Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Roch Thibert"'
Autor:
Olivier Nicolas, Samuel S. Lee, Maribel Rodriguez-Torres, Curtis Cooper, Eric Lawitz, Jean Bedard, Frank H. Anderson, Peter Ghali, Nathalie Chauret, L. Proulx, Isabel Boivin, Roch Thibert
Publikováno v:
Journal of Hepatology. 51:39-46
Background/Aims VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC 50 values versus genotype 1a/1b replicons. Methods The antiviral activity, pharmacokinetics and tolerability of VCH-759 administered as monot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfea919b6e72f74ec5da8e09d9295678
https://doi.org/10.1016/j.jhep.2009.03.015
https://doi.org/10.1016/j.jhep.2009.03.015
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 47:16-22
A discriminating dissolution method using a USP apparatus 2 dissolution tester was developed for a nitric oxide donating selective COX-2 inhibitor to support phase I and II formulation development, clinical supplies release and stability testing of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2590510925315ca6cd9468665ad5d22e
https://doi.org/10.1016/j.jpba.2007.12.025
https://doi.org/10.1016/j.jpba.2007.12.025
Autor:
Patrick M Gosselin, Sophie-Dorothee Clas, François-Xavier Lacasse, Michel Preda, Jean Norbert Mcmullen, Roch Thibert
Publikováno v:
Pharmaceutical Development and Technology. 8:11-20
Purpose. To compare the physical and physicochemical characteristics of carbamazepine microparticles prepared using two different methods: (1) the rapid expansion of supercritical solutions (RESS) and (2) the spray-drying process. Methods. For both p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30eea28f7091085ce1ddb7277f87bf37
https://doi.org/10.1081/pdt-120017519
https://doi.org/10.1081/pdt-120017519
Publikováno v:
International Journal of Pharmaceutics. 239:149-156
A new chemical entity (NCE) was evaluated in the Clickhaler (Innovata Biomed Ltd.) dry powder inhaler, a reservoir-based multidose delivery system. The standard device metering system was modified to handle higher doses (nominally 20 mm(3) of lactose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf1f8eef0e40d52aef891113a1f8777
https://doi.org/10.1016/s0378-5173(02)00106-0
https://doi.org/10.1016/s0378-5173(02)00106-0
Publikováno v:
Pharmaceutical Research. 19:887-893
Purpose. To characterize the avalanche behavior of different powders and to compare the results of the strange-attractor and novel characterization approaches.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d2d679848f73e606de4205a2a64f9f
https://doi.org/10.1023/a:1016125420577
https://doi.org/10.1023/a:1016125420577
Publikováno v:
Pharmaceutical Research. 16:672-675
Purpose. To evaluate thermomechanical analysis (TMA) as a technique for determining the viscosity of amorphous pharmaceutical materials. This property of amorphous drugs and excipients is related to their average rate of molecular mobility and thus t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c21da5af26709b42a8dd7423cb4570ee
https://doi.org/10.1023/a:1018816406470
https://doi.org/10.1023/a:1018816406470
Autor:
Elizabeth Vadas, Clair F. MacNeish, Jane MacDonald, Roch Thibert, Allan L. Coates, Susan Kelemen, Dale Meisner
Publikováno v:
Chest. 111:1206-1212
The use of inhaled antibiotics in the treatment of cystic fibrosis has become widespread despite controversy in the literature as to the appropriate dosing regimen and its effectiveness. This study compared two tobramycin (T) preparations (one with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09df2580ffca81c1761519533f2fc45b
https://doi.org/10.1378/chest.111.5.1206
https://doi.org/10.1378/chest.111.5.1206
Direct visualization of Superdisintegrant Hydration Using Environmental Scanning Electron Microscopy
Autor:
Bruno C. Hancock, Roch Thibert
Publikováno v:
Journal of Pharmaceutical Sciences. 85:1255-1258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9f394a36362bdfd00571f918e9ec33
https://doi.org/10.1021/js960188d
https://doi.org/10.1021/js960188d
Characterization of the self-association properties of a leukotriene D4 receptor antagonist, MK-0476
Publikováno v:
International Journal of Pharmaceutics. 134:59-70
The development of a liquid dosage form requires a comprehensive understanding of physicochemical properties unique to solutions. The objective of this study was to investigate the behaviour of MK-0476, a potent leukotriene D4 receptor antagonist, us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d82d345aa900e92ed3c76a0675e7e1fa
https://doi.org/10.1016/0378-5173(96)04435-3
https://doi.org/10.1016/0378-5173(96)04435-3
Autor:
Patrick, Gosselin, François-Xavier, Lacasse, Michel, Preda, Roch, Thibert, Sophie-Dorothée, Clas, Jean Norbert, McMullen
Publikováno v:
Pharmaceutical development and technology. 8(1)
To compare the physical and physicochemical characteristics of carbamazepine microparticles prepared using two different methods: (1) the rapid expansion of supercritical solutions (RESS) and (2) the spray-drying process.For both processes, micropart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c0dd3624bb5ef6a6e114523a6a7bf22
https://pubmed.ncbi.nlm.nih.gov/12665193
https://pubmed.ncbi.nlm.nih.gov/12665193