Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rocío Romero-Granados"'
Autor:
Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2 −/− Atm −/− double-deficient mouse model to
Externí odkaz:
https://doaj.org/article/9f1676662817487ea864a82ec0a5a86d
Autor:
Fernando Gómez-Herreros, Rocío Romero-Granados, Zhihong Zeng, Alejandro Alvarez-Quilón, Cristina Quintero, Limei Ju, Lieve Umans, Liesbeth Vermeire, Danny Huylebroeck, Keith W Caldecott, Felipe Cortés-Ledesma
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003226 (2013)
Anticancer topoisomerase "poisons" exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This characteristic underlies the clinical efficacy of TOP2 poisons, but is also implicat
Externí odkaz:
https://doaj.org/article/b6ee006f88034a179df6e3efdebf08fa
Autor:
Rocío Romero-Granados, Ángela Fontán-Lozano, Francisco Javier Aguilar-Montilla, Ángel Manuel Carrión
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28927 (2011)
Defects in the ubiquitin-proteasome system have been related to aging and the development of neurodegenerative disease, although the effects of deficient proteasome activity during early postnatal development are poorly understood. Accordingly, we ha
Externí odkaz:
https://doaj.org/article/c3b82ea7900e4699a32c8eca9719e014
Autor:
Almudena Serrano-Benitez, Pedro Manuel Martínez-García, Alejandro Álvarez-Quilón, Lourdes García-Quintanilla, Felipe Cortés-Ledesma, José Terrón-Bautista, Irene Delgado-Sainz, Cristina Quintero, Rocío Romero-Granados, Silvia Jimeno-González, Cristina Bernal-Lozano
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Instituto de Salud Carlos III (ISCIII)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffebc15e5b3de553075e378307f9817
http://hdl.handle.net/20.500.12105/9295
http://hdl.handle.net/20.500.12105/9295
Autor:
Julieta Troncoso, Rocío Romero-Granados, Alejandro Múnera, Ángela Fontán-Lozano, José M. Delgado-García, Angel M. Carrión
Publikováno v:
Molecular and Cellular Neuroscience. 39:193-201
Histone deacetylases (HDAC) are enzymes that maintain chromatin in a condensate state, related with absence of transcription. We have studied the role of HDAC on learning and memory processes. Both eyeblink classical conditioning (EBCC) and object re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f47d59602ceb20567e689a9329f434e
https://doi.org/10.1016/j.mcn.2008.06.009
https://doi.org/10.1016/j.mcn.2008.06.009
Autor:
Sean Ennis, Elijah Chaila, Stuart L. Rulten, Rocío Romero-Granados, Felipe Cortés-Ledesma, Bert B.A. de Vries, Norman Delanty, Judith Conroy, Janneke H M Schuurs-Hoeijmakers, Fernando Gómez-Herreros, Gianpiero L. Cavalleri, Timothy J. Counihan, Marie T. Greally, Sherif F. El-Khamisy, Mark McCormack, Arjan P.M. de Brouwer, Keith W. Caldecott
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Genetics, 46, 516-21
Nature Genetics, 46, 5, pp. 516-21
instname
Nature Genetics, 46, 516-21
Nature Genetics, 46, 5, pp. 516-21
Gómez-Herreros, Fernando et al.
Topoisomerase II (TOP2) removes torsional stress from DNA and facilitates gene transcription by introducing transient DNA double-strand breaks (DSBs). Such DSBs are normally rejoined by TOP2 but on occasion can b
Topoisomerase II (TOP2) removes torsional stress from DNA and facilitates gene transcription by introducing transient DNA double-strand breaks (DSBs). Such DSBs are normally rejoined by TOP2 but on occasion can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e3019c94160890f776b71120224f14
http://hdl.handle.net/10261/123519
http://hdl.handle.net/10261/123519
Publikováno v:
Hippocampus. 20(5)
Neuropsychological analyses of amnesic patients, as well as lesion experiments, indicate that the temporal lobe is essential for the encoding, storage, and expression of object recognition memory (ORM). However, temporal lobe structures directly invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f451b33c672758d8571c62ddc18a4dd
https://pubmed.ncbi.nlm.nih.gov/19603520
https://pubmed.ncbi.nlm.nih.gov/19603520
Autor:
Rocío Romero-Granados, Danny Huylebroeck, Alejandro Álvarez-Quilón, Zhihong Zeng, Cristina Quintero, Fernando Gómez-Herreros, Keith W. Caldecott, Lieve Umans, Felipe Cortés-Ledesma, Limei Ju, Liesbeth Vermeire
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
PLoS Genetics, Vol 9, Iss 3, p e1003226 (2013)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Genetics, Vol 9, Iss 3, p e1003226 (2013)
Digital.CSIC. Repositorio Institucional del CSIC
Gómez-Herreros, Fernando et al.
Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This characteristic underlies the clinical efficacy
Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This characteristic underlies the clinical efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895cea114bcc629c013279a95b688d4c
https://doi.org/10.1371/journal.pgen.1003226
https://doi.org/10.1371/journal.pgen.1003226
Autor:
Rocío Romero-Granados, Ángela Fontán-Lozano, José M. Delgado-García, Josef M. Penninger, Irene Suárez-Pereira, Yaiza del-Pozo-Martín, Angel M. Carrión
Publikováno v:
Current Biology. (1):54-60
SummaryMemory deficits in aging affect millions of people and are often disturbing to those concerned. Dissection of the molecular control of learning and memory is paramount to understand and possibly enhance cognitive functions. Old-age memory loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f0cb7608564e258c46b4bf5aa8b735