Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors.

Autor: Rienzo M; From the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125 and., Rocchi AR; the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom., Threatt SD; From the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125 and., Dougherty DA; From the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125 and dadougherty@caltech.edu., Lummis SC; the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 Mar 18; Vol. 291 (12), pp. 6272-80. Date of Electronic Publication: 2015 Dec 14.

Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity.

Autor: Heusser, Stephanie A., Lycksell, Marie, Xueqing Wang, McComas, Sarah E., Howard, Rebecca J., Lindahl, Erik

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 10/16/2018, Vol. 115 Issue 42, p10672-10677, 6p