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Akademický článek

Age associations with tacrolimus and mycophenolic acid pharmacokinetics in stable Black and White kidney transplant recipients: Implications for health inequities

Autor: Kathleen M. Tornatore, Kristopher Attwood, Rocco C. Venuto, Brian Murray

Publikováno v: Clinical and Translational Science, Vol 16, Iss 5, Pp 861-871 (2023)

Abstract Tacrolimus (TAC) and mycophenolic acid (MPA) provide maintenance immunosuppression and is dosed empirically in elderly kidney transplant recipients (KTRs) resulting in health inequities. Limited immunosuppressive pharmacokinetics are availab

Externí odkaz: https://doaj.org/article/440f0d06625b4bc99627ccf84b92eb19

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Akademický článek

Comparison of P‐glycoprotein function in peripheral blood mononuclear cells ex vivo in stable Black and White male and female kidney transplant recipients

Autor: Kathleen M. Tornatore, Kris Attwood, Daniel Brazeau, Jason Sprowl, Shirley Chang, Aijaz Gundroo, Hans Minderman, Rocco C. Venuto

Publikováno v: Clinical and Translational Science, Vol 16, Iss 2, Pp 184-192 (2023)

Abstract Kidney allograft survival remains poorer in Black compared to White recipients due to racial differences in calcineurin inhibitor (CNI) pharmacology. P‐glycoprotein (P‐gp), an ABC efflux transporter expressed in peripheral blood mononucl

Externí odkaz: https://doaj.org/article/c87ef4fda0da497e9af057c4ca00fe13

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Akademický článek

The impact of systematic review of status 7 patients on the kidney transplant waitlist

Autor: Ashish Kataria, Madan Gowda, Brian Paul Lamphron, Kabir Jalal, Rocco C. Venuto, Aijaz A. Gundroo

Publikováno v: BMC Nephrology, Vol 20, Iss 1, Pp 1-5 (2019)

Abstract Background Increased morbidity and mortality are well documented in Status 7(inactive list) patients. Delays in transplantation secondary to prolonged periods on inactive status also negatively impacts transplant outcomes. We developed an ef

Externí odkaz: https://doaj.org/article/0690dd5e11df428bbdbfe565bc5969fa

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Akademický článek

Beyond Single Nucleotide Polymorphisms: CYP3A5∗3∗6∗7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients

Autor: Daniel A. Brazeau, Kristopher Attwood, Calvin J. Meaney, Gregory E. Wilding, Joseph D. Consiglio, Shirley S. Chang, Aijaz Gundroo, Rocco C. Venuto, Louise Cooper, Kathleen M. Tornatore

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A5 (CYP3A5) isoenzymes and membrane transport by P-glycoprotein. Interpatient pharmacokinetic variability has been associated with genotypic vari

Externí odkaz: https://doaj.org/article/2e2b5351b6a64c0791d2e891dcce8202

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Akademický článek

A Comprehensive Review of Hypertension in Pregnancy

Autor: Reem Mustafa, Sana Ahmed, Anu Gupta, Rocco C. Venuto

Publikováno v: Journal of Pregnancy, Vol 2012 (2012)

Hypertension is the most common medical disorder encountered during pregnancy. Hypertensive disorders are one of the major causes of pregnancy-related maternal deaths in the United States. We will present a comprehensive update of the literature pert

Externí odkaz: https://doaj.org/article/585023d5948d49de8f3dc93536222e31

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