ce08304ca
https://doi.org/10.1111/j.1755-3768.2022.15542

Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib

Autor: Shilpkala Gade, Eneko Larrañeta, Ryan F Donnelly, Rocio Herrero Vanrell, Carmen Isabel Alvarez Lorenzo, Raghu Raj Singh Thakur

Publikováno v: Gade, S, Larrañeta, E, Donnelly, R F, Vanrell, R H, Alvarez-Lorenzo, C I & Thakur, R R S 2022, ' Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib ', British Journal of Pharmacy, vol. 7, no. 2, 1175, pp. S1-S2 . https://doi.org/10.5920/bjpharm.1175

Age-related macular degeneration (AMD) is a potentially blinding posterior segment disease; inflammatory responses and subretinal drusen formation lead to leaky blood vessels. The current treatment method involves intravitreal injections of anti-VEGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb83491a502a7cc1368f0c318a8b52d
https://pure.qub.ac.uk/en/publications/4591cda9-119e-46d0-94a3-7dfd10020163

Artificial Tears: Biological Role of Their Ingredients in the Management of Dry Eye Disease

Autor: Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
Universitad de Lleida

Dry eye disease (DED) is the most common ocular surface disease, characterized by insufficient production and/or instability of the tear film. Tear substitutes are usually the first line of treatment for patients with DED. Despite the large variety o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aff0facc88dcf2fefe7a7a51ebed8d
https://doi.org/10.3390/ijms23052434