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Akademický článek

Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells.

Autor: Rodrigues ACBDC; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil., Bomfim LM; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil., Neves SP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil., Soares MBP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil; SENAI Institute for Innovation in Advanced Health Systems, SENAI CIMATEC, Salvador, BA 41650-010, Brazil., Dias RB; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil; Department of Clinical Propaedeutics and Integrated Clinical, Faculty of Dentistry, Federal University of Bahia (UFBA), Salvador, Bahia 40301-155, Brazil., Valverde LF; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil., Rocha CAG; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil; Department of Clinical Propaedeutics and Integrated Clinical, Faculty of Dentistry, Federal University of Bahia (UFBA), Salvador, Bahia 40301-155, Brazil., Costa EV; Department of Chemistry, Federal University of Amazonas (UFAM), Manaus, Amazonas 69080-900, Brazil., da Silva FMA; Department of Chemistry, Federal University of Amazonas (UFAM), Manaus, Amazonas 69080-900, Brazil., Rocha WC; Health and Biotechnology Institute, Federal University of Amazonas (UFAM), Coari, Amazonas 69460-000, Brazil., Koolen HHF; Metabolomics and Mass Spectrometry Research Group, Amazonas State University (UEA), Manaus, Amazonas 690065-130, Brazil., Bezerra DP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador, Bahia 40296-710, Brazil. Electronic address: daniel.bezerra@fiocruz.br.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Oct; Vol. 142, pp. 112034. Date of Electronic Publication: 2021 Aug 16.

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Akademický článek

22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling.

Autor: Aranha ESP; Faculty of Pharmaceutical Sciences, Post Graduate Program in Biodiversity and Biotechnology of the Amazon (Bionorte), Federal University of Amazonas, Manaus, Amazonas, 69080-900, Brazil. Electronic address: elenn_suzany@yahoo.com.br., Portilho AJS; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil. Electronic address: dryportilhoo@gmail.com., Bentes de Sousa L; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, 69080-900, Brazil. Electronic address: leilane.bentes@gmail.com., da Silva EL; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil. Electronic address: lucenaemerson@hotmail.com., Mesquita FP; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil. Electronic address: felipe_mesquita05@hotmail.com., Rocha WC; Health and Biotechnology Institute, Federal University of Amazonas, Coari, Amazonas, 69460-000, Brazil. Electronic address: wal2002@gmail.com., Araújo da Silva FM; Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, 69080-900, Brazil. Electronic address: felipesaquarema@bol.com.br., Lima ES; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, 69080-900, Brazil. Electronic address: eslima75@gmail.com., Alves APNN; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil. Electronic address: ananegreirosnunes@gmail.com., Koolen HHF; Metabolomics and Mass Spectrometry Research Group, Amazonas State University (UEA), Manaus, Amazonas, 690065-130, Brazil. Electronic address: hectorkoolen@gmail.com., Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil. Electronic address: rcm.montenegro@gmail.com., Vasconcellos MC; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, 69080-900, Brazil. Electronic address: marnevasconcellos@yahoo.com.br.

Publikováno v: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113605. Date of Electronic Publication: 2020 Nov 21.

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Akademický článek

22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2020 Aug; Vol. 66, pp. 104879. Date of Electronic Publication: 2020 Apr 29.

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