Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rochelle M. Maher"'
Autor:
Joseph W. Fay, Richard A. Nash, Jin Zhu, Donna Przepiorka, John R. Wingard, Voravit Ratanatharathorn, Rochelle M. Maher, Daniel J Weisdorf, J. L. Klein, William E. Fitzsimmons
Publikováno v:
Biology of Blood and Marrow Transplantation. 4(3):157-163
A randomized clinical trial comparing tacrolimus with cyclosporine, both with short-course methotrexate, as prophylaxis against graft-vs.-host disease (GVHD) in allogeneic HLA-matched sibling bone marrow transplant patients was conducted. Cyclosporin
Autor:
Joseph H. Antin, Rein Saral, John R. Wingard, Rochelle M. Maher, Robert H. Collins, Joseph W. Fay, Daniel J. Weisdorf, Barbara E. Bierer, L. Pineiro, Donna Przepiorka, Bruce R. Blazar, William E. Fitzsimmons
Publikováno v:
Blood. 87:3514-3519
FK506 (Tacrolimus) is an immunosuppressive drug that blocks the activation of antigen-specific T lymphocytes, a major component in the pathogenesis of graft-versus-host disease (GVHD). This study was designed to obtain first estimates of the safety a
Lack of interaction between tacrolimus (FK506) and methotrexate in bone marrow transplant recipients
Autor:
I Bekersky, Richard A. Nash, GW Boswell, Donna Przepiorka, Steve Devine, JL Klein, Rochelle M. Maher, John R. Wingard, Joseph W. Fay, Voravit Ratanatharathorn, William E. Fitzsimmons
Publikováno v:
Bone Marrow Transplantation. 20:49-51
Tacrolimus (FK506) is a macrolide lactone effective in the control of graft-versus-host disease (GVHD). An interaction between high-dose methotrexate and a macrolide antibiotic (pristinamycin) leading to prolonged methotrexate exposure has been descr
Autor:
Donna Przepiorka, Mary M. Horowitz, Chun Huang, Ellen Hodosh, Rochelle M. Maher, Jay Erdman, Donald N. Buell, Pamela Bartels, Mei-Jie Zhang, John R. Wingard, William E. Fitzsimmons
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 5(3)
A phase HI comparative trial of tacrolimus- vs. cyclosporine-based graft-vs.-host disease (GVHD) prophylaxis for human leukocyte antigen (HLA)-identical sibling bone marrow transplantation showed less GVHD but poorer survival in the tacrolimus arm. T
Autor:
Joseph H. Antin, Richard A. Nash, Daniel J. Weisdorf, John R. Wingard, Rochelle M. Maher, William E. Fitzsimmons, GW Boswell, Joseph W. Fay, I Bekersky
Publikováno v:
Bone marrow transplantation. 21(1)
The pharmacokinetics of tacrolimus following its administration as monotherapy or in combination with corticosteroids or methotrexate to 31 BMT patients are presented. All patients received i.v. tacrolimus initially and were subsequently switched to
Autor:
John R. Wingard, Jin Zhu, Richard A. Nash, Donna Przepiorka, Rochelle M. Maher, William E. Fitzsimmons, Joseph W. Fay
Publikováno v:
Biology of Blood and Marrow Transplantation. (2):94-97
Tacrolimus has proved effective for preventing acute graft-vs.-host disease (GVHD) after unrelated donor marrow transplantation, but the therapeutic window is apparently narrow. Therapeutic drug monitoring could potentially be used to guide dose modi