Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rocco Coli"'
Autor:
Theresa L. Johnson, Steven Kazmirski, Simon Low, Cyrille Kuhn, Robert V. Stanton, Yuan-Hua Ding, Gayatri D. Deshmukh, Jessie M. English, Haile Tecle, Glen Rennie, Ping Ye, Hu Liu, Joseph Wu, Alan C. Cheng, Suzanne L. Jacques, Rocco Coli, Frederic Feru
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4885-4891
By targeting an extended region of the conventional 'DFG-out' pocket of p38alpha, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able to design and synthesize a number of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cbf5efbbf3041f28125e01eba59d8c
https://doi.org/10.1016/j.bmcl.2010.06.073
https://doi.org/10.1016/j.bmcl.2010.06.073
Autor:
Rocco Coli, Joseph W. E. Worrall, Wade Diehl, Jonathan P DiNitto, Gayatri D. Deshmukh, Joseph Wu, Yan Zhang, Jessie M. English, Suzanne L. Jacques
Publikováno v:
Journal of Biochemistry. 147:601-609
The activation of receptor tyrosine kinases (RTKs) is tightly regulated through a variety of mechanisms. Kinetic studies show that activation of c-Kit RTK occurs through an inter-molecular autophosphorylation. Phosphopeptide mapping of c-Kit reveals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2606004f880a6da5683d462f41aaa79b
https://doi.org/10.1093/jb/mvq015
https://doi.org/10.1093/jb/mvq015
Autor:
Rocco Coli, B. Ganesh Bhat, Leyu Wang, Meg McLaughlin, Patricia Soulard, Ming-Shang T. Kuo, Jennifer Moore, Brendan Connolly, Can C. Ozbal, Jessica Stevens, William A. LaMarr
Publikováno v:
Analytica Chimica Acta. 627:105-111
Several recent reports suggest that stearoyl-CoA desaturase 1 (SCD1), the rate-limiting enzyme in monounsaturated fatty acid synthesis, plays an important role in regulating lipid homeostasis and lipid oxidation in metabolically active tissues. As se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8dcba29c7b49f14310e9b905c25241
https://doi.org/10.1016/j.aca.2008.04.017
https://doi.org/10.1016/j.aca.2008.04.017
Autor:
Darcy Kohls, Simon Low, Glen Rennie, Yuan-Hua Ding, Cyrille Kuhn, Frederic Feru, Michael Kothe, Rocco Coli
Publikováno v:
Chemical Biology & Drug Design. 70:540-546
Polo-like kinase 1 is an important regulator of cell cycle progression whose over-expression is often associated with oncogenesis. Polo-like kinase 1 hence represents an attractive target for cancer intervention. BI 2536 (Boehringer Ingelheim, Ingelh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f56f22404ef9e96e6c481d195548de
https://doi.org/10.1111/j.1747-0285.2007.00594.x
https://doi.org/10.1111/j.1747-0285.2007.00594.x
Autor:
Simon Low, Rocco Coli, Yuan-Hua Ding, Alan C. Cheng, Alissa L. Sheils, Cyrille Kuhn, Thomas A. Wynn, Theresa L. Johnson, Jim Nonomiya, Suzanne L. Jacques, Darcy Kohls, Cristina Lewis, Michael Kothe, Kimberly A. Verdries, Christine Loh
Publikováno v:
Biochemistry. 46:5960-5971
Polo-like kinase 1 (Plk1) is an attractive target for the development of anticancer agents due to its importance in regulating cell-cycle progression. Overexpression of Plk1 has been detected in a variety of cancers, and expression levels often corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb7b5150b3f78f35926d557efc4acae
https://doi.org/10.1021/bi602474j
https://doi.org/10.1021/bi602474j
Publikováno v:
Gene. 279:81-89
The autosomal recessive disorder familial dysautonomia (FD) has recently been demonstrated to be caused by mutations in the IKBKAP gene, so named because an initial report suggested that it encoded an IkB kinase complex associated protein (IKAP). Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc22a8a0c07d6275558e8c69918bd14c
https://doi.org/10.1016/s0378-1119(01)00737-5
https://doi.org/10.1016/s0378-1119(01)00737-5
Autor:
Berish Y. Rubin, Rocco Coli, Matthew J. Rork, Josef Ekstein, Elizabeth Kichula, Ira W. Daly, Sabrina A. Volpi, Sylvia L. Anderson
Publikováno v:
The American Journal of Human Genetics. 68:753-758
The defective gene DYS, which is responsible for familial dysautonomia (FD) and has been mapped to a 0.5-cM region on chromosome 9q31, has eluded identification. We identified and characterized the RNAs encoded by this region of chromosome 9 in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d9cb00e78fbff312c56ec0f8d36680
https://doi.org/10.1086/318808
https://doi.org/10.1086/318808
Autor:
Steven Kazmirski, Nidhi Jhawar, Jianxing Shao, Emilia Bora, Haile Tecle, Suzanne Jacques-O’Hagan, Yuan-Hua Ding, Deb Moshinsky, Rocco Coli, Jeffrey F. Ohren, Joe Wu, Michael Kothe, Yanhong Li, Julie Penzotti
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(1)
An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09f5110e054b8d468c5c26e328447a7
https://pubmed.ncbi.nlm.nih.gov/19019675
https://pubmed.ncbi.nlm.nih.gov/19019675
Autor:
Michael, Kothe, Darcy, Kohls, Simon, Low, Rocco, Coli, Glen R, Rennie, Frederic, Feru, Cyrille, Kuhn, Yuan-Hua, Ding
Publikováno v:
Chemical biologydrug design. 70(6)
Polo-like kinase 1 is an important regulator of cell cycle progression whose over-expression is often associated with oncogenesis. Polo-like kinase 1 hence represents an attractive target for cancer intervention. BI 2536 (Boehringer Ingelheim, Ingelh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b5ead468ecaa06166846290429bfcb1
https://pubmed.ncbi.nlm.nih.gov/18005335
https://pubmed.ncbi.nlm.nih.gov/18005335