Výsledky vyhledávání - "Roch Philippe"

Akademický článek

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

Autor: Pascal Häfliger, Julien Graff, Matthias Rubin, Amandine Stooss, Matthias S. Dettmer, Karl-Heinz Altmann, Jürg Gertsch, Roch-Philippe Charles

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-15 (2018)

Abstract Background The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino acids across the plasma membrane. While LAT1 is overexpressed in a variety of human neoplasms, its expression and its role in thyroid cancer is currently

Externí odkaz: https://doaj.org/article/8eacdf8b41754b9abae1d4b4b79be208

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Akademický článek

PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models

Autor: Lluís Nisa, Pascal Häfliger, Michaela Poliaková, Roland Giger, Paola Francica, Daniel Matthias Aebersold, Roch-Philippe Charles, Yitzhak Zimmer, Michaela Medová

Publikováno v: Molecular Cancer, Vol 16, Iss 1, Pp 1-14 (2017)

Abstract Background The MET receptor tyrosine kinase represents a promising target in cancer. PIK3CA activating mutations are common in several tumor types and can potentially confer resistance to anti-receptor tyrosine kinase therapy. Methods MET an

Externí odkaz: https://doaj.org/article/b0561ab8e18144edb92013486a22e62a

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