Výsledky vyhledávání - "Rochelle M. Witt"

Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry

Autor: Sandeep Robert Datta, Adriana Eisner, Laura Persson, Paul L. Greer, Rosalind A. Segal, Maria F. Pazyra-Murphy, Rochelle M. Witt, Meghan M. Galligan

Publikováno v: Developmental Neurobiology. 74:1255-1267

The olfactory system relies on precise circuitry connecting olfactory sensory neurons (OSNs) and appropriate relay and processing neurons of the olfactory bulb (OB). In mammals, the exact correspon- dence between specific olfactory receptor types and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e248580c6fabbeef6e7297e43743a8f2
https://doi.org/10.1002/dneu.22202

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Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

Autor: Margaret A. Thompson, Yoojin Choi, Jennifer A. Chan, Rosalind A. Segal, Carolyn O Walsh, Maria F. Pazyra-Murphy, Srividya Balasubramanian, Rochelle M. Witt, Kellie J. Nazemi

Publikováno v: Nature neuroscience

Sonic Hedgehog (Shh) has dual roles in vertebrate development, promoting progenitor cell proliferation and inducing tissue patterning. We found that the mitogenic and patterning functions of Shh can be uncoupled from one another. Using a genetic appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82374bc4058254f6476bbbeef2e38983
http://europepmc.org/articles/PMC2676236

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Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling

Autor: Vijaya Ramesh, Rochelle M. Witt, Carolyn Polizzano, Sangyeul Han, Túlio M. Santos, Bernardo L. Sabatini

Publikováno v: Cellular Signalling. 20:1084-1091

The tumor suppressor tuberin, encoded by the Tuberous Sclerosis Complex (TSC) gene TSC2, negatively regulates the mammalian target of rapamycin (mTOR) pathway, which plays a key role in the control of cell growth and proliferation. In addition to nat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca4b3822c3b9f5d1d406423e7b69d47
https://doi.org/10.1016/j.cellsig.2008.01.020

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Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

Autor: Samuel M. Cohen, Christian Noti, Jennifer A. Chan, Toin H. van Kuppevelt, Rosalind A. Segal, Peter H. Seeberger, Rochelle M. Witt, Maria F. Pazyra-Murphy, Marie-Lyn Hecht, John J. Hopwood, Maria Fuller

Publikováno v: Journal of Biological Chemistry, 288, 26275-88
Journal of Biological Chemistry
Journal of Biological Chemistry, 288, 36, pp. 26275-88

Contains fulltext : 119295.pdf (Publisher’s version ) (Open Access) Sonic Hedgehog (Shh) signaling is crucial for growth, cell fate determination, and axonal guidance in the developing nervous system. Although the receptors Patched (Ptch1) and Smoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbc696f7662f5eeec8a03454608dad5
http://hdl.handle.net/2066/119295

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Olfactory Behavioral Testing in the Adult Mouse

Autor: Meghan M. Galligan, Rosalind A. Segal, Rochelle M. Witt, Jennifer R. Despinoy

Publikováno v: Journal of Visualized Experiments : JoVE

The rodent olfactory system is of increasing interest to scientists, studied, in part, in systems biology because of its stereotyped, yet accessible circuitry. In addition, this area's unique ability to generate new neurons throughout an organism's l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5ae4d7e9abeb914e69ea29c2a0029e
http://europepmc.org/articles/PMC2782999

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A Novel Computational Approach for Automatic Dendrite Spines Detection in Two-Photon Laser Scan Microscopy

Autor: Xiaobo Zhou, Jinmin Zhu, Rochelle M. Witt, Eric L. Miller, Jie Cheng, Steven T.C. Wong, Bernardo L. Sabatini

Background Recent research has shown that there is a strong correlation between the functional properties of a neuron and its morphologic structure. Current morphologic analyses typically involve a significant component of computer-assisted manual la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa22c34505f19a8e0b70aff33e56d4f0
https://europepmc.org/articles/PMC1989684/

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Automated Spine Detection Using Curvilinear Structure Detector and LDA Classifier

Autor: Stephen T. C. Wong, Xiaobo Zhou, Donald A. Adjeroh, Yong Zhang, Rochelle M. Witt, Bernardo L. Sabatini

Publikováno v: ISBI

Dendritic spines are small, bulbous cellular compartments that carry synapses. Biologists have been studying the biochemical pathways by examining the morphological and statistical changes of the dendritic spines at the intracellular level. In this p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5e42388cbe364080eed7fa8d2e45afc
https://doi.org/10.1109/isbi.2007.356905

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Dendritic spine detection using curvilinear structure detector and LDA classifier

Autor: Yong Zhang, Rochelle M. Witt, Stephen T. C. Wong, Xiaobo Zhou, Donald A. Adjeroh, Bernardo L. Sabatini

Publikováno v: NeuroImage. 36(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8caeb80178a80f9942735a895f29278a
https://pubmed.ncbi.nlm.nih.gov/17448688

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A Shape Analysis Method to Detect Dendritic Spine in 3D Optical Microscopy Image

Autor: Rochelle M. Witt, Xiaoyin Xu, Bernardo L. Sabatini, Stephen T. C. Wong, Jie Cheng

Publikováno v: ISBI

Dendritic spines play an important role in synaptic transmission. Spines are small protrusions formed on the shafts of dendrites and they are manifest of many neurological conditions. Three dimensional images of dendrites and spines are obtained by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::166ec7ec7a0e2550cc86ba5559e52ee7
https://doi.org/10.1109/isbi.2006.1624976

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