Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rochelle Ayala-Perez"'
Autor:
Anthony W. Purcell, Nadine L. Dudek, Philippa M. Saunders, Jon E. Mangum, Sheena Wee, Ralf B. Schittenhelm, Dhana G. Gorasia, Rochelle Ayala Perez, Helena Safavi-Hemami, Michael J. Hubbard
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1864:715-723
Despite its critical role in maintaining glucose homeostasis, surprisingly little is known about proinsulin folding in the endoplasmic reticulum. In this study we aimed to understand the chaperones involved in the maturation and degradation of proins
Autor:
Nathan P. Croft, Rochelle Ayala-Perez, Nadine L. Dudek, Patricia T. Illing, Kai L Giam, Anthony W. Purcell, Ralf B. Schittenhelm
Publikováno v:
Tissue Antigens. 85:492-496
Human leukocyte antigen (HLA)-A1 is one of the most common Caucasian HLA-A alleles. Here, we describe the comprehensive analysis of the HLA-A*01:01 ligand repertoire with the identification of 4735 naturally processed and presented peptides derived f
Autor:
Rochelle Ayala-Perez, Robyn Maree Slattery, Helen E. Thomas, Balasubramanian Krishnamurthy, Stacey Fynch, Thomas W.H. Kay, Pere Santamaria, Kate L. Graham
Publikováno v:
European Journal of Immunology. 42:1717-1722
Infiltration of pancreatic islets by immune cells, termed insulitis, increases progressively once it begins and leads to clinical type 1 diabetes. But even after diagnosis some islets remain unaffected and infiltration is patchy rather than uniform.
Autor:
Thomas W.H. Kay, Helen E. Thomas, Janette Allison, Sarah Emmett, Pere Santamaria, Kate L. Graham, Eveline Angstetra, Rochelle Ayala-Perez, Rima Darwiche, Nadine L. Dudek
Publikováno v:
Immunology & Cell Biology. 87:178-185
CD4(+) T cells can actively kill beta-cells in type I diabetes as well as help CD8(+) T cells become cytolytic. Cytokines have the potential to kill beta-cells, or upregulate Fas on beta-cells, and increase their susceptibility to FasL. We investigat
Autor:
Kate L, Graham, Balasubramanian, Krishnamurthy, Stacey, Fynch, Rochelle, Ayala-Perez, Robyn M, Slattery, Pere, Santamaria, Helen E, Thomas, Thomas W H, Kay
Publikováno v:
European journal of immunology. 42(7)
Infiltration of pancreatic islets by immune cells, termed insulitis, increases progressively once it begins and leads to clinical type 1 diabetes. But even after diagnosis some islets remain unaffected and infiltration is patchy rather than uniform.