Dopaminergic Modulation and Computational ADMET Insights for the Antidepressant-like Effect of N‑(3-(Phenylselanyl)prop-2-yn-1-yl)benzamide.

Autor: Besckow, Evelyn Mianes, Ledebuhr, Kauane Nayara Bahr, Pires, Camila Simões, Rocha, Marcia Juciele da, Kuntz, Natália Emanuele Biolosor, Godoi, Benhur, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Publikováno v: ACS Chemical Neuroscience; 5/1/2024, Vol. 15 Issue 9, p1904-1914, 11p

Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5‑HT2A/C Receptors.

Autor: Garcia, Cleisson Schossler, Besckow, Evelyn Mianes, da Silva Espíndola, Carlos Natã, D'Avila Nunes, Gustavo, Zuge, Narryman Pinto, de Azeredo, Marcos Pizzatto, Rocha, Marcia Juciele da, Carraro Junior, Luiz Roberto, Penteado, Filipe, Gomes, Caroline Signorini, Lenardão, Eder João, Bortolatto, Cristiani Folharini, Brüning, César Augusto

Publikováno v: ACS Chemical Neuroscience; 6/15/2022, Vol. 13 Issue 12, p1746-1755, 10p

Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT 2A/C Receptors.

Autor: Garcia CS; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Besckow EM; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., da Silva Espíndola CN; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., D'Avila Nunes G; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Zuge NP; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., de Azeredo MP; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Rocha MJD; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Carraro Junior LR; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Penteado F; Laboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Gomes CS; Laboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Lenardão EJ; Laboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Bortolatto CF; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil., Brüning CA; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box, 354, Pelotas, 96010-900 RS, Brazil.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2022 Jun 15; Vol. 13 (12), pp. 1746-1755. Date of Electronic Publication: 2022 May 23.